33CHNB - skuPrimaryImage

Core 3 Health

Skip to product information
33CHNB - skuPrimaryImage
  • 33CHNB - skuPrimaryImage
  • 33CHNB - skuPrimaryImage
  • 33chnb_Alt678 - media
  • 44CHB_Alt2 - media
  • 44CHB_Alt1 - media
  • 13007_Alt_GC8_800 - media
  • 13007_Alt_GC9_800 - media
  • 12989_altR - media
  • 12989_altL - media
  • 14506_Rev0226_L - media
  • 14506_Rev0226_R - media
  • 44CHB - skuPrimaryImage
  • 44chb_Alt1linker - media
  • 44CHB_Alt2 - media
  • 44CHB_Alt1 - media
  • 13010_Leftt - media
  • 13010_Rightt - media
  • 12989_altR - media
  • 12989_altL - media
  • 14506_Rev0226_L - media
  • 14506_Rev0226_R - media
  • 33CHNB - skuPrimaryImage
  • 33CHNB - skuPrimaryImage
  • 33chnb_Alt678 - media
  • 44CHB_Alt2 - media
  • 44CHB_Alt1 - media
  • 13007_Alt_GC8_800 - media
  • 13007_Alt_GC9_800 - media
  • 12989_altR - media
  • 12989_altL - media
  • 14506_Rev0226_L - media
  • 14506_Rev0226_R - media
  • 44CHB - skuPrimaryImage
  • 44chb_Alt1linker - media
  • 44CHB_Alt2 - media
  • 44CHB_Alt1 - media
  • 13010_Leftt - media
  • 13010_Rightt - media
  • 12989_altR - media
  • 12989_altL - media
  • 14506_Rev0226_L - media
  • 14506_Rev0226_R - media
Core 3 Health

Core 3 Health

Isotonix®
$119.95 – $149.95 $154.85 – $194.85 23% off
  • Reset, Rebuild and Restore
  • Three Products - Three Simple Steps
  • OPC-3® for Oxygen Delivery
  • Prime NAD+ for Cell Renewal
  • Magnesium for Quality Sleep
Product Option:
Code  33CHNB
Product Features

Maximum Effect. Amazing Results. A New You with Core 3 Health.

Discover the revitalizing synergy of these three powerhouse products, used in three simple steps! 

Isotonix OPC-3®. The world’s most powerful antioxidant, for oxygen delivery, glowing skin and a surge of vitality. 

Prime Anti-Aging Nutraceuticals® NAD+. Renews cells and DNA integrity, mental sharpness and feeling youthful. 

Isotonix® Magnesium. Stress-busting, sleep-enhancing, heart-strengthening and energy-activating.
Ingredients

Isotonix OPC-3 Active Ingredients: Grape seed extract, Pycnogenol® (pine park extract), red wine extract, bilberry extract, citrus bioflavonoid complex 

Other ingredients: Fructose, glucose, citric acid, potassium bicarbonate, maltodextrin, silica, calcium sulfate, food starch (modified), apple pectin, stearic acid. 

Prime NAD+ Active Ingredients: Crystalline nicotinamide riboside chloride, pterostilbene 

Other Ingredients: Vegetarian capsule (hypromellose), microcroystalline cellulose, vegetable magnesium stearate, silicon dioxide

Isotonix Magnesium Active Ingredients: Magnesium (citrate and glycinate) 

Other Ingredients: Fructose, malic acid, citric acid, orange juice powder, potassium bicarbonate, orange flavor, passionfruit flavor, silicon dioxide, rebaudioside A (stevia leaf), luo han guo fruit extract, stearic acid

  • Free shipping on orders over $125.00
Code  33CHNB

Triple Threat Daily Regimen

Isotonix OPC-3

95% intestinal nutrient delivery for max absorption

Isotonix Magnesium

Support 300+ enzyme systems

Prime NAD+

The secret to healthy aging

Includes our top seller, Isotonix OPC-3

The super antioxidant in OPC-3, pine bark extract (Pycnogenol®)
Isotonix OPC-3 contains the only isotonic form of Pycnogenol®, is a natural plant extract from the bark of the French maritime pine tree and the most clinically researched and powerful bioflavonoids in the world.

image of pine bark

Key ingredients

image of pine bark

Isotonix OPC-3®: Pycnogenol®‡, Pine Bark Extract*

Supports the normal dilation of blood vessels

Provides complete antioxidant protection

Combats free radicals

Supports a healthy complexion

Promotes healthy sperm quality
image of blueberries against a blue background

Isotonix OPC-3®: Bilberry Extract*

Powerful antioxidant

Supports healthy vision

Maintains healthy circulation
Image of magnesium against a blue background

Isotonix® Magnesium: Magnesium (Citrate & Glycinate)*

Helps the body maintain a healthy level of magnesium, combatting magnesium deficiency

Promotes muscle health and comfort

Supports a healthy sleep quality

Promotes bone health
image of magnified cells

Prime Anti-Aging Nutraceuticals® NAD+: Nicotinamide Riboside (crystalline nicotinamide riboside chloride)*

Supports healthy NAD production 

Combat the cellular aging process 

Promotes normal activity of the SIRT-1 gene 

Supports cellular health and metabolism 

Directions for Use

image of one capful Isotonix OPC-3 and one capful Isotonix Magnesium

Step 1 (Morning): Take Isotonix OPC-3 and the first capful of Isotonix Magnesium when you wake up.

image of canister of Prime NAD+

Step 2 (Midday): Take Prime NAD+ before your midday meal.

image of one capful of Isotonix Magnesium with the product bottle

Step 3 (Evening): Take the second capful of Isotonix Magnesium before you go to bed.

Revitalize Your Body With Core 3 Health

Restore, rebuild and reset with Core 3 Health: three powerful products in three simple steps. Our hottest health superstars have been carefully selected for one triple-threat system for maximum effect and truly amazing results.

Frequently asked Questions

When is the best time to take these products?
Take Isotonix OPC-3 and Isotonix Magnesium in the morning. Take Prime NAD+ 4–5 hours later, then another serving of Isotonix Magnesium before bed. This 1-2-3 system supports metabolic health and sleep.
Why is there sugar in Isotonix products?
The sugars make the solution isotonic, enhancing nutrient absorption into the bloodstream and optimizing the delivery of nutrients to target cells.
Does Core 3 Health work for second or third shift workers?
Yes, follow the 1-2-3 schedule based on your sleep cycle. Take Isotonix OPC-3 and Magnesium when you wake up, Prime NAD+ 4-5 hours later and Magnesium before bed.
What makes Isotonix OPC-3 unique?
Isotonix OPC-3 is delivered in an isotonic form for quick absorption. It combines powerful antioxidants like Pycnogenol®, bilberry, and grape seed extracts, supporting cardiovascular health, joint flexibility, and free radical protection.
What makes Isotonix Magnesium unique?
Isotonix Magnesium provides 400 mg of highly bioavailable magnesium forms (glycinate and citrate), supporting brain function, muscle health, and stress management.
What makes Prime NAD+ unique?
Prime NAD+ supports NAD+ levels with 250 mg of nicotinamide riboside (NR) and 50 mg of pterostilbene, supporting cellular regeneration, mitochondrial health, and DNA integrity.

Research Scope on Core 3 Health

Reference List

Isotonix OPC-3

  • Cardona F, Andrés-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuño MI. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem. 2013 Aug;24(8):1415-22. doi: 10.1016/j.jnutbio.2013.05.001. PMID: 23849454.
  • Dueñas M, Muñoz-González I, Cueva C, Jiménez-Girón A, Sánchez-Patán F, Santos-Buelga C, Moreno-Arribas MV, Bartolomé B. A survey of modulation of gut microbiota by dietary polyphenols. Biomed Res Int. 2015;2015:850902. doi: 10.1155/2015/850902. Epub 2015 Feb 22. PMID: 25793210; PMCID: PMC4352430
  • Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
  • Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
  • Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
  • Kumar Singh A, Cabral C, Kumar R, Ganguly R, Kumar Rana H, Gupta A, Rosaria Lauro M, Carbone C, Reis F, Pandey AK. Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency. Nutrients. 2019 Sep 13;11(9):2216. doi: 10.3390/nu11092216. PMID: 31540270; PMCID: PMC6770155.
  • Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
  • Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004.
  • Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
  • Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
  • Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
  • Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
  • Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
  • Williamson G, Sheedy K. Effects of Polyphenols on Insulin Resistance. Nutrients. 2020 Oct 14;12(10):3135. doi: 10.3390/nu12103135. PMID: 33066504; PMCID: PMC7602234.

Prime Anti-Aging Nutraceuticals NAD+

  • Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
  • Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
  • Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in ""Normal"" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
  • Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy
  • ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
  • Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
  • Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74. 
  • Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018). 
  • de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021. 
  • Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17. 
  • Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916. 
  • Hanhineva K, Törrönen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykkänen H, Poutanen K. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci. 2010 Mar 31;11(4):1365-402. doi: 10.3390/ijms11041365. PMID: 20480025; PMCID: PMC2871121.
  • Kim Y, Keogh JB, Clifton PM. Polyphenols and Glycemic Control. Nutrients. 2016 Jan 5;8(1):17. doi: 10.3390/nu8010017. PMID: 26742071; PMCID: PMC4728631.
  • Maiese K. Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer. Curr Neurovasc Res. 2017;14(3):299-304. doi: 10.2174/1567202614666170718092010. PMID: 28721811; PMCID: PMC5600856.
  • Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018. 
  • Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357. 
  • Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485. 
  • Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316. 
  • Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87. 
  • Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78. 

Isotonix Magnesium

  • Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
  • Wester PO. Magnesium. Am J Clin Nutr. 45:1305-12, 1987.
  • Saris NE, Mervaala E, et al. Magnesium: an update on physiological, clinical, and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
  • Vormann J. Magnesium: nutrition and metabolism. Molecular Aspects of Medicine. 24:27-37, 2003.
  • Rude KR. Magnesium metabolism and deficiency. Endocrinol Metab Clin North Am. 22:377-95, 1993.
  • Kobrin SM and Goldfarb S. Magnesium Deficiency. Semin Nephrol. 10:525-35, 1990.
  • Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 69(4):727-36, 1999.
  • Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
  • New SA et al. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr. 65:1831-9, 1997.
  • Gruber H et al. Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton. BMC Musculoskelet Disord. 4(1):7, 2003.
  • Ryder K et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc. 53(11):1875-1880, 2005.
  • Rude R et al. Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem. 15(12):710-716, 2004.
  • Bilbey, D.L. J., et al. Muscle cramps and magnesium deficiency: case reports. Can Fam Physician. 42:1348-51, 1996.
  • Dahle, L. O., et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 173(1):175-180, 1995.
  • Saris, N.-E. L., et al. Magnesium: an update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
  • Serizawa N, Nishimuta M, Kodama N, Shimada M, Yoshitake Y, Hongu N, Ota M, Yano T. Salt Restriction Affects the Excretions of Minerals (Na, K, Ca, Mg, P and Zn) in the Second Voided Fasting Early Morning Urine. J Nutr Sci Vitaminol (Tokyo). 2019;65(2):142-147. doi: 10.3177/jnsv.65.142. PMID: 31061282.
  • Yamanaka R, Tabata S, Shindo Y, Hotta K, Suzuki K, Soga T, Oka K. Mitochondrial Mg(2+) homeostasis decides cellular energy metabolism and vulnerability to stress. Sci Rep. 2016 Jul 26;6:30027. doi: 10.1038/srep30027. PMID: 27458051; PMCID: PMC4960558.
  • Dmitrašinović G, Pešić V, Stanić D, Plećaš-Solarović B, Dajak M, Ignjatović S. ACTH, Cortisol and IL-6 Levels in Athletes following Magnesium Supplementation. J Med Biochem. 2016 Nov 2;35(4):375-384. doi: 10.1515/jomb-2016-0021. PMID: 28670189; PMCID: PMC5471632
  • Yu-Yahiro, J. A. Electrolytes and their relationship to normal and abnormal muscle function. Orthop Nurs. 13(5):38-40, 1994.
  • Brilla, L. R., et al. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr. 11(3):326-329, 1992.
  • Sato-Mito N et al. The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women. Sleep Med. 12(3):289-94, 2011.
  • Saris, N.-E. L., et al. Magnesium: an update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
  • Huskisson E et al. The influence of micronutrients on cognitive function and performance. J Int Med Res. 35(1):1-19, 2007. Review.
  • Inna Slutsky et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 65(2):165-77, 2010.
  • Arab A, Rafie N, Amani R, Shirani F. The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature. Biol Trace Elem Res. 2023 Jan;201(1):121-128. doi: 10.1007/s12011-022-03162-1. Epub 2022 Feb 19. PMID: 35184264.

100

The number of active compounds found in Red Wine Extract

30+

trillion cells in the body are fueled by the NAD molecule

300

Magnesium supports more than 300 enzyme systems

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

‡As Pycnogenol®. Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.

Customer Reviews

Write Your Review

☆ ☆ ☆ ☆ ☆

Show a Picture or Image:

(You may upload up to 3 images - png or jpeg)

Add Video:

(You may upload up to 1 video; up to 30 seconds or 50 MB in size)

You may also like