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Prime™ NMN

Single canister (30 servings)
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Prime™ NMN

Prime™ NMN

Prime™
$59.95
  • The Most Direct Pathway to Anti-Aging NAD+
  • Biohack Your Physiology With Just Two Capsules
  • Engineered to Support 30 Trillion Cells
  • Look and Feel Younger at Any Stage of Life

Single canister (30 servings)

Code  14510
+ $1.20 / 2.0% Cashback
Product Features

Prime Your Cells for Tomorrow

Next-gen vitality begins at the cellular level. Prime™ NMN is designed to biohack cellular health by delivering NMN—the most direct precursor to NAD+ production, supporting the body’s primary pathway for cellular energy and health.

This advanced triple-action formula combines NMN, fisetin, and spermidine to support cellular performance and metabolism — helping fuel energy, physical strength, mental focus, and sustained youth at any age.
Ingredients

Active Ingredients: Nicotinamide Mononucleotide (NMN), Fisetin, Spermidine (as Yuth™†).

Inactive Ingredients: Microcrystalline cellulose, magnesium stearate, silicon dioxide, vegetable capsule.

  • Free shipping on orders over $125.00
Code  14510

Powered by Ingredients with Clinically Relevant Science

NMN

Supports improvements in physical vitality in adults. Studies show that adults supplementing with NMN experienced improvements in walking speed, grip performance and sleep quality.

Spermidine (Yuth™)

Levels and the body’s ability to absorb it decline with age. Evidence suggests that healthy levels of this compound are associated with healthy aging and longevity.

Fisetin

has strong antioxidant activity and supports cellular health pathways related to healthy aging.

NMN — The Direct NAD+ Precursor

Engineered for fast uptake and powerful cellular support.
NMN is one of the closest precursors to NAD+, helping the body maintain healthy NAD+ levels as they naturally decline with age. Research shows orally administered NMN is absorbed rapidly and supports NAD+ production in key tissues. By helping maintain NAD+ availability, NMN supports mitochondrial function, energy production, metabolic function and cellular health against everyday stressors.

Image of cells
image of a group of people doing a yoga plank

The Prime™ Approach to Cellular Support

NMN, fisetin and spermidine each contribute to overall cellular health. NMN supports NAD+ metabolism and cellular energy, fisetin helps defend against oxidative stress and spermidine helps maintain cellular balance. Together, they provide broad foundational support for healthy aging.

Key ingredients

Elderly person working out

Supports Muscle Performance with Age*

Supports energy production in muscle tissue.
image of a brain

Supports Cognitive Function*

NMN and fisetin support cellular pathways involved in healthy brain function.  

Antioxidant support from fisetin supports overall cellular health.
image of person with hands over stomach

Helps Maintain Metabolic Health*

Spermidine intake is associated with healthy metabolic markers.  

Supports metabolic health and helps maintain normal glucose levels.
image of a cell

Supports Antioxidant Activity*

Fisetin is a well-studied antioxidant that helps neutralize free radicals.  

Spermidine and NMN support the body’s antioxidant defense systems.
image of a mitochondira

Supports Cellular Energy*

NMN supports NAD+ metabolism, a cofactor essential for cellular ATP production.  

Research shows NMN promotes NAD+ metabolites. 

Fisetin helps support healthy mitochondrial function.  

Spermidine supports overall cellular balance for efficient energy use.
a healthy older person sitting on a couch

Supports Healthy Aging*

NMN helps maintain NAD+ levels that decline with age.  

Spermidine intake may correlate with healthy aging.  

Fisetin promotes cellular antioxidant support.

The Future of Cellular Energy Starts Here

Keeping your cellular NAD+ levels at their peak is essential for vibrant energy, optimal mitochondrial functioning and graceful aging. Prime™ NMN harnesses cutting-edge science with a powerful trio of ingredients working in harmony to supercharge cellular health at the foundation while supporting your body’s antioxidant defenses. Choose Prime™ NMN — your partner in biohacking vitality for cellular resilience and a healthier tomorrow.

Frequently Asked Questions

How do Prime™ NMN and Prime™ NAD+ work differently?
NMN and NR are different NAD+ precursors that support the body’s NAD+ pool through distinct metabolic routes. The body regulates NAD+ production, so using both may offer a broader support profile, though more isn’t always better.
Will I benefit from taking both together?
Both can support NAD+ levels, and each influences the pathway differently. Taking both may provide broader longevity supporting benefits, and current research does not indicate safety concerns at typical dosages.
If I take Prime NAD+, should I switch?
Both Prime NAD+ and Prime NMN support NAD+ production; the choice is based on preference for the specific precursor and additional support ingredients.
What products pair well with Prime™ NMN?
Isotonix OPC-3® supports oxidative balance and Isotonix® Activated B Complex helps provide B vitamin cofactors involved in NAD+ metabolism.
What daily amount of NMN supports healthy aging?
Many clinical studies use around 500 mg of NMN. Consistency appears important because NAD+ levels decline after stopping supplementation.
Does this product support men and women equally?
Research suggests NMN and NR support both men and women. Benefits relate more to age than gender.
What are NAD+ precursors?
They are compounds that help maintain NAD+ production pathways, including NMN, NR, NAM, NA and tryptophan.
When is the best time to take it?
Most users take it in the morning with food, aligning with natural energy rhythms.
What else depletes NAD+ levels?
Lifestyle factors such as poor sleep, low activity, smoking, and alcohol can contribute to lower NAD+ levels.

Research Scope

Reference List

  • ProHealth Longevity. Sirtuins and your health: ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
  • Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
  • Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
  • Manager. (2024, October 29). The best NAD+ precursor, NMN, NR, NA or Trp? - Uthever®︎. Uthever®︎. https://www.uthever.com/the-best-nad-precursor-nmn-nr-na-or-trp/
  • Gender difference: NAD+ loss significantly higher in middle-aged men than women – BYHEALTH study. (2022, June 13). NutraIngredients.com. https://www.nutraingredients.com/Article/2022/06/13/nad-loss-significantly-higher-in-middle-aged-men-than-women-byhealth-study/
  • Download Center - Uthever®︎: NMN White Paper. (n.d.). Uthever®︎. https://www.uthever.com/about-us/download-center/
  • Nguyen, A. (2025, September 23). Why you can’t take NAD+ directly—and the best precursor to boost NAD+ effectively. AboutNAD. https://www.aboutnad.com/blogs/blog/why-you-can-t-take-nad-directly-and-the-best-precursor-to-boost-nad-effectively
  • Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., Migaud, M. E., & Imai, S. I. (2019). Slc12a8 is a nicotinamide mononucleotide transporter. Nature metabolism, 1(1), 47–57. https://doi.org/10.1038/s42255-018-0009-4
  • Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., ... & Itoh, H. (2020). Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocrine journal, 67(2), 153-160.
  • Hsu, C. P., Yamamoto, T., Oka, S., & Sadoshima, J. (2014). The function of nicotinamide phosphoribosyltransferase in the heart. DNA repair, 23, 64–68. https://doi.org/10.1016/j.dnarep.2014.08.005
  • com. (n.d.). https://www.nad.com/news/nmn-increases-nad-enhances-physical-performance
  • Elysium Health. (2022, November 18). Benefits of NMN supplementation: From day 1 to 6 months. https://www.elysiumhealth.com/blogs/aging101/benefits-of-nmn
  • Kelsey. (2023, March 20). What is YüthTM from Compound Solutions? - Compound Solutions. Compound Solutions. https://compoundsolutions.com/what-is-yuth-from-compound-solutions/
  • Currais, A., Farrokhi, C., Dargusch, R., Armando, A., Quehenberger, O., Schubert, D., & Maher, P. (2017). Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(3), 299.
  • Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: A Dietary Antioxidant for Health Promotion. ANTIOXIDANTS & REDOX SIGNALING, 19(2).
  • Klimova, N., Long, A., & Kristian, T. (2019). Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3 dependent mechanism in male mice. Journal of neuroscience research, 97(8), 975.
  • Shade, C. (2020). The science behind NMN–A stable, reliable NAD+ activator and anti-aging molecule. Integrative Medicine: A Clinician's Journal, 19(1), 12.
  • Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell metabolism, 27(3), 513-528.
  • (2024, September 27). Synergy of NMN, resveratrol and spemidine. How they all work together for anti-aging? - Rescence. https://rescence.com/synergy-of-nmn-resveratrol-spermidine/

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

†As Yuth. Yuth™ is a trademark of Compound Solutions.

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