Prime™ Balance Bone Maintenance Formula
Single Bottle (60 Servings)
$62.75
$1.26 Cashback
Primary Benefits of Prime™ Balance*:
- Adequate calcium and vitamin D as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis later in life
- Supports the maintenance of bones
- Helps to maintain bone mass/structure by promoting healthy osteoclast activity
- Promotes normal bone mineral density
- Helps to increase the absorption and retention of both calcium and magnesium
- Increased calcium intake promotes bone strength in the elderly
- Women with low-bone mass density have been found to be deficient in vitamin B12
- Promotes healthy growth of beneficial bacteria in the colon
- Helps maintain proper levels of beneficial intestinal microflora
- Helps maintains cardiovascular health (provides antioxidant protection of LDL particles)
Key Ingredients Found In Prime™ Balance:
Calcium (calcium carbonate): 250 mg
The bones and teeth contain greater than 99 percent of the calcium in the human body. It is incorporated into hard bone matrix contributing to bone strength and promoting the normal mineralization of bones. Low calcium intake, poor calcium absorption, and/or excessive calcium losses have been associated with osteoporosis. Calcium promotes normal nerve transmission, muscle contraction, vascular contraction, vasodilation, glandular secretion, cell membrane and capillary permeability, enzyme reactions, respiration, renal function and blood coagulation.
Inulin: 3400 mg
Inulin is an oligosaccharide, composed of chains of two to 60 glucose and fructose molecules. It works by promoting the normal absorption of both calcium and magnesium, and supporting bone mineralization, therefore supporting stong bones and bone density. Inulin also serves as a bacterial food in the colon, helping to support healthy subpopulations of bacteria in the colon, as well as ionize calcium and magnesium for uptake. Additionally, because inulin is a soluble fiber, it may help to maintain regular colon health.
GeniVida™: 22.5 mg
GeniVida is genistein, a pure (95%) product produced in Switzerland by a patented process. Genistein is a flavonoid and an isoflavone. It binds weakly to some chromosome-based estrogen receptors, thus supporting normal calcium and mineral retention. It also promotes bone formation, possibly supporting normal serum levels of osteocalcin in postmenopausal women. Genistein appears to directly inhibit osteoclast activity. High intake of soy supports normal parathyroid hormone levels, which may help support normal bone turnover. Invitro tests suggest that genistein may help maintain osteoblasts (the cells responsible for forming bone). GeniVida has also been shown to promote normal collagen formation.
Vitamin D3 (as cholecalciferol): 400 IU
The main function of vitamin D is to help promote normal calcium absorption, which in turn promotes bone strength. Since the majority of the body’s nutrients are absorbed in the lower intestines, vitamin D enhances the efficiency of the intestinal absorption of calcium by promoting the normal production of calcium-binding proteins to support calcium absorption and retention. In addition to strengthening bone, vitamin D may promote muscle strength around the bones.
Magnesium (as magnesium carbonate): 200 mg
Magnesium is involved in the health of bones (64 percent of the body's magnesium is concentrated in the bones). It supports normal bone structure and promotes more than 300 cellular reactions, such as the maintenance of membrane integrity, muscle contraction, nerve conduction, and the regulation of vascular tone. Magnesium deficiency could result in bone loss and skeleton fragility. Post-menopausal women and older man afflicted with osteoporosis have been shown to have significantly lower bone magnesium than healthy women and older men.
Vitamin B12 (as cyanocobalamin): 5 mcg
Vitamin B12 promotes normal homocysteine concentration in blood and supports bone strength (men and women with low-bone mass density have been found to be deficient in B12). Adequate vitamin B12 intake is important for maintaining bone mineral density and bone mineral content, especially in post-menopausal women and older men.
Folic Acid: 100 mcg
Folic acid supplementation may help to prevent osteoporosis by promoting normal homocysteine levels. Homocysteine is a metabolite of the amino acid methionine. It has been implicated in osteoporosis. High homocysteine levels cause osteoporosis by the formation of defective bone. Low levels of folic acid, a homocysteine nutrient, have also been associated with impaired bone health.
Scientific Studies Which Support Prime™ Balance:
- Storm D et al. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism. 83(11):3817-25, 1998.
- Chen Y et al. Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. Journal of Clinical Endocrinology Metabolism. 88:4740-7, 2003.
- Cotter A and Cashman K. Genistein appears to prevent early postmenopausal bone loss as effectively as hormone replacement therapy. Nutrition Reviews. 61(10):346-51, 2003. Review.
- Yamaguchi M. Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis. Yakugaku Zasshi 126(11):1117-37, 2006.
- Ullmann U et al. Bonistein™ (synthetic genistein), a food component in development for a bone health nutraceutical. Journal of Physiology Pharmacology. 56 Suppl 1:79-95, 2005.
- Rude R et al. Magnesium deficiency and osteoporosis: animal and human observations. Journal of Nutritional Biochemistry. 15(12):710-716, 2004.
- Sojka J et al. Magnesium supplementation and osteoporosis. Nutrition Reviews. 53(3):71-74, 1995.
- Setchell K and Lydeking-Olsen E. Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Amerian Journal of Clinical Nutrition. 78:593S-609S, 2003.
- Messina M et al. Skeletal benefits of soy isoflavones: a review of the clinical trial and epidemiologic data. Current Opinion in Clinical Nutrition and Metabolic Care. 7(6):649-58, 2004. Review.
- Scheiber M et al. Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause. 8:384-92, 2001.
- Harkness L et al. Decreased bone resorption with soy isoflavone supplementation in postmenopausal women. Journal of Womens Health (Larchmt). 13(9):1000-7, 2004.
- Rickard D et al. Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors alpha and beta. Journal of Cellular Biochemistry. 89(3):633-646, 2003.
- Albertazzi P. Purified phytoestrogens in postmenopausal bone health: is there a role for genistein? Climacteric. 5:190-6, 2002.
- Zafar T et al. Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats. Journal of Nutrition. 134(2):399-402, 2004.
- Macdonald H et al. Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women. American Journal of Clinical Nutrition. 81(4):923-933, 2005.
- Crisafulli A et al. Effects of the phytoestrogen genistein on the circulating soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin system in early postmenopausal women. Journal of Clinical Endocrinology Metabolism. 89(1):188-92, 2004.
- Roberfroid M et al. Dietary chicory inulin increases whole-body bone mineral density in growing male rats. Journal of Nutrition. 132(12):3599-3602, 2002.
- Sojka J et al. Magnesium supplementation and osteoporosis. Nutrition Reviews. 53(3):71-74, 1995.
- Dhonukshe-Rutten R et al. Vitamin B12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men. Journal of Nutrition. 133(3):801-807, 2003.
- Chen Y et al. Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. Journal of Clinical Endocrinology Metabolism. 88:4740-7, 2003.
- Setchell K and Lydeking-Olsen E. Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Amerian Journal of Clinical Nutrition. 78:593S-609S, 2003.
- Macdonald H et al. Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women. American Journal of Clinical Nutrition. 81(4):923-933, 2005.
- Baines Met al. The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B(12) and vitamin B(6) with bone mineral density in postmenopausal British women. Bone. 2006 [Article in Press].
- Coudray C et al. Stimulatory effect of inulin on intestinal absorption of calcium and magnesium in rats is modulated by dietary calcium intakes short- and long-term balance studies. European Journal of Nutrition. 44(5):293-302, 2005.
- Coudray C et al. Dietary inulin intake and age can significantly affect intestinal absorption of calcium and magnesium in rats: a stable isotope approach. Nutrition Journal. 4:29, 2005.
- Roberfroid M et al. Dietary chicory inulin increases whole-body bone mineral density in growing male rats. Journal of Nutrition. 132(12):3599-3602, 2002.
- Cashman K. A prebiotic substance persistently enhances intestinal calcium absorption and increases bone mineralization in young adolescents. Nutrition Reviews. 64: 189-96, 2006.
- Zafar T et al. Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats. Journal of Nutrition. 134(2):399-402, 2004.
- Heaney R. Calcium needs of the elderly to reduce fracture risk. Journal of the American College of Nutrition. 20(2 Supplement):192S-197S, 2001.
- Reid I. Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: A randomized controlled trial. American Journal of Medicine. 98(4):331-5, 1995.
- Holbrook,T et al. Dietary calcium intake and risk of hip fracture. 14-year prospective population study. Lancet. 2(8619):1046-1049, 1988.
- Chapuy M et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. New England Journal of Medicine. 327(23):1637-1642, 1992.
- Dhonukshe-Rutten R et al. Vitamin B12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men. Journal of Nutrition. 133(3):801-807, 2003.
- Stone K et al. Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: a prospective study. Journal of Clinical Endocrinology Metabolism. 89(3):1217-1221, 2004.
- Baines M et al. The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B(12) and vitamin B(6) with bone mineral density in postmenopausal British women. Bone. 2006 [Article in Press].
- Roberfroid M et al. The bifidogenic nature of chicory inulin and its hydrolysis products. Journal of Nutrition 128:11-9, 1998.
- Roberfroid M. Functional effects of food components and the gastrointestinal system: chicory fructo-oligosaccharides. Nutrition Reviews 54:S38-42, 1996.
- Schultz M et al. Effects of feeding a probiotic preparation (SIM) containing inulin on the severity of colitis and on the composition of the intestinal microflora in HLA-B27 transgenic rats. Clinical and Diagnostic Laboratory Immunology. 11(3):581-587, 2004.
- Rolfe R. The role of probiotic cultures in the control of gastrointestinal health. Journal of Nutrition. 130(Supplement):396S-402S, 2000.
- Gibson G et al. Selective stimulation of bifidobacteria in the human colony by oligofructose and inulin. Gastroenterology. 108:975-982, 1995.
- Gibson G. Dietary modulation of the human gut microflora using the prebiotics oligofructose and inulin. Journal of Nutrition 129: 1438S-1441S, 1999.
- Kapiotis S et al. Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Arteriosclerosis, Thrombosis and Vascular Biology. 17:2868-74, 1997.
- Wiseman H et al. Isoflavone phytoestrogens consumed in soy decrease F2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. American Journal of Clinical Nutrition. 72:395-400, 2000.
- Brighenti F et al. Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. European Journal of Clinical Nutrition. 53(9):726-733, 1999.
- Scheiber M et al. Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause. 8:384-92, 2001.
- Vincent A et al. Genistein, a phytoestrogen, inhibits proliferation of vascular smooth muscle cells: a possible cardioprotective mechanism. Fertility Sterility. 74:S25, 2000.
What Makes Prime™ Balance Unique?
As we age, our bone structure can weaken, and osteoporosis can occur. As cited by the National Osteoporosis Foundation, osteoporosis is defined as a disease characterized by low-bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fractures, especially of the hip, spine and wrist, although any bone can be affected. Osteoporosis is a major public health threat for an estimated 44 million Americans or 55 percent of the people 50 years of age and older. In the U.S., 10 million individuals are estimated to already have the disease and almost 34 million more are estimated to have low-bone mass, placing them at increased risk for osteoporosis. Of the 10 million Americans estimated to have osteoporosis, eight million are women and two million are men.
Prime Balance contains GeniVida™, which is genistein, a pure (95%) product produced in Switzerland by a patented process. Genistein is an isoflavone that belongs to a group of flavonoids. This group of flavonoids is very similar in structure to the natural estrogens we produce in our body. The main source of genistein is soybeans and some legumes. What separates GeniVida from your typical soy isoflavone product is that it contains no soy allergens. Therefore, those with soy allergies may take this product and have no adverse effects.
Prime Balance is for postmenopausal women and older men. Balance is designed to help prevent osteoporosis, support calcium absorption and retention, maintain bone density and support normal mineralization and bone formation.*
Frequently Asked Questions About Prime™ Balance:
Who should take Prime Balance?
You should take Prime Balance if you are a post-menopausal woman or an older man who is experiencing bone loss or loss of bone density. It can also be taken by women or older men who currently have osteoporosis, or if you have a history of osteoporosis in your family.*
Are there any warnings for this product?
Yes. People with a confirmed sensitivity to inulin (fructo-oligosaccharides) or chicory root should not take this product. If you are currently taking Tamoxifen (Nolvadex) or estrogen therapy, consult your physician before using this product. If you have renal failure, cancer or hypothyroidism, you should not use this product. If you are taking any other prescription drugs or have an ongoing medical condition, you should consult your physician before using this product. Take this supplement separately from prescription medications. Women who are pregnant or nursing should not take this product.
When should I expect to notice results?
You should experience results in about four to six weeks.*
How does this product work?
Prime Balance Bone Maintenance Formula helps combat osteoporosis, supports the maintenance of bones, helps to maintain bone mass/structure by promoting healthy osteoclast activity, supports skeletal health and promotes normal bone mineral density. It promotes the normal absorption and retention of both calcium and magnesium. It also helps maintain proper levels of beneficial intestinal microflora and promotes healthy growth of beneficial bacteria in the colon.*
If I already have been diagnosed with osteoporosis, will this product help?
You should consult your physician before taking this product. Prime Balance is intended to help those with osteoporosis and support the maintenance of bones.*
Can I take this product if I am already taking a calcium supplement?
As always, you should consult your physician before taking this product. This product is intended to supplement what your physician has currently suggested for you.
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