Primary Benefits of TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula:

• Acts as an adaptogen, allowing a body to appropriately respond to stress placed on it
• Impacts hormones affected by stress
• Helps body adapt to stress
• May help reduce occasional fatigue associated with stress
• May help to minimize certain stress-related issues (weight gain, difficulty sleeping, etc.)
• Helps to reduce stress placed on the adrenals to perform, thereby helping to decrease the possibility of adrenal fatigue
• May help to support normal hypothalamic-pituitary adrenal (HPA) functions
• May help support normal thyroid function
• Helps to promote healthy levels of cortisol
• Helps maintain healthy levels of both serotonin and dopamine
• Helps enhance and stabilize mood
• Helps to stabilize emotional responses to stress
• May help to maintain normal thyroid function
• Promotes relaxation without drowsiness
• Supports improved mental clarity

Key Ingredients Found in TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula:

Sensoril® Trim/Ashwagandha root extract: 450 mg

Ashwagandha has antioxidant and sedative properties. It has been proven to act as an adaptogen by helping to inhibit occasional fatigue, boost energy, promote emotional well-being and counteract the negative effects of stress. Preliminary evidence suggests ashwagandha helps to regulate stress-induced levels of dopamine receptors in the corpus striatum of the brain. It also appears to promote normal levels of plasma corticosterone, blood urea nitrogen and blood lactic acid. Acting as an adaptogen, ashwagandha reduces stress placed on adrenals to perform, thereby helping to decrease the possibility of adrenal fatigue. Though the exact mechanisms by which ashwagandha works are unknown, one hypothesis is that it functions by way of GABA-mimetic activity which acts independently of GABA receptors. In addition to its adaptogenic properties, ashwagandha may promote normal regulation of thyroid function. It has been shown to promote healthy serum levels of the thyroid hormones triodothyronine (T₃) and thyroxine (T₄), both of which are important in promoting normal metabolism.  

Holy Basil: 375 mg

Holy basil has adaptogenic and calming activities. Research shows holy basil may help to promote normal plasma corticosterone levels and hepatic and renal functions, help maintain normal blood glucose levels and inhibit several other stress-related issues. Though the exact mechanism of action is not known, it is believed that much of holy basil's effect on stress comes from its high content of eugenol, caryophyllene and triterpenoic acids, such as ursolic and oleanolic acids. Studies have shown eugenol to be effective at promoting normal cyclooxygenase 2 (COX 2), an enzyme involved with the inflammatory response. 

L-Theanine: 200 mg

L-Theanine is an amino acid found in green tea and some mushrooms. Preliminary evidence suggests that l-theanine might induce subjective feelings of tranquility in healthy people. It is believed that l-theanine may work by promoting normal levels of the neurotransmitters GABA (Gamma Amino Butyric Acid) and dopamine in the central nervous system. GABA is the primary inhibitory neurotransmitter which promotes calimg effects at the cellular level. Dopamine aids in the regulation of many functions within the brain in regards to behavior, cognition, sleep, mood, attention and memory, and is often associated with the ‘reward’ or ‘pleasure’ center of the brain. 

Passion Flower Extract: 200 mg

Passion flower has sedative and relaxation effects. Some studies have pointed to the flavonoids in passion flower such as apigenin, vitexin and isovitexin as the primary constituents responsible for its effects. Research suggests apigenin can bind to central benzodiazepine receptors in the brain, possibly causing relaxation and helping regulate mood without impairing memory or motor skills.

 
Bacopin® (Bacopa monniera Leaf): 150 mg

Bacopa monniera, also referred to as brahmi, has a long history of use in Ayurvedic health for memory enhancement, support of learning and mood enhancement. Constituents of bacopa, specifically bacosides A and B, have been shown to support learning ability, cognitive performance and improve mood. Bacopa also contains the flavonoids apigenin and luteolin. Research suggests apigenin can bind to central benzodiazepine receptors in the brain, possibly causing relaxation and helping regulate mood without impairing memory or motor skills. 

Rhodiola rosea Root Extract: 150 mg

Rhodiola, or roseroot, acts as an antioxidant and adaptogen, promotes relaxation and mental clarity, and helps to improve mood. Research suggests that salidroside, one of over 30 compounds found in rhodiola, is responsible for its stimulating and adaptogenic effects. Within the brain, rhodiola appears to influence the level, activity and transport of monoamine neurotransmitters, such as dopamine, epinephrine and norepinephrine, and serotonin. Rhodiola has been proposed to promote healthy neurotransmitter levels.

Iodine: 150 mcg

The most important function of iodine is promoting normal thyroid function and contributing to the body’s normal production of thyroid hormones. Iodine is absolutely crucial in maintaining optimal thyroid health.

Eleuthero Root (Eleutherococcus senticosus) Extract: 100 mg
Research has shown that eleuthero root, also known as 'Siberian ginseng,' has antioxidant, adaptogenic, sedative, as well as many other effects. As an adaptogen, it helps promote the normal regulation of the endocrine system's response to stressors. The active compounds in eleuthero root, eleutherosides, are believed to stimulate the pituitary-adrenocortical system allowing for more efficient regulation of the stress response and healthy levels of cortisol. Other research suggests that it may help to support feelings of well-being, reduce occasional fatigue and improve memory and cognitive performance.

Scientific Support for TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula:                                           

• Archana, R., et al.  Antistressor effect of Withania somnifera.  Journal of Ethnopharmacology.  64(1): 91-93, 1999.
• Bhattacharya, S., et al.  Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress.  Pharmacology  Biochemistry and Behavior.  75(3): 547-555, 2003.
• Davydov, M. and Krikorian, A. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. Journal of Ethnopharmacology. 72: 345-393, 2000.
• Dhuley, J.  Effect of ashwagandha on lipid peroxidation in stress-induced animals.  Journal of Ethnopharmacology.  60(2): 173-178, 1998.
• Dhuley, J. Adaptogenic and cardioprotective action of ashwagandha in rats and frogs. Journal of Ethnopharmacology. 70(1): 57-63, 2000.
• Head, K. and Kelly, G. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep.  Alternative Medicine Review.  14(2): 114-140, 2009.
• Gaffney, B., et al.  Panax ginseng and Eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors.  Medical Hypotheses.  56(5): 567-572, 2001.
• Kelly, G. Nutritional and botanical interventions to assist with the adaptation to stress. Alt Med Review 4: 249-265, 1999.
• Muruganandam A., et al. Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Indian Journal of Experimental Biology. 40:1151-1160, 2002.
• Rai, D. Adaptogenic effect of Bacopa monniera (Brahmi). Pharmacology  Biochemistry and Behavior.  75(4): 823-830, 2003.
• Singh, S. and Majumdar, D. Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). Journal of Ethnopharmacology. 65: 13-19, 1999.
• Spasov, A. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 7(2): 85-89, 2000.
• Muruganandam A., et al. Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Indian Journal of Experimental Biology. 40: 1151-1160, 2002.
• Head, K. and Kelly, G. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep.  Alternative Medicine Review.  14(2): 114-140, 2009.
• Ito, K., et al.  Effects of L-theanine on the release of alpha brain waves in human volunteers.  Nippon Nogeikagaku Kaishi. 72: 153-157, 1998.
• L-theanine Monograph. Alternative Medicine Review. 10(2): 136-138, 2005.
• Yokogoshi, H.  Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochemical Research. 23(5): 667-673, 1998.
• Akhondzadeh, S., et al.  Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam.  Journal of Clinical Pharmacy and Therapeutics.  26(5): 363-367, 2001.
• Archana, R., et al.  Antistressor effect of Withania somnifera.  Journal of Ethnopharmacology.  64(1): 91-93, 1999.
• Bhattacharya, S., et al.  Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study.  Phytomedicine.  7(6): 463-469, 2000.
• Dhawan, K., et al.  Anti-anxiety studies on extracts of Passiflora incarnata Linneaus.  Journal of Ethnopharmacology..  78(2-3): 165-170, 2001.
• Dhuley, J. Adaptogenic and cardioprotective action of ashwagandha in rats and frogs. Journal of Ethnopharmacology. 70(1): 57-63, 2000.
• Head, K. and Kelly, G. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep.  Alternative Medicine Review.  14(2): 114-140, 2009.
• Kobayashi, K., et al.  Effects of L-theanine on the release of alpha-brain waves in human volunteers.  Journal of the Agricultural Chemical Society of Japan.  72(2): 153-157, 1998.
• Muruganandam A., et al. Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Indian Journal of Experimental Biology. 40: 1151-1160, 2002.
• Sairam K., et al. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine. 9(3): 207-211, 2002.
• Dufresne, C. and Farnworth, E. A review of latest research findings on the health promotion properties of tea. The Journal of Nutritional Biochemistry. 12(7): 404-421, 2001.
• Ito, K., et al.  Effects of L-theanine on the release of alpha brain waves in human volunteers.  Nippon Nogeikagaku Kaishi.  72: 153-157, 1998.
• Lu, K., et al. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Human Psychopharmacology. 19(7): 457-465, 2004.
• Bacopa monniera. Monograph. Alternative Medicine Review. 9: 79-85, 2004. 
• L-theanine Monograph. Alternative Medicine Review. 10(2): 136-138, 2005.
• Spasov, A. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 7(2): 85-89, 2000.
• Gohil KJ, Patel JA. A review on Bacopa monniera: Current research and future prospects. International Journal of Green Pharmacy. 4(1):1-9, 2010.
• Kar, A., et al. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in mice.  Journal of Ethnopharmacology. 81(2): 281-285, 2002.
• Khanum, F., et al.  Rhodiola rosea: a versatile adaptogen.  Comprehensive Reviews in Food Science and Food Safety.  4:55-62, 2005.
• Panda, S. and Kar, A.  Changes in thyroid hormone concentration after administration of ashwagandha root extract to adult male mice. Journal of Pharmacy and Pharmacology.  50(9): 1065-1068, 1998.
• Panda, S. and Kar, A.  Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Journal of Ethnopharmacology.  67(2): 233-239, 1999.
• Panda, S. and Kar, A. combined effects of ashwagandha, guggulu and bauhinia extracts in the regulation of thyroid function and on lipid peroxidation in mice.  Journal of Pharmacy and Pharmacology.  6(3): 141-143, 2000.

What Makes TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula Unique?

Your job demands a lot of your time. Your family demands just as much, if not more. Trips to the mailbox are greeted by bills. Every day, life is taking its toll on you. Even in seemingly good times, stress is something we cannot escape; not only does it have a harmful affect on us mentally, but it can also wreck havoc on us physically – including on our waistlines.*

When we are faced with stress, our bodies go into "fight or flight" response and certain hormones are released by the adrenal gland, hormones that would give the body a burst of energy and strength. This response used to be beneficial to our ancestors, allowing their bodies to physically fight or run away when faced with danger. But in today’s society, this response acts much differently, taking place as a result of stressful days at the office or traffic jam on your way home. The response is supposed to return to normal once the perceived threat is gone, but if the body is unable to return to normalcy due to increased stress levels, it could have a negative effect upon the body with symptoms including adrenal fatigue, suppressed thyroid function, an imbalance in blood sugar levels, and increased abdominal (adipose) fat.*

One of the hormones released during this “fight or flight” response is cortisol, which increases blood sugar, suppresses the immune system, and aids in fat, protein and carbohydrate metabolism. Under normal circumstances, cortisol helps restore homeostasis after stress. The problem is that constant stress leads to a constant state of cortisol production, which stimulates glucose production. This excess glucose is typically converted into fat, ending up as stored fat. High cortisol levels can also lead to binge eating. Not only do high cortisol levels make you want to keep on snacking, but excess cortisol also contributes to storing more belly fat, which is known to be a bit harder to lose.* 

Cortisol levels also have a direct relationship with the thyroid, and they act synergistically with one another. Cortisol assists the thyroid hormone in working more efficiently, and the correct amount of cortisol – not too high or too low – supports normal thyroid function. When cortisol gets too high, triggered by the adrenal glands response to elevated stress, it causes a delayed response to the thyroid hormone receptors. When this occurs, the hormones aren't allowed to work at optimal levels, leaving you feeling sluggish, leading to a higher chance of stress eating, and giving up physical activity.* 

When you're battling adrenal fatigue, it is difficult to lose weight for several reasons. Not only are you exhausted and lack the physical energy to exercise the way that you used to, but those suffering with adrenal fatigue also crave high-fat sweets and salty foods, turning to food as a way to comfort them and aid in assisting their exhausted adrenal glands. The combination of being sedentary, having no energy, and eating chips and cookies makes it seemingly impossible to lose weight, but there is hope, and it can be done without worsening your already delicate state of health and without feeling famished.* 

TLS ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula, specially formulated with Holy basil and Ashwagandha, works specifically to promote healthy adrenal gland function, cortisol levels and thyroid function to help control stress levels and minimize weight gain that is associated with increased stress. Unlike the competitors, TLS ACTS doesn't just mask the problem of weight gain – it addresses the root of the problem by helping your body adapt to stress and assisting you with your weight management goals.*

Frequently Asked Questions about TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula:

How should I take this product?
Take two per day. You may take one pill or both pills at the same time depending on your preference.

What other nutritional supplements could augment the biological effects of this product?
Isotonix® B-Complex and Isotonix Multivitamin.

What are the contraindications for this supplement?
If you are currently taking warfarin (Coumadin), other anti-platelet/anti-coagulant medications, antihypertensive medications, anti-depressants, anti-anxiety medications or have an ongoing medical condition, you should consult your healthcare provider before using this product. If you have hyperthyroidism, you should not take this product. Women who are pregnant or breastfeeding should not use this product. This product may decrease the effects of stimulants and caffeine.

How does it promote relaxation without making you tired?

The Siberian Ginseng and the Ashwaganadha are natural stimulants. They reduce your stress levels but aren’t formulated to make you drowsy. Ginseng acts similar to caffeine but doesn’t make you jittery and won’t deplete your energy.

Can I take TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula instead of my prescription?

No. TLS ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula is not intended to replace any prescription medication. TLS ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula is a natural reliever of sudden stress. It is intended for use during or after engaging in stressful activities. You should contact your doctor before changing or discontinuing the use of any prescription medications.*

If I am on a prescription for anxiety, is it safe to use TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula?

You should consult your doctor before taking any dietary supplement. The ingredients in TLS Adrenal, Cortisol, Thyroid & Stress Support Formula may have side effects, so make sure to contact your doctor before mixing them.

What is the relationship between Cortisol and the Thyroid?

Cortisol levels have a direct relationship with the thyroid, and they act synergistically with one another. Cortisol assists the thyroid hormone in working more efficiently. The correct amount of cortisol – not too high or too low – supports normal thyroid function. When cortisol gets too high, triggered by the adrenal glands' response to unwanted stress, it causes a delayed or absent response from the tissues to the thyroid hormone signal. This absent or delayed response from the tissues causes resistance from the thyroid hormone receptors. When cortisol gets too high, and this resistance occurs, it requires more hormones to create the same effect. That’s why elevated stress, which elevates cortisol levels, leads to a sluggish feeling. The hormones aren’t allowed to work at optimal levels. Every cell in the body has receptors for both cortisol and thyroid and nearly every cellular process requires an optimal functioning thyroid.*  

How does TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula support weight management?
When our bodies experience stress, we switch into 'fight or flight' mode – our body’s response to perceived threat or danger. As a result, our bodies prepare to be sustained by building up 'energy' (aka, fat) and strength for the battle. This response used to be beneficial to our ancestors, but now this response can be triggered in not so appropriate situations and repetitively. Stress can physically cause us to put on extra weight — and keep it there. Whenever we are under stress, our bodies release certain hormones by the adrenal gland — adrenalin and cortisol, cortisol being the primary stress hormone. Cortisol is a potent signal to do two things — increase appetite and store fat. Increased cortisol in our body tells our brain that we're hungry, while at the same time telling our fat cells to store and hold onto as much fat as they can. TLS Adrenal, Cortisol, Thyroid and Stress Support Formula is a natural dietary supplement designed to help the body adapt to stress, promoting healthy levels of cortisol while enhancing and stabilizing mood, and supporting thyroid function.*

Primary Benefits of TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula:

• Acts as an adaptogen, allowing a body to appropriately respond to stress placed on it
• Impacts hormones affected by stress
• Helps body adapt to stress
• May help reduce occasional fatigue associated with stress
• May help to minimize certain stress-related issues (weight gain, difficulty sleeping, etc.)
• Helps to reduce stress placed on the adrenals to perform, thereby helping to decrease the possibility of adrenal fatigue
• May help to support normal hypothalamic-pituitary adrenal (HPA) functions
• May help support normal thyroid function
• Helps to promote healthy levels of cortisol
• Helps maintain healthy levels of both serotonin and dopamine
• Helps enhance and stabilize mood
• Helps to stabilize emotional responses to stress
• May help to maintain normal thyroid function
• Promotes relaxation without drowsiness
• Supports improved mental clarity

Key Ingredients Found in TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula:

Sensoril® Trim/Ashwagandha root extract: 450 mg

Ashwagandha has antioxidant and sedative properties. It has been proven to act as an adaptogen by helping to inhibit occasional fatigue, boost energy, promote emotional well-being and counteract the negative effects of stress. Preliminary evidence suggests ashwagandha helps to regulate stress-induced levels of dopamine receptors in the corpus striatum of the brain. It also appears to promote normal levels of plasma corticosterone, blood urea nitrogen and blood lactic acid. Acting as an adaptogen, ashwagandha reduces stress placed on adrenals to perform, thereby helping to decrease the possibility of adrenal fatigue. Though the exact mechanisms by which ashwagandha works are unknown, one hypothesis is that it functions by way of GABA-mimetic activity which acts independently of GABA receptors. In addition to its adaptogenic properties, ashwagandha may promote normal regulation of thyroid function. It has been shown to promote healthy serum levels of the thyroid hormones triodothyronine (T₃) and thyroxine (T₄), both of which are important in promoting normal metabolism.  

Holy Basil: 375 mg

Holy basil has adaptogenic and calming activities. Research shows holy basil may help to promote normal plasma corticosterone levels and hepatic and renal functions, help maintain normal blood glucose levels and inhibit several other stress-related issues. Though the exact mechanism of action is not known, it is believed that much of holy basil's effect on stress comes from its high content of eugenol, caryophyllene and triterpenoic acids, such as ursolic and oleanolic acids. Studies have shown eugenol to be effective at promoting normal cyclooxygenase 2 (COX 2), an enzyme involved with the inflammatory response. 

L-Theanine: 200 mg

L-Theanine is an amino acid found in green tea and some mushrooms. Preliminary evidence suggests that l-theanine might induce subjective feelings of tranquility in healthy people. It is believed that l-theanine may work by promoting normal levels of the neurotransmitters GABA (Gamma Amino Butyric Acid) and dopamine in the central nervous system. GABA is the primary inhibitory neurotransmitter which promotes calimg effects at the cellular level. Dopamine aids in the regulation of many functions within the brain in regards to behavior, cognition, sleep, mood, attention and memory, and is often associated with the ‘reward’ or ‘pleasure’ center of the brain. 

Passion Flower Extract: 200 mg

Passion flower has sedative and relaxation effects. Some studies have pointed to the flavonoids in passion flower such as apigenin, vitexin and isovitexin as the primary constituents responsible for its effects. Research suggests apigenin can bind to central benzodiazepine receptors in the brain, possibly causing relaxation and helping regulate mood without impairing memory or motor skills.

 
Bacopin® (Bacopa monniera Leaf): 150 mg

Bacopa monniera, also referred to as brahmi, has a long history of use in Ayurvedic health for memory enhancement, support of learning and mood enhancement. Constituents of bacopa, specifically bacosides A and B, have been shown to support learning ability, cognitive performance and improve mood. Bacopa also contains the flavonoids apigenin and luteolin. Research suggests apigenin can bind to central benzodiazepine receptors in the brain, possibly causing relaxation and helping regulate mood without impairing memory or motor skills. 

Rhodiola rosea Root Extract: 150 mg

Rhodiola, or roseroot, acts as an antioxidant and adaptogen, promotes relaxation and mental clarity, and helps to improve mood. Research suggests that salidroside, one of over 30 compounds found in rhodiola, is responsible for its stimulating and adaptogenic effects. Within the brain, rhodiola appears to influence the level, activity and transport of monoamine neurotransmitters, such as dopamine, epinephrine and norepinephrine, and serotonin. Rhodiola has been proposed to promote healthy neurotransmitter levels.

Iodine: 150 mcg

The most important function of iodine is promoting normal thyroid function and contributing to the body’s normal production of thyroid hormones. Iodine is absolutely crucial in maintaining optimal thyroid health.

Eleuthero Root (Eleutherococcus senticosus) Extract: 100 mg
Research has shown that eleuthero root, also known as 'Siberian ginseng,' has antioxidant, adaptogenic, sedative, as well as many other effects. As an adaptogen, it helps promote the normal regulation of the endocrine system's response to stressors. The active compounds in eleuthero root, eleutherosides, are believed to stimulate the pituitary-adrenocortical system allowing for more efficient regulation of the stress response and healthy levels of cortisol. Other research suggests that it may help to support feelings of well-being, reduce occasional fatigue and improve memory and cognitive performance.

Scientific Support for TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula:                                           

• Archana, R., et al.  Antistressor effect of Withania somnifera.  Journal of Ethnopharmacology.  64(1): 91-93, 1999.
• Bhattacharya, S., et al.  Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress.  Pharmacology  Biochemistry and Behavior.  75(3): 547-555, 2003.
• Davydov, M. and Krikorian, A. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. Journal of Ethnopharmacology. 72: 345-393, 2000.
• Dhuley, J.  Effect of ashwagandha on lipid peroxidation in stress-induced animals.  Journal of Ethnopharmacology.  60(2): 173-178, 1998.
• Dhuley, J. Adaptogenic and cardioprotective action of ashwagandha in rats and frogs. Journal of Ethnopharmacology. 70(1): 57-63, 2000.
• Head, K. and Kelly, G. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep.  Alternative Medicine Review.  14(2): 114-140, 2009.
• Gaffney, B., et al.  Panax ginseng and Eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors.  Medical Hypotheses.  56(5): 567-572, 2001.
• Kelly, G. Nutritional and botanical interventions to assist with the adaptation to stress. Alt Med Review 4: 249-265, 1999.
• Muruganandam A., et al. Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Indian Journal of Experimental Biology. 40:1151-1160, 2002.
• Rai, D. Adaptogenic effect of Bacopa monniera (Brahmi). Pharmacology  Biochemistry and Behavior.  75(4): 823-830, 2003.
• Singh, S. and Majumdar, D. Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). Journal of Ethnopharmacology. 65: 13-19, 1999.
• Spasov, A. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 7(2): 85-89, 2000.
• Muruganandam A., et al. Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Indian Journal of Experimental Biology. 40: 1151-1160, 2002.
• Head, K. and Kelly, G. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep.  Alternative Medicine Review.  14(2): 114-140, 2009.
• Ito, K., et al.  Effects of L-theanine on the release of alpha brain waves in human volunteers.  Nippon Nogeikagaku Kaishi. 72: 153-157, 1998.
• L-theanine Monograph. Alternative Medicine Review. 10(2): 136-138, 2005.
• Yokogoshi, H.  Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochemical Research. 23(5): 667-673, 1998.
• Akhondzadeh, S., et al.  Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam.  Journal of Clinical Pharmacy and Therapeutics.  26(5): 363-367, 2001.
• Archana, R., et al.  Antistressor effect of Withania somnifera.  Journal of Ethnopharmacology.  64(1): 91-93, 1999.
• Bhattacharya, S., et al.  Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study.  Phytomedicine.  7(6): 463-469, 2000.
• Dhawan, K., et al.  Anti-anxiety studies on extracts of Passiflora incarnata Linneaus.  Journal of Ethnopharmacology..  78(2-3): 165-170, 2001.
• Dhuley, J. Adaptogenic and cardioprotective action of ashwagandha in rats and frogs. Journal of Ethnopharmacology. 70(1): 57-63, 2000.
• Head, K. and Kelly, G. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep.  Alternative Medicine Review.  14(2): 114-140, 2009.
• Kobayashi, K., et al.  Effects of L-theanine on the release of alpha-brain waves in human volunteers.  Journal of the Agricultural Chemical Society of Japan.  72(2): 153-157, 1998.
• Muruganandam A., et al. Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Indian Journal of Experimental Biology. 40: 1151-1160, 2002.
• Sairam K., et al. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine. 9(3): 207-211, 2002.
• Dufresne, C. and Farnworth, E. A review of latest research findings on the health promotion properties of tea. The Journal of Nutritional Biochemistry. 12(7): 404-421, 2001.
• Ito, K., et al.  Effects of L-theanine on the release of alpha brain waves in human volunteers.  Nippon Nogeikagaku Kaishi.  72: 153-157, 1998.
• Lu, K., et al. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Human Psychopharmacology. 19(7): 457-465, 2004.
• Bacopa monniera. Monograph. Alternative Medicine Review. 9: 79-85, 2004. 
• L-theanine Monograph. Alternative Medicine Review. 10(2): 136-138, 2005.
• Spasov, A. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 7(2): 85-89, 2000.
• Gohil KJ, Patel JA. A review on Bacopa monniera: Current research and future prospects. International Journal of Green Pharmacy. 4(1):1-9, 2010.
• Kar, A., et al. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in mice.  Journal of Ethnopharmacology. 81(2): 281-285, 2002.
• Khanum, F., et al.  Rhodiola rosea: a versatile adaptogen.  Comprehensive Reviews in Food Science and Food Safety.  4:55-62, 2005.
• Panda, S. and Kar, A.  Changes in thyroid hormone concentration after administration of ashwagandha root extract to adult male mice. Journal of Pharmacy and Pharmacology.  50(9): 1065-1068, 1998.
• Panda, S. and Kar, A.  Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Journal of Ethnopharmacology.  67(2): 233-239, 1999.
• Panda, S. and Kar, A. combined effects of ashwagandha, guggulu and bauhinia extracts in the regulation of thyroid function and on lipid peroxidation in mice.  Journal of Pharmacy and Pharmacology.  6(3): 141-143, 2000.

What Makes TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula Unique?

Your job demands a lot of your time. Your family demands just as much, if not more. Trips to the mailbox are greeted by bills. Every day, life is taking its toll on you. Even in seemingly good times, stress is something we cannot escape; not only does it have a harmful affect on us mentally, but it can also wreck havoc on us physically – including on our waistlines.*

When we are faced with stress, our bodies go into "fight or flight" response and certain hormones are released by the adrenal gland, hormones that would give the body a burst of energy and strength. This response used to be beneficial to our ancestors, allowing their bodies to physically fight or run away when faced with danger. But in today’s society, this response acts much differently, taking place as a result of stressful days at the office or traffic jam on your way home. The response is supposed to return to normal once the perceived threat is gone, but if the body is unable to return to normalcy due to increased stress levels, it could have a negative effect upon the body with symptoms including adrenal fatigue, suppressed thyroid function, an imbalance in blood sugar levels, and increased abdominal (adipose) fat.*

One of the hormones released during this “fight or flight” response is cortisol, which increases blood sugar, suppresses the immune system, and aids in fat, protein and carbohydrate metabolism. Under normal circumstances, cortisol helps restore homeostasis after stress. The problem is that constant stress leads to a constant state of cortisol production, which stimulates glucose production. This excess glucose is typically converted into fat, ending up as stored fat. High cortisol levels can also lead to binge eating. Not only do high cortisol levels make you want to keep on snacking, but excess cortisol also contributes to storing more belly fat, which is known to be a bit harder to lose.* 

Cortisol levels also have a direct relationship with the thyroid, and they act synergistically with one another. Cortisol assists the thyroid hormone in working more efficiently, and the correct amount of cortisol – not too high or too low – supports normal thyroid function. When cortisol gets too high, triggered by the adrenal glands response to elevated stress, it causes a delayed response to the thyroid hormone receptors. When this occurs, the hormones aren't allowed to work at optimal levels, leaving you feeling sluggish, leading to a higher chance of stress eating, and giving up physical activity.* 

When you're battling adrenal fatigue, it is difficult to lose weight for several reasons. Not only are you exhausted and lack the physical energy to exercise the way that you used to, but those suffering with adrenal fatigue also crave high-fat sweets and salty foods, turning to food as a way to comfort them and aid in assisting their exhausted adrenal glands. The combination of being sedentary, having no energy, and eating chips and cookies makes it seemingly impossible to lose weight, but there is hope, and it can be done without worsening your already delicate state of health and without feeling famished.* 

TLS ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula, specially formulated with Holy basil and Ashwagandha, works specifically to promote healthy adrenal gland function, cortisol levels and thyroid function to help control stress levels and minimize weight gain that is associated with increased stress. Unlike the competitors, TLS ACTS doesn't just mask the problem of weight gain – it addresses the root of the problem by helping your body adapt to stress and assisting you with your weight management goals.*

Frequently Asked Questions about TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula:

How should I take this product?
Take two per day. You may take one pill or both pills at the same time depending on your preference.

What other nutritional supplements could augment the biological effects of this product?
Isotonix® B-Complex and Isotonix Multivitamin.

What are the contraindications for this supplement?
If you are currently taking warfarin (Coumadin), other anti-platelet/anti-coagulant medications, antihypertensive medications, anti-depressants, anti-anxiety medications or have an ongoing medical condition, you should consult your healthcare provider before using this product. If you have hyperthyroidism, you should not take this product. Women who are pregnant or breastfeeding should not use this product. This product may decrease the effects of stimulants and caffeine.

How does it promote relaxation without making you tired?

The Siberian Ginseng and the Ashwaganadha are natural stimulants. They reduce your stress levels but aren’t formulated to make you drowsy. Ginseng acts similar to caffeine but doesn’t make you jittery and won’t deplete your energy.

Can I take TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula instead of my prescription?

No. TLS ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula is not intended to replace any prescription medication. TLS ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula is a natural reliever of sudden stress. It is intended for use during or after engaging in stressful activities. You should contact your doctor before changing or discontinuing the use of any prescription medications.*

If I am on a prescription for anxiety, is it safe to use TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula?

You should consult your doctor before taking any dietary supplement. The ingredients in TLS Adrenal, Cortisol, Thyroid & Stress Support Formula may have side effects, so make sure to contact your doctor before mixing them.

What is the relationship between Cortisol and the Thyroid?

Cortisol levels have a direct relationship with the thyroid, and they act synergistically with one another. Cortisol assists the thyroid hormone in working more efficiently. The correct amount of cortisol – not too high or too low – supports normal thyroid function. When cortisol gets too high, triggered by the adrenal glands' response to unwanted stress, it causes a delayed or absent response from the tissues to the thyroid hormone signal. This absent or delayed response from the tissues causes resistance from the thyroid hormone receptors. When cortisol gets too high, and this resistance occurs, it requires more hormones to create the same effect. That’s why elevated stress, which elevates cortisol levels, leads to a sluggish feeling. The hormones aren’t allowed to work at optimal levels. Every cell in the body has receptors for both cortisol and thyroid and nearly every cellular process requires an optimal functioning thyroid.*  

How does TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula support weight management?
When our bodies experience stress, we switch into 'fight or flight' mode – our body’s response to perceived threat or danger. As a result, our bodies prepare to be sustained by building up 'energy' (aka, fat) and strength for the battle. This response used to be beneficial to our ancestors, but now this response can be triggered in not so appropriate situations and repetitively. Stress can physically cause us to put on extra weight — and keep it there. Whenever we are under stress, our bodies release certain hormones by the adrenal gland — adrenalin and cortisol, cortisol being the primary stress hormone. Cortisol is a potent signal to do two things — increase appetite and store fat. Increased cortisol in our body tells our brain that we're hungry, while at the same time telling our fat cells to store and hold onto as much fat as they can. TLS Adrenal, Cortisol, Thyroid and Stress Support Formula is a natural dietary supplement designed to help the body adapt to stress, promoting healthy levels of cortisol while enhancing and stabilizing mood, and supporting thyroid function.*