Primary Benefits of Prime™ Joint Support Formula by Isotonix®*:
Supports relief from temporary inflammation associated with the normal aging process and daily activity
Helps maintain healthy joint fluidity and flexibility
Promotes normal cartilage synthesis and regeneration
Promotes optimal joint health
Helps maintain joint comfort
Supports normal, healthy levels of COX-2 and 5-LOX
↓ More ↓
↑ Less ↑
Key Ingredients Found in Prime™ Joint Support Formula by Isotonix®:
Glucosamine (HCl): 1000 mg Glucosamine is a molecule that is naturally synthesized in the body from glucose and the amino acid glutamine. Glucosamine is an important constituent of glycosaminoglycans in cartilage matrix and synovial fluid. As our bodies age, we are less able to produce glucosamine, resulting in cartilage that is less flexible and weak. Although the mechanism is currently unclear, studies have shown that glucosamine supplementation can support normal, healthy cartilage cell production to help maintain overall joint health. Pine Bark Extract (Pycnogenol®): 25 mg Pycnogenol is a water-soluble, flavonoid complex with powerful benefits. Pycnogenol, similar to the proanthocyanins found in grape seeds, is extracted from the bark of the French Maritime Pine tree. Numerous studies have examined the anti-inflammatory properties of Pycnogenol.
The body’s inflammatory response is a natural process. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help maintain the body’s natural defenses by inhibiting over active inflammatory responses associated with the normal aging process. Research has shown that Pycnogenol may inhibit the activation of NF-kappa B and AP-1, both of which are proinflammatory mediators. Pycnogenol supplementation can also promote normal COX-2 and 5-LOX gene expression, and support healthy leukotriene biosynthesis. In addition, studies have shown the ability of Pycnogenol to cross-link collagen fibers and strengthen connective tissue proteins.
To learn more about the relationship between Pycnogenol and joint health, follow the links below to read the full text studies.
Hyaluronic Acid (Sodium Hyaluronate): 25 mg Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Although it is produced naturally by the body, the level of hyaluronic acid diminishes with age, contributing to joint discomfort. It is a key component of cartilage, and is important for skin, joint and eye health. Hyaluronic acid has been shown to help maintain strong, healthy cartilage. It may also enhance synovial fluid production and promote normal healing.
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Scientific Support for Prime™ Joint Support Formula by Isotonix®:
Belcaro, G., et al. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®. Redox Report. 13(6): 271-276, 2008.
Blewis, M., et al. A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials. 13: 26-39, 2007.
Braham, R., et al. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 37(1): 45-49, 2003.
Canali, R., et al. The anti-inflammatory pharmacology of Pycnogenol® in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. International Immunopharmacology. 9(10): 1145-1149, 2009.
Chang, X., et al. Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis. Arthritis Research and Therapy. 7(2): R268-R273, 2005.
Chou, M., et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Experimental Biology and Medicine. 230(4): 255-262, 2005.
Cisár, P., et al. Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis. Phytotherapy Research. 22: 1087-1092, 2008.
Elliott, A., et al. Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project. Arthritis and Rheumatism. 52(1): 105-111, 2005.
Farid, R., et al. Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research. 27: 692-697, 2007.
Gaby, A. Natural treatments for osteoarthritis. Alternative Medicine Review. 4(5): 330-341, 1999.
Gouze, J., et al. Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Research and Therapy. 8(6): R173
Grimm, T., et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®). Journal of Inflammation. 3: 1-15, 2006.
Hua, J., et al. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. Journal of Leukocyte Biology. 71(4): 632-640, 2002.
James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
Julovi, S., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis and Rheumatism. 50(2): 516-525, 2004.
Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
Kelly, G. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alternative Medicine Review. 3(1): 27-39, 1998.
McDonald, J. and Levick, J. Hyaluronan reduces fluid escape rate from rabbit knee joints disparately from its effect on fluidity. Experimental Physiology. 79(1): 103-106, 1994.
Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
Ohno, S., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. Journal of Biological Chemistry. 281(26): 17952-17960, 2006.
Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
Reginster, J., et al. Current concepts in the therapeutic management of osteoarthritis with glucosamine. Bulletin (Hospital for Joint Disease). 63(1-2): 31-36, 2005.
Reginster, J., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet. 357(9252): 251-256, 2001.
Richy, F., et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 163(13): 1514-1522, 2003.
Santangelo, K., et al. Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cells. Arthritis Research and Therapy. 9(1): R1, 2007.
Sasaki, A., et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. The Tohoku Journal of Experimental Medicine. 204(2): 99-107, 2004.
Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.
↓ More ↓
↑ Less ↑
What Makes Prime™ Joint Support Formula by Isotonix® Unique?
As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the market: glucosamine, chondroitin and methylsulfonylmethane, more commonly referred to as MSM.
The research on both chondroitin and MSM is very controversial. Chondroitin, for instance, has very poor absorption due to its high molecular weight. Also, one of chondroitin’s mechanisms is to increase the hyaluronic acid content of synovial fluid; while the new Prime Joint Support Formula by Isotonix directly provides hyaluronic acid. Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Likewise, research on MSM is not conclusive. In fact, it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.*
On the other hand, the research behind glucosamine is consistent and its benefits effective. Prime Joint Support Formula contains glucosamine, naturally produced by the body and a key component of cartilage. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage, and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage.*
Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown to inhibit the body’s over-active inflammatory processes associated with the normal aging process.
The body’s inflammatory response is a natural process. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help support the body’s defense system by inhibiting over active inflammatory responses associated with the normal aging process. To learn more the relationship between Pycnogenol and joint health, click the links below to access the full text studies.
Furthermore, Prime Joint Support Formula is the only product on the market delivering glucosamine, Pycnogenol and hyaluronic acid in isotonic form.*
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.
Isotonix® dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
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Frequently Asked Questions about Prime™ Joint Support Formula by Isotonix®:
How should Prime Joint Support Formula by Isotonix be taken? On an empty stomach, take two capfuls daily or as directed by your healthcare professional.
What other products should I take with Prime Joint Support Formula by Isotonix to support my joint health? Heart Health™ Essential Omega III is a great pair with Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.
How often should I take Prime Joint Support Formula by Isotonix? This product is most effective when taken daily.
How much Pycnogenol® is in Prime Joint Support Formula by Isotonix? There are 25 milligrams of Pycnogenol in each daily serving.
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13081_Label.jpg
↓ More ↓
↑ Less ↑
Primary Benefits of Prime™ Joint Support Formula by Isotonix®*:
Supports relief from temporary inflammation associated with the normal aging process and daily activity
Helps maintain healthy joint fluidity and flexibility
Promotes normal cartilage synthesis and regeneration
Promotes optimal joint health
Helps maintain joint comfort
Supports normal, healthy levels of COX-2 and 5-LOX
Key Ingredients Found in Prime™ Joint Support Formula by Isotonix®:
Glucosamine (HCl): 1000 mg Glucosamine is a molecule that is naturally synthesized in the body from glucose and the amino acid glutamine. Glucosamine is an important constituent of glycosaminoglycans in cartilage matrix and synovial fluid. As our bodies age, we are less able to produce glucosamine, resulting in cartilage that is less flexible and weak. Although the mechanism is currently unclear, studies have shown that glucosamine supplementation can support normal, healthy cartilage cell production to help maintain overall joint health. Pine Bark Extract (Pycnogenol®): 25 mg Pycnogenol is a water-soluble, flavonoid complex with powerful benefits. Pycnogenol, similar to the proanthocyanins found in grape seeds, is extracted from the bark of the French Maritime Pine tree. Numerous studies have examined the anti-inflammatory properties of Pycnogenol.
The body’s inflammatory response is a natural process. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help maintain the body’s natural defenses by inhibiting over active inflammatory responses associated with the normal aging process. Research has shown that Pycnogenol may inhibit the activation of NF-kappa B and AP-1, both of which are proinflammatory mediators. Pycnogenol supplementation can also promote normal COX-2 and 5-LOX gene expression, and support healthy leukotriene biosynthesis. In addition, studies have shown the ability of Pycnogenol to cross-link collagen fibers and strengthen connective tissue proteins.
To learn more about the relationship between Pycnogenol and joint health, follow the links below to read the full text studies.
Hyaluronic Acid (Sodium Hyaluronate): 25 mg Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Although it is produced naturally by the body, the level of hyaluronic acid diminishes with age, contributing to joint discomfort. It is a key component of cartilage, and is important for skin, joint and eye health. Hyaluronic acid has been shown to help maintain strong, healthy cartilage. It may also enhance synovial fluid production and promote normal healing.
Scientific Support for Prime™ Joint Support Formula by Isotonix®:
Belcaro, G., et al. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®. Redox Report. 13(6): 271-276, 2008.
Blewis, M., et al. A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials. 13: 26-39, 2007.
Braham, R., et al. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 37(1): 45-49, 2003.
Canali, R., et al. The anti-inflammatory pharmacology of Pycnogenol® in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. International Immunopharmacology. 9(10): 1145-1149, 2009.
Chang, X., et al. Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis. Arthritis Research and Therapy. 7(2): R268-R273, 2005.
Chou, M., et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Experimental Biology and Medicine. 230(4): 255-262, 2005.
Cisár, P., et al. Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis. Phytotherapy Research. 22: 1087-1092, 2008.
Elliott, A., et al. Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project. Arthritis and Rheumatism. 52(1): 105-111, 2005.
Farid, R., et al. Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research. 27: 692-697, 2007.
Gaby, A. Natural treatments for osteoarthritis. Alternative Medicine Review. 4(5): 330-341, 1999.
Gouze, J., et al. Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Research and Therapy. 8(6): R173
Grimm, T., et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®). Journal of Inflammation. 3: 1-15, 2006.
Hua, J., et al. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. Journal of Leukocyte Biology. 71(4): 632-640, 2002.
James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
Julovi, S., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis and Rheumatism. 50(2): 516-525, 2004.
Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
Kelly, G. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alternative Medicine Review. 3(1): 27-39, 1998.
McDonald, J. and Levick, J. Hyaluronan reduces fluid escape rate from rabbit knee joints disparately from its effect on fluidity. Experimental Physiology. 79(1): 103-106, 1994.
Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
Ohno, S., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. Journal of Biological Chemistry. 281(26): 17952-17960, 2006.
Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
Reginster, J., et al. Current concepts in the therapeutic management of osteoarthritis with glucosamine. Bulletin (Hospital for Joint Disease). 63(1-2): 31-36, 2005.
Reginster, J., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet. 357(9252): 251-256, 2001.
Richy, F., et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 163(13): 1514-1522, 2003.
Santangelo, K., et al. Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cells. Arthritis Research and Therapy. 9(1): R1, 2007.
Sasaki, A., et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. The Tohoku Journal of Experimental Medicine. 204(2): 99-107, 2004.
Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.
What Makes Prime™ Joint Support Formula by Isotonix® Unique?
As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the market: glucosamine, chondroitin and methylsulfonylmethane, more commonly referred to as MSM.
The research on both chondroitin and MSM is very controversial. Chondroitin, for instance, has very poor absorption due to its high molecular weight. Also, one of chondroitin’s mechanisms is to increase the hyaluronic acid content of synovial fluid; while the new Prime Joint Support Formula by Isotonix directly provides hyaluronic acid. Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Likewise, research on MSM is not conclusive. In fact, it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.*
On the other hand, the research behind glucosamine is consistent and its benefits effective. Prime Joint Support Formula contains glucosamine, naturally produced by the body and a key component of cartilage. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage, and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage.*
Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown to inhibit the body’s over-active inflammatory processes associated with the normal aging process.
The body’s inflammatory response is a natural process. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help support the body’s defense system by inhibiting over active inflammatory responses associated with the normal aging process. To learn more the relationship between Pycnogenol and joint health, click the links below to access the full text studies.
Furthermore, Prime Joint Support Formula is the only product on the market delivering glucosamine, Pycnogenol and hyaluronic acid in isotonic form.*
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.
Isotonix® dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
Frequently Asked Questions about Prime™ Joint Support Formula by Isotonix®:
How should Prime Joint Support Formula by Isotonix be taken? On an empty stomach, take two capfuls daily or as directed by your healthcare professional.
What other products should I take with Prime Joint Support Formula by Isotonix to support my joint health? Heart Health™ Essential Omega III is a great pair with Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.
How often should I take Prime Joint Support Formula by Isotonix? This product is most effective when taken daily.
How much Pycnogenol® is in Prime Joint Support Formula by Isotonix? There are 25 milligrams of Pycnogenol in each daily serving.
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Top Selling Products
Top Market America Products
A sampling of Market America's best-selling products can be found in this section.
Market AmericaPrime Joint Support Formula by Isotonix
4.1
(based on 15 reviews)
Ratings Distribution
5 Stars
(6)
4 Stars
(7)
3 Stars
(0)
2 Stars
(1)
1 Stars
(1)
87%
of respondents would recommend this to a friend.
Pros
Simple to take (6)
Increases flexibility (5)
Good value (4)
Relieves pain (4)
Cons
Best Uses
Everyday use (7)
Older people (4)
Athletes (3)
Injury recovery (3)
Reviewer Profile:
First time user (6), Health conscious (4)
Most Helpful Positive Review
Let the games begin!!!
Well, Market America, I got the first bottle in the mail today! I took the first dose as soon as I got near some water!!!! Surprisingly good taste, not mediciny, chalky...Read complete review
Well, Market America, I got the first bottle in the mail today! I took the first dose as soon as I got near some water!!!! Surprisingly good taste, not mediciny, chalky or gritty! I have been in pain for over 35yrs. I will keep you posted on each bottles effects on me. I want to be your biggest fan. To those that have lost much, triumph is all the more sweeter!!!
VS
Most Helpful Negative Review
joint support
no difference from what I was taking and 10 times as expensive. very difficult to pore into small cap tops without spilling. could not recommend and will not renew.
no difference from what I was taking and 10 times as expensive. very difficult to pore into small cap tops without spilling. could not recommend and will not renew.
Comments about Market America Prime Joint Support Formula by Isotonix:
To whom it May Concern,
I think this formula works very well. I will be ordering it for myself this month. But, I would like to see less repetative information in the description of the product benefits and usefulness. And possibly more information about where it works in the body and how it actually maintains the functioning of the joints.
Thank you,
11/2/2011
(1 of 1 customers found this review helpful)
4.0
Prime Time
By Mitch
from Woodhaven, NY
About Me Health Conscious
Pros
Feel better
Increases Flexibility
Simple To Take
Tastes good tastes fine
Cons
If stiff hard to measure
Best Uses
Early morning
Everyday Use
Older People
Comments about Market America Prime Joint Support Formula by Isotonix:
Pain might prevent using the cap for measuring on very cold days when the stiffness increases.
Otherwise an EXCELLENT supplement.
10/31/2011
4.0
too early to really feel any difference!
By Jim
from Middleburng, Virginis USA
About Me First Time User, Health Conscious
Pros
Cons
Best Uses
Everyday Use
Comments about Market America Prime Joint Support Formula by Isotonix:
Difficult to travel with product. Should just put the powder in capsules and make taking and carrying so easy! We had a very lovely, knowledgable sales rep! We would recommend her to everyone and anyone! Thanks, Jim Burns
9/15/2011
(2 of 2 customers found this review helpful)
5.0
Relief worth every penny!
By Ivy J
from Wisconsin
About Me First Time User, Health Conscious
Pros
Good Value
Increases Flexibility
Relieves Pain
Simple To Take
Cons
Best Uses
Athletes
Everyday Use
Injury Recovery
Older People
Comments about Market America Prime Joint Support Formula by Isotonix:
This product is so easy to take once in the morning with my other Isotonics. I was taking tablets three times a day, sometimes forgetting. I did get better relief with this product and did not have to wait several days to start noticing! I highly recommend this product to anyone with joint issues.
9/9/2011
(1 of 5 customers found this review helpful)
1.0
Not Worth The Price - DOES NOT WORK!!!!
By DistinctLady
from Poughkeepsie, NY
About Me First Time User
Pros
Cons
Not worth the price
Best Uses
None
Comments about Market America Prime Joint Support Formula by Isotonix:
Does not work, the price is too high and not worth the value.
7/18/2011
(2 of 6 customers found this review helpful)
2.0
joint support
By bill schmidt
from lansdale, pa.
About Me First Time User
Pros
Cons
No Long-Term Help
Best Uses
Comments about Market America Prime Joint Support Formula by Isotonix:
no difference from what I was taking and 10 times as expensive. very difficult to pore into small cap tops without spilling. could not recommend and will not renew.
7/5/2011
(3 of 3 customers found this review helpful)
4.0
Prime Joint Support Formula
By Jeff
from Warren, NH
About Me Construction worker, Regular User
Pros
Good Value
Increases Flexibility
No more more AM stiffness
Simple To Take
Cons
Best Uses
Athletes
Everyday Use
Injury Recovery
Older People
Comments about Market America Prime Joint Support Formula by Isotonix:
After taking the Joint Support for about 3 days, I noticed that my morning stiffness had dissapeared. I will not be without it ever again!
7/5/2011
(4 of 4 customers found this review helpful)
4.0
simplify your life
By Chris
from Butler, NJ
About Me First Time User, Health Conscious
Pros
Good Value
Relieves Pain
Simple To Take
Cons
Best Uses
Athletes
Everyday Use
Injury Recovery
Comments about Market America Prime Joint Support Formula by Isotonix:
I replaced my glucosamine/chondroitin/msm formula and my anti-inflammatory with Prime Joint Support Formula. Not only did I trade two supplements for one, I also traded taking pills throughout the day with one dose in the morning. I am recovering from a knee injury, and it is helping.
6/8/2011
(2 of 2 customers found this review helpful)
5.0
Love this product!!!!
By Kim
from Farimount, ND
About Me Regular User
Pros
Good Value
Increases Flexibility
Increases Strength
Relieves Pain
Simple To Take
Cons
Best Uses
Everyday Use
Comments about Market America Prime Joint Support Formula by Isotonix:
I take every morning and my joints feel great after taking product. I have nothing bad to say about this product..it is amazing!!!!!!!
3/2/2011
(10 of 10 customers found this review helpful)
5.0
My results are amazing!
By Cayte
from NYC & New Port Richey, FL
About Me First Time User
Pros
Increases Flexibility
Increases Strength
Quick results
Relieves Pain
Simple To Take
Cons
None
Best Uses
Everyday Use
Older People
Comments about Market America Prime Joint Support Formula by Isotonix:
Prime Joint Support Formula by Isotonix is amazing. I used to think I had good results from Market America's Glucosatrin product - and I did, compared to how my knees felt when I wasn't taking it. But for me, there is a major difference for the better with the Prime Joint. My knees feel more flexible, they don't scream at me anymore when I'm on stairs and I don't have a constant fear of them buckling under me. Whoo-hoo! Way to go MA!
Customer Managers are Independent Distributors of Market America products
Prime Joint Support Formula by Isotonix
Single Bottle - (45 Servings)
$73.50
$1.47 Cashback
Primary Benefits of Prime™ Joint Support Formula by Isotonix®*:
Supports relief from temporary inflammation associated with the normal aging process and daily activity
Helps maintain healthy joint fluidity and flexibility
Promotes normal cartilage synthesis and regeneration
Promotes optimal joint health
Helps maintain joint comfort
Supports normal, healthy levels of COX-2 and 5-LOX
Key Ingredients Found in Prime™ Joint Support Formula by Isotonix®:
Glucosamine (HCl): 1000 mg Glucosamine is a molecule that is naturally synthesized in the body from glucose and the amino acid glutamine. Glucosamine is an important constituent of glycosaminoglycans in cartilage matrix and synovial fluid. As our bodies age, we are less able to produce glucosamine, resulting in cartilage that is less flexible and weak. Although the mechanism is currently unclear, studies have shown that glucosamine supplementation can support normal, healthy cartilage cell production to help maintain overall joint health. Pine Bark Extract (Pycnogenol®): 25 mg Pycnogenol is a water-soluble, flavonoid complex with powerful benefits. Pycnogenol, similar to the proanthocyanins found in grape seeds, is extracted from the bark of the French Maritime Pine tree. Numerous studies have examined the anti-inflammatory properties of Pycnogenol.
The body’s inflammatory response is a natural process. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help maintain the body’s natural defenses by inhibiting over active inflammatory responses associated with the normal aging process. Research has shown that Pycnogenol may inhibit the activation of NF-kappa B and AP-1, both of which are proinflammatory mediators. Pycnogenol supplementation can also promote normal COX-2 and 5-LOX gene expression, and support healthy leukotriene biosynthesis. In addition, studies have shown the ability of Pycnogenol to cross-link collagen fibers and strengthen connective tissue proteins.
To learn more about the relationship between Pycnogenol and joint health, follow the links below to read the full text studies.
Hyaluronic Acid (Sodium Hyaluronate): 25 mg Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Although it is produced naturally by the body, the level of hyaluronic acid diminishes with age, contributing to joint discomfort. It is a key component of cartilage, and is important for skin, joint and eye health. Hyaluronic acid has been shown to help maintain strong, healthy cartilage. It may also enhance synovial fluid production and promote normal healing.
Scientific Support for Prime™ Joint Support Formula by Isotonix®:
Belcaro, G., et al. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®. Redox Report. 13(6): 271-276, 2008.
Blewis, M., et al. A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials. 13: 26-39, 2007.
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What Makes Prime™ Joint Support Formula by Isotonix® Unique?
As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the market: glucosamine, chondroitin and methylsulfonylmethane, more commonly referred to as MSM.
The research on both chondroitin and MSM is very controversial. Chondroitin, for instance, has very poor absorption due to its high molecular weight. Also, one of chondroitin’s mechanisms is to increase the hyaluronic acid content of synovial fluid; while the new Prime Joint Support Formula by Isotonix directly provides hyaluronic acid. Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Likewise, research on MSM is not conclusive. In fact, it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.*
On the other hand, the research behind glucosamine is consistent and its benefits effective. Prime Joint Support Formula contains glucosamine, naturally produced by the body and a key component of cartilage. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage, and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage.*
Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown to inhibit the body’s over-active inflammatory processes associated with the normal aging process.
The body’s inflammatory response is a natural process. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help support the body’s defense system by inhibiting over active inflammatory responses associated with the normal aging process. To learn more the relationship between Pycnogenol and joint health, click the links below to access the full text studies.
Furthermore, Prime Joint Support Formula is the only product on the market delivering glucosamine, Pycnogenol and hyaluronic acid in isotonic form.*
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.
Isotonix® dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
Frequently Asked Questions about Prime™ Joint Support Formula by Isotonix®:
How should Prime Joint Support Formula by Isotonix be taken? On an empty stomach, take two capfuls daily or as directed by your healthcare professional.
What other products should I take with Prime Joint Support Formula by Isotonix to support my joint health? Heart Health™ Essential Omega III is a great pair with Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.
How often should I take Prime Joint Support Formula by Isotonix? This product is most effective when taken daily.
How much Pycnogenol® is in Prime Joint Support Formula by Isotonix? There are 25 milligrams of Pycnogenol in each daily serving.
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