Primary Benefits of Prime™ Cognitin™ Memory Support Formula*:
Aids in improving and enhancing memory
Helps maintain healthy blood circulation within the brain (cerebral blood flow)
Helps maintain normal brain physiology
Helps minimize the effects of aging on the brain
Inhibits oxidative stress on the brain
Promotes healthy levels of acetylcholine (an important neurotransmitter in the brain)
Supports normal mental activity
Supports overall cognitive performance
Promotes learning capacity
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↑ Less ↑
Key Ingredients Found In Prime™ Cognitin™ Memory Support Formula:
Acetyl L-Carnitine: 500 mg
Acetyl L-Carnitine (ALC)is able to travel through the blood-brain barrier where it supports the normal formation of the brain chemical acetylcholine; it promotes the efficient operation of cells by helping them stay clear of toxic fatty-acid metabolites; and it helps maintain normal brain physiology.*
Chemical messengers like neurotransmitters are vital to maintaining cognitive function yet often decline with age. Studies have shown that ALC promotes overall cognitive performance. ALC promotes normal cognitive function by helping to maintain brain energy production, phospholipid metabolism and acetyl coenzyme A levels. Acetyl coenzyme A is used by the body to re-synthesize acetylcholine.*
Alpha-lipoic acid: 100 mg
Deep within the tissue, alpha-lipoic acid is a coenzyme that, together with pyrophosphatase, promotes normal carbohydrate metabolism and production of adenosine triphosphate (ATP). Deep within the tissues of the brain, alpha-lipoic acid and the metabolite, dihydrolipoic acid (DHLA), have antioxidant components, which help to neutralize damaging free radicals.*
Alpha-lipoic acid is both water and fat-soluble and can regenerate endogenous antioxidants, such as vitamin E, vitamin C, and glutathione, and prevent oxidative stress. Alpha-lipoic acid is about 30 percent absorbed from dietary or supplemental sources and is reduced to DHLA in many tissues.*
Vinpocetine (Viagra for the Brain): 20 mg Vinpocetine appears to have antioxidant components and supports normal blood flow, which may be beneficial to healthy brain function. Preliminary evidence indicates that vinpocetine supports cerebral circulation and promotes glucose and oxygen consumption by the brain. Vinpocetine's age management benefits may include improved concentration.*
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Scientific Studies Which Support Prime™ Cognitin™ Memory Support Formula:
Acetyl-L-Carnitine and Alpha-Lipoic Acid: A Possible Anti-aging CombinationAug 2002, Vol. 8, No. 4: 242-245
Balestreri, R., et al.A double-blind placebo controlled evaluation of the safety and efficacy of vinpocetine in the treatment of patients with chronic vascular senile cerebral dysfunction.J Am Geriatric Society.35(5):425-430, 1987.
Bhatti, J., et al.Vinpocetinee effects on cognitive impairments produced by flunitrazepam.Int Clin Psychopharmacol.2:325-331, 1987.
Bigini, P., et al.Acetyl-L-carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons.Neurosci Lett.329:334, 2002
Calvani, M., et al.Action of acetyl-L-carnitine in neurodegeneration and Alzheimer’s disease.Annals of the New York Academy of Sciences (USA).663:483-486, 1993.
Coleston, D. M., et al.Possible memory-enhancing properties of vinpocetine.Drug Dev Res.14:191-193, 1988.
De Simone, R., et al.Effect of acetyl-L-carnitine on forebrain cholinergic neurons of developing rats.Int J Dev Neurosci.9(1):39-46, 1991.
DeNoble, V. J.Vinpocetine enhances retrieval of a step-through passive avoidance response in rats.Pharmacol Biochem Behav.26(1):183-186, 1987.
DeNoble, V. J., et al.Vinpocetine: nootropic effects on scopolamine-induced and hypoxia-induced retrieval deficits of a step-through passive avoidance response in rats.Pharmacology, Biochemistry and Behavior.24(4):1123-1128, 1986.
Farr, S. A., et al.The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.J Neurochem.84(5):1173-1183, 2003.
Formenti, A., et al.Effects of acetyl-L-carnitine on the survival of adult rat sensory neurons in primary cultures.Int J Dev Neurosci.10:207-214, 1992.
Hagen, T. M., et al.Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.Proc Natl Acad Sci USA.99(4):1870-1875, 2002.
Liu, J., et al.Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.Proc Natl Acad Sci USA.99(4):2356-2361, 2002.
Liu, J., et al. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci 1033:117-31, 2004.
Manconi, E., et al.A double-blind clinical trial of vinpocetine in the treatment of cerebral insufficiency of vascular and degenerative origin.Curr Ther Res Clin Exp.40:702-709, 1986.
Mayeux R and Sano M. Treatment of Alzheimer's Disease. N Engl J Med 341:1670-9, 1999.
McKay Hart, A., et al.Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment.Neurosci Lett.334:181-185, 2002.
Miyamoto, M., et al.Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.J Pharmacol Exp Ther.250:1132-1140, 1989.
Napoleone, P., et al.Age-dependent nerve cell loss in the brain of Sprague-Dawley rats: effect of long term acetyl-L-carnitine treatment.Arch Gerontol Geriatr.10:173-185, 1990.
Packer, L., et al.Alpha-lipoic acid as a biological antioxidant.Free Rad Biol Med.19:227-250, 1995
Passeri M., et al. Acetyl-L-carnitine in the treatment of mildly demented elderly patients. Int J Clin Pharmacol Res 10:75-9. 1990.
Polich J. and Gloria R. Cognitive effects of a Ginkgo biloba/vinpocetine compound in normal adults: systematic assessment of perception, attention and memory. Hum Psychopharmacol 16:409-16, 2001.
Postiglione, A., et al. Effect of acute administration of L-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct. Pharmacol Res 23:241-6, 1991
Ramacci, M. T., et al.Effect of long-term treatment with acetyl-L-carnitine on structural changes of ageing rat brain.Drugs Exp Clin Res.14(9):593-601, 1988.
Reed, K. W., et al.Acetylcarnitine and cholinergic receptors.J Pharm Sci.69:1065-1068, 1980.
Salvioli, G. and Neri, M. L-acetylcarnitine treatment of mental decline in the elderly. Drugs Exp Clin Res 20:169-76, 1994.
Santos, M., et al.Synaptosomal response to oxidative stress: effect of vinpocetine.Free Radic Res.32:57-66, 2000.
Stoll, S., et al.The potent free radical scavenger alpha-lipoic acid improves memory in aged mice:putative relationship to NMDA receptor deficits.Pharm Biochem Behav.46:799-805, 1993.
Subhan, Z., et al.Psychopharmacological effects of vinpocetine in normal healthy volunteers.Eur J Clin Pharmacol.28(5):567-571, 1985.
Taglialatela, G., et al.Neurite outgrowth in PC12 cells stimulated by acetyl-L-carnitine arginine amide.Neurochem Res.20:1-9, 1995.
Valerio, C., et al.The effects of acetyl-L-carnitine on experimental models of learning and memory deficits in the old rat.Funct Neurol.4:387-390, 1989.
Wolz, P., et al.Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and protein oxidation in various brain regions of aged rats.J Nutr Biochemistry.13:619-624, 2002.
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What Makes Prime™ Cognitin™ Memory Support Formula Unique?
As we go through our busy days, we have a lot to think about. Unfortunately, as we age, the ability to retain our memories sometimes fades. At times, even the simplest things — names, events or tasks that we would have had no problem remembering a few years ago — seem to completely slip our minds. Cognitin is specially designed to help maintain healthy blood circulation within the brain. Maintaining proper blood flow to the brain is important in maintaining proper brain function.*
Cognitin has a select ingredient combination to enhance memory and inhibit oxidative stress to the brain. Alpha-lipoic acid has antioxidant activity that can scavenge free radicals in the brain to stop the undesirable chain reaction they cause. Alpha-lipoic acid is both water and fat soluble, and can regenerate endogenous antioxidants, such as vitamin E, vitamin C, and glutathione, and inhibit oxidative stress. Vinpocetine and acetyl l-carnitine help maintain healthy blood circulation in the brain. Cognitin is specially formulated to promote proper blood flow to the brain in order for the brain to maintain peak performance and to infuse the brain with antioxidants to inhibit free radicals activity in the brain.*
↓ More ↓
↑ Less ↑
Frequently Asked Questions About Prime™ Cognitin™ Memory Support Formula:
If I am taking OPC-3®, can I take Cognitin™?
The combination of the ingredient vinpocetine and OPC-3 may cause blood thinning, so if you are currently taking warfarin (Coumadin), other antiplatelet/anticoagulant, antidiabetic, chemotherapy or any other prescription drugs, or have an ongoing medical condition, you should consult your physician before taking this product.
I get sick taking pills on an empty stomach. Can I take this with food?
Cognitin should be taken with food to improve absorption of the active ingredients.
If I am already taking Vitamind, can I also take Cognitin?
The combination of Vitamind and Cognitin is not necessary or recommended.The vinpocetine in Cognitin may interact with the Ginkgo Biloba in Vitamind and may cause the blood to thin.
What other products complement Cognitin?
Isotonix® Maximum ORAC, Isotonix Multivitamin, Heart Health Advanced CoQ10 and Isotonix Advanced B-Complex all complement Cognitin to produce optimal memory levels.
What portion of the brain does Cognitin affect*?
The entire brain.
What mechanisms does this formulation work by*?
Aids in improving and enhancing memory
Supports normal mental activity
Inhibits oxidative stress on the brain
Helps maintain healthy blood circulation within the brain (cerebral blood flow)
Helps maintain normal brain physiology
Supports overall cognitive performance
Promotes healthy levels of acetylcholine (an important neurotransmitter in the brain)
Helps minimize the effects of aging on the brain
When should I start to see a difference?
Possibly within two weeks.
↓ More ↓
↑ Less ↑
13095_Label.jpg
↓ More ↓
↑ Less ↑
Primary Benefits of Prime™ Cognitin™ Memory Support Formula*:
Aids in improving and enhancing memory
Helps maintain healthy blood circulation within the brain (cerebral blood flow)
Helps maintain normal brain physiology
Helps minimize the effects of aging on the brain
Inhibits oxidative stress on the brain
Promotes healthy levels of acetylcholine (an important neurotransmitter in the brain)
Supports normal mental activity
Supports overall cognitive performance
Promotes learning capacity
Key Ingredients Found In Prime™ Cognitin™ Memory Support Formula:
Acetyl L-Carnitine: 500 mg
Acetyl L-Carnitine (ALC)is able to travel through the blood-brain barrier where it supports the normal formation of the brain chemical acetylcholine; it promotes the efficient operation of cells by helping them stay clear of toxic fatty-acid metabolites; and it helps maintain normal brain physiology.*
Chemical messengers like neurotransmitters are vital to maintaining cognitive function yet often decline with age. Studies have shown that ALC promotes overall cognitive performance. ALC promotes normal cognitive function by helping to maintain brain energy production, phospholipid metabolism and acetyl coenzyme A levels. Acetyl coenzyme A is used by the body to re-synthesize acetylcholine.*
Alpha-lipoic acid: 100 mg
Deep within the tissue, alpha-lipoic acid is a coenzyme that, together with pyrophosphatase, promotes normal carbohydrate metabolism and production of adenosine triphosphate (ATP). Deep within the tissues of the brain, alpha-lipoic acid and the metabolite, dihydrolipoic acid (DHLA), have antioxidant components, which help to neutralize damaging free radicals.*
Alpha-lipoic acid is both water and fat-soluble and can regenerate endogenous antioxidants, such as vitamin E, vitamin C, and glutathione, and prevent oxidative stress. Alpha-lipoic acid is about 30 percent absorbed from dietary or supplemental sources and is reduced to DHLA in many tissues.*
Vinpocetine (Viagra for the Brain): 20 mg Vinpocetine appears to have antioxidant components and supports normal blood flow, which may be beneficial to healthy brain function. Preliminary evidence indicates that vinpocetine supports cerebral circulation and promotes glucose and oxygen consumption by the brain. Vinpocetine's age management benefits may include improved concentration.*
Scientific Studies Which Support Prime™ Cognitin™ Memory Support Formula:
Acetyl-L-Carnitine and Alpha-Lipoic Acid: A Possible Anti-aging CombinationAug 2002, Vol. 8, No. 4: 242-245
Balestreri, R., et al.A double-blind placebo controlled evaluation of the safety and efficacy of vinpocetine in the treatment of patients with chronic vascular senile cerebral dysfunction.J Am Geriatric Society.35(5):425-430, 1987.
Bhatti, J., et al.Vinpocetinee effects on cognitive impairments produced by flunitrazepam.Int Clin Psychopharmacol.2:325-331, 1987.
Bigini, P., et al.Acetyl-L-carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons.Neurosci Lett.329:334, 2002
Calvani, M., et al.Action of acetyl-L-carnitine in neurodegeneration and Alzheimer’s disease.Annals of the New York Academy of Sciences (USA).663:483-486, 1993.
Coleston, D. M., et al.Possible memory-enhancing properties of vinpocetine.Drug Dev Res.14:191-193, 1988.
De Simone, R., et al.Effect of acetyl-L-carnitine on forebrain cholinergic neurons of developing rats.Int J Dev Neurosci.9(1):39-46, 1991.
DeNoble, V. J.Vinpocetine enhances retrieval of a step-through passive avoidance response in rats.Pharmacol Biochem Behav.26(1):183-186, 1987.
DeNoble, V. J., et al.Vinpocetine: nootropic effects on scopolamine-induced and hypoxia-induced retrieval deficits of a step-through passive avoidance response in rats.Pharmacology, Biochemistry and Behavior.24(4):1123-1128, 1986.
Farr, S. A., et al.The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.J Neurochem.84(5):1173-1183, 2003.
Formenti, A., et al.Effects of acetyl-L-carnitine on the survival of adult rat sensory neurons in primary cultures.Int J Dev Neurosci.10:207-214, 1992.
Hagen, T. M., et al.Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.Proc Natl Acad Sci USA.99(4):1870-1875, 2002.
Liu, J., et al.Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.Proc Natl Acad Sci USA.99(4):2356-2361, 2002.
Liu, J., et al. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci 1033:117-31, 2004.
Manconi, E., et al.A double-blind clinical trial of vinpocetine in the treatment of cerebral insufficiency of vascular and degenerative origin.Curr Ther Res Clin Exp.40:702-709, 1986.
Mayeux R and Sano M. Treatment of Alzheimer's Disease. N Engl J Med 341:1670-9, 1999.
McKay Hart, A., et al.Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment.Neurosci Lett.334:181-185, 2002.
Miyamoto, M., et al.Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.J Pharmacol Exp Ther.250:1132-1140, 1989.
Napoleone, P., et al.Age-dependent nerve cell loss in the brain of Sprague-Dawley rats: effect of long term acetyl-L-carnitine treatment.Arch Gerontol Geriatr.10:173-185, 1990.
Packer, L., et al.Alpha-lipoic acid as a biological antioxidant.Free Rad Biol Med.19:227-250, 1995
Passeri M., et al. Acetyl-L-carnitine in the treatment of mildly demented elderly patients. Int J Clin Pharmacol Res 10:75-9. 1990.
Polich J. and Gloria R. Cognitive effects of a Ginkgo biloba/vinpocetine compound in normal adults: systematic assessment of perception, attention and memory. Hum Psychopharmacol 16:409-16, 2001.
Postiglione, A., et al. Effect of acute administration of L-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct. Pharmacol Res 23:241-6, 1991
Ramacci, M. T., et al.Effect of long-term treatment with acetyl-L-carnitine on structural changes of ageing rat brain.Drugs Exp Clin Res.14(9):593-601, 1988.
Reed, K. W., et al.Acetylcarnitine and cholinergic receptors.J Pharm Sci.69:1065-1068, 1980.
Salvioli, G. and Neri, M. L-acetylcarnitine treatment of mental decline in the elderly. Drugs Exp Clin Res 20:169-76, 1994.
Santos, M., et al.Synaptosomal response to oxidative stress: effect of vinpocetine.Free Radic Res.32:57-66, 2000.
Stoll, S., et al.The potent free radical scavenger alpha-lipoic acid improves memory in aged mice:putative relationship to NMDA receptor deficits.Pharm Biochem Behav.46:799-805, 1993.
Subhan, Z., et al.Psychopharmacological effects of vinpocetine in normal healthy volunteers.Eur J Clin Pharmacol.28(5):567-571, 1985.
Taglialatela, G., et al.Neurite outgrowth in PC12 cells stimulated by acetyl-L-carnitine arginine amide.Neurochem Res.20:1-9, 1995.
Valerio, C., et al.The effects of acetyl-L-carnitine on experimental models of learning and memory deficits in the old rat.Funct Neurol.4:387-390, 1989.
Wolz, P., et al.Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and protein oxidation in various brain regions of aged rats.J Nutr Biochemistry.13:619-624, 2002.
What Makes Prime™ Cognitin™ Memory Support Formula Unique?
As we go through our busy days, we have a lot to think about. Unfortunately, as we age, the ability to retain our memories sometimes fades. At times, even the simplest things — names, events or tasks that we would have had no problem remembering a few years ago — seem to completely slip our minds. Cognitin is specially designed to help maintain healthy blood circulation within the brain. Maintaining proper blood flow to the brain is important in maintaining proper brain function.*
Cognitin has a select ingredient combination to enhance memory and inhibit oxidative stress to the brain. Alpha-lipoic acid has antioxidant activity that can scavenge free radicals in the brain to stop the undesirable chain reaction they cause. Alpha-lipoic acid is both water and fat soluble, and can regenerate endogenous antioxidants, such as vitamin E, vitamin C, and glutathione, and inhibit oxidative stress. Vinpocetine and acetyl l-carnitine help maintain healthy blood circulation in the brain. Cognitin is specially formulated to promote proper blood flow to the brain in order for the brain to maintain peak performance and to infuse the brain with antioxidants to inhibit free radicals activity in the brain.*
Frequently Asked Questions About Prime™ Cognitin™ Memory Support Formula:
If I am taking OPC-3®, can I take Cognitin™?
The combination of the ingredient vinpocetine and OPC-3 may cause blood thinning, so if you are currently taking warfarin (Coumadin), other antiplatelet/anticoagulant, antidiabetic, chemotherapy or any other prescription drugs, or have an ongoing medical condition, you should consult your physician before taking this product.
I get sick taking pills on an empty stomach. Can I take this with food?
Cognitin should be taken with food to improve absorption of the active ingredients.
If I am already taking Vitamind, can I also take Cognitin?
The combination of Vitamind and Cognitin is not necessary or recommended.The vinpocetine in Cognitin may interact with the Ginkgo Biloba in Vitamind and may cause the blood to thin.
What other products complement Cognitin?
Isotonix® Maximum ORAC, Isotonix Multivitamin, Heart Health Advanced CoQ10 and Isotonix Advanced B-Complex all complement Cognitin to produce optimal memory levels.
What portion of the brain does Cognitin affect*?
The entire brain.
What mechanisms does this formulation work by*?
Aids in improving and enhancing memory
Supports normal mental activity
Inhibits oxidative stress on the brain
Helps maintain healthy blood circulation within the brain (cerebral blood flow)
Helps maintain normal brain physiology
Supports overall cognitive performance
Promotes healthy levels of acetylcholine (an important neurotransmitter in the brain)
Helps minimize the effects of aging on the brain
When should I start to see a difference?
Possibly within two weeks.
↓ More ↓
↑ Less ↑
Top Selling Products
Top Market America Products
A sampling of Market America's best-selling products can be found in this section.
Comments about Market America Cognitin™ Cognitive Support Formula:
I was wonderfully surprised at how fast acting and powerful this product works. I live on vitamin supplements, tried many on the market and found this supplement to be one of the better memory support products out. I was experiencing brain fog, problems recalling names, etc. I don't have that problem anymore. I'm almost out and need to buy another bottle. I don't want to run out because its that good.
7/8/2010
(6 of 7 customers found this review helpful)
5.0
Dad, 87, has solution to Gulf oil spill
By Art, the son and co-conspirator
from Shrewsbury, MA
About Me First Time User
Pros
Works Quickly
Cons
Best Uses
Before Sleep
Comments about Market America Cognitin™ Cognitive Support Formula:
I bought this product 6 weeks ago for my father, 87, who had experienced some memory lapses lately. He takes the product at night before he sleeps. Three weeks ago in his rest home apartment, he handed me 6 or 7 pieces of paper that contained diagrams and text as to how workers in the Gulf could contain and capture the leaking oil by relieving the pressure with a series of "capping" towers that would lead to ships that would collect the oil. He wrote to the governor of Louisiana to pass this infomation to engineers and other experts to see if it had merit. "If it works, all I'm asking for is $50 million," he wrote. Now I can't say for sure that Cognitin was THE factor that prompted him to take action, but he's certainly taken a greater interest in what's happening in the Gulf, and he's been writing and calling news stations (CNN, MSNBC, Glenn Beck, Fox News, etc.), and will share his solution to the problem to anyone who will listen. The residents of the rest home know his solution all too well by now. I think my dad is already counting ways he can spend that $50 million. God knows he needs a new pair of sneakers!
6/23/2010
(1 of 2 customers found this review helpful)
4.0
Very good product
By Mikhail
from Portland OR
About Me First Time User
Pros
Good Value
Cons
Results Fade Over Time
Best Uses
Morning
Comments about Market America Cognitin™ Cognitive Support Formula:
I like all this stuff!
6/26/2009
(1 of 1 customers found this review helpful)
4.0
Memory in a capsu;e.
By Patti
from Boynton Beach, Fla.
Pros
Cons
Best Uses
Daily Use
Comments about Market America Cognitin™ Cognitive Support Formula:
I use Cognitin for mental clarity. However, I would appreciate it being in a powder or tablet form. Many thanks for all your great products.
9/28/2008
(7 of 9 customers found this review helpful)
5.0
CAN'T SAY ENOUGH GOOD THINGS!!
By Darlene
from Red Lion, Pa
Pros
Boosts Memory
Nutritional
Think Clearly
Works Quickly
Cons
Best Uses
Daily Use
Comments about Market America Cognitin™ Cognitive Support Formula:
I take this in the morning with my other supplements. Helps me stay focused and clear headed for the entire day. I can really tell if I forget to take it for a day or two. I can't live without this great product. Not to mention I couldn't find my keys or glasses!!
9/10/2008
(5 of 10 customers found this review helpful)
5.0
Great product! It works...
By Jason
from Columbus Ohio
Pros
Long-Lasting Energy
Nutritional
Works Quickly
Cons
Best Uses
Daily Use
Quick Boost
Comments about Market America Cognitin™ Cognitive Support Formula:
Customer Managers are Independent Distributors of Market America products
Prime™ Cognitin™ Memory Support Formula
Single Bottle (30 Servings)
$36.75
$0.74 Cashback
Primary Benefits of Prime™ Cognitin™ Memory Support Formula*:
Aids in improving and enhancing memory
Helps maintain healthy blood circulation within the brain (cerebral blood flow)
Helps maintain normal brain physiology
Helps minimize the effects of aging on the brain
Inhibits oxidative stress on the brain
Promotes healthy levels of acetylcholine (an important neurotransmitter in the brain)
Supports normal mental activity
Supports overall cognitive performance
Promotes learning capacity
Key Ingredients Found In Prime™ Cognitin™ Memory Support Formula:
Acetyl L-Carnitine: 500 mg
Acetyl L-Carnitine (ALC)is able to travel through the blood-brain barrier where it supports the normal formation of the brain chemical acetylcholine; it promotes the efficient operation of cells by helping them stay clear of toxic fatty-acid metabolites; and it helps maintain normal brain physiology.*
Chemical messengers like neurotransmitters are vital to maintaining cognitive function yet often decline with age. Studies have shown that ALC promotes overall cognitive performance. ALC promotes normal cognitive function by helping to maintain brain energy production, phospholipid metabolism and acetyl coenzyme A levels. Acetyl coenzyme A is used by the body to re-synthesize acetylcholine.*
Alpha-lipoic acid: 100 mg
Deep within the tissue, alpha-lipoic acid is a coenzyme that, together with pyrophosphatase, promotes normal carbohydrate metabolism and production of adenosine triphosphate (ATP). Deep within the tissues of the brain, alpha-lipoic acid and the metabolite, dihydrolipoic acid (DHLA), have antioxidant components, which help to neutralize damaging free radicals.*
Alpha-lipoic acid is both water and fat-soluble and can regenerate endogenous antioxidants, such as vitamin E, vitamin C, and glutathione, and prevent oxidative stress. Alpha-lipoic acid is about 30 percent absorbed from dietary or supplemental sources and is reduced to DHLA in many tissues.*
Vinpocetine (Viagra for the Brain): 20 mg Vinpocetine appears to have antioxidant components and supports normal blood flow, which may be beneficial to healthy brain function. Preliminary evidence indicates that vinpocetine supports cerebral circulation and promotes glucose and oxygen consumption by the brain. Vinpocetine's age management benefits may include improved concentration.*
Scientific Studies Which Support Prime™ Cognitin™ Memory Support Formula:
Acetyl-L-Carnitine and Alpha-Lipoic Acid: A Possible Anti-aging CombinationAug 2002, Vol. 8, No. 4: 242-245
Balestreri, R., et al.A double-blind placebo controlled evaluation of the safety and efficacy of vinpocetine in the treatment of patients with chronic vascular senile cerebral dysfunction.J Am Geriatric Society.35(5):425-430, 1987.
Bhatti, J., et al.Vinpocetinee effects on cognitive impairments produced by flunitrazepam.Int Clin Psychopharmacol.2:325-331, 1987.
Bigini, P., et al.Acetyl-L-carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons.Neurosci Lett.329:334, 2002
Calvani, M., et al.Action of acetyl-L-carnitine in neurodegeneration and Alzheimer’s disease.Annals of the New York Academy of Sciences (USA).663:483-486, 1993.
Coleston, D. M., et al.Possible memory-enhancing properties of vinpocetine.Drug Dev Res.14:191-193, 1988.
De Simone, R., et al.Effect of acetyl-L-carnitine on forebrain cholinergic neurons of developing rats.Int J Dev Neurosci.9(1):39-46, 1991.
DeNoble, V. J.Vinpocetine enhances retrieval of a step-through passive avoidance response in rats.Pharmacol Biochem Behav.26(1):183-186, 1987.
DeNoble, V. J., et al.Vinpocetine: nootropic effects on scopolamine-induced and hypoxia-induced retrieval deficits of a step-through passive avoidance response in rats.Pharmacology, Biochemistry and Behavior.24(4):1123-1128, 1986.
Farr, S. A., et al.The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.J Neurochem.84(5):1173-1183, 2003.
Formenti, A., et al.Effects of acetyl-L-carnitine on the survival of adult rat sensory neurons in primary cultures.Int J Dev Neurosci.10:207-214, 1992.
Hagen, T. M., et al.Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.Proc Natl Acad Sci USA.99(4):1870-1875, 2002.
Liu, J., et al.Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.Proc Natl Acad Sci USA.99(4):2356-2361, 2002.
Liu, J., et al. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci 1033:117-31, 2004.
Manconi, E., et al.A double-blind clinical trial of vinpocetine in the treatment of cerebral insufficiency of vascular and degenerative origin.Curr Ther Res Clin Exp.40:702-709, 1986.
Mayeux R and Sano M. Treatment of Alzheimer's Disease. N Engl J Med 341:1670-9, 1999.
McKay Hart, A., et al.Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment.Neurosci Lett.334:181-185, 2002.
Miyamoto, M., et al.Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.J Pharmacol Exp Ther.250:1132-1140, 1989.
Napoleone, P., et al.Age-dependent nerve cell loss in the brain of Sprague-Dawley rats: effect of long term acetyl-L-carnitine treatment.Arch Gerontol Geriatr.10:173-185, 1990.
Packer, L., et al.Alpha-lipoic acid as a biological antioxidant.Free Rad Biol Med.19:227-250, 1995
Passeri M., et al. Acetyl-L-carnitine in the treatment of mildly demented elderly patients. Int J Clin Pharmacol Res 10:75-9. 1990.
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What Makes Prime™ Cognitin™ Memory Support Formula Unique?
As we go through our busy days, we have a lot to think about. Unfortunately, as we age, the ability to retain our memories sometimes fades. At times, even the simplest things — names, events or tasks that we would have had no problem remembering a few years ago — seem to completely slip our minds. Cognitin is specially designed to help maintain healthy blood circulation within the brain. Maintaining proper blood flow to the brain is important in maintaining proper brain function.*
Cognitin has a select ingredient combination to enhance memory and inhibit oxidative stress to the brain. Alpha-lipoic acid has antioxidant activity that can scavenge free radicals in the brain to stop the undesirable chain reaction they cause. Alpha-lipoic acid is both water and fat soluble, and can regenerate endogenous antioxidants, such as vitamin E, vitamin C, and glutathione, and inhibit oxidative stress. Vinpocetine and acetyl l-carnitine help maintain healthy blood circulation in the brain. Cognitin is specially formulated to promote proper blood flow to the brain in order for the brain to maintain peak performance and to infuse the brain with antioxidants to inhibit free radicals activity in the brain.*
Frequently Asked Questions About Prime™ Cognitin™ Memory Support Formula:
If I am taking OPC-3®, can I take Cognitin™?
The combination of the ingredient vinpocetine and OPC-3 may cause blood thinning, so if you are currently taking warfarin (Coumadin), other antiplatelet/anticoagulant, antidiabetic, chemotherapy or any other prescription drugs, or have an ongoing medical condition, you should consult your physician before taking this product.
I get sick taking pills on an empty stomach. Can I take this with food?
Cognitin should be taken with food to improve absorption of the active ingredients.
If I am already taking Vitamind, can I also take Cognitin?
The combination of Vitamind and Cognitin is not necessary or recommended.The vinpocetine in Cognitin may interact with the Ginkgo Biloba in Vitamind and may cause the blood to thin.
What other products complement Cognitin?
Isotonix® Maximum ORAC, Isotonix Multivitamin, Heart Health Advanced CoQ10 and Isotonix Advanced B-Complex all complement Cognitin to produce optimal memory levels.
What portion of the brain does Cognitin affect*?
The entire brain.
What mechanisms does this formulation work by*?
Aids in improving and enhancing memory
Supports normal mental activity
Inhibits oxidative stress on the brain
Helps maintain healthy blood circulation within the brain (cerebral blood flow)
Helps maintain normal brain physiology
Supports overall cognitive performance
Promotes healthy levels of acetylcholine (an important neurotransmitter in the brain)
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