Primary Benefits of Might-a-Mins® Spectrum Isotonix® Multivitamin*:

·         Helps promote normal levels of vitamins and minerals in individuals who need neurological, digestive or metabolic support

·         Helps maintain normal production of neurotransmitters

·         Promotes/supports a healthy nervous system

·         Helps maintain brain health

·         Promotes healthy sensory development

·         Provides strong antioxidant defense

·         Combats free radicals

·         Promotes normal tissue and cell growth

·         Provides nutrients essential for numerous body processes

·         Supports optimal immune functions

·         Supports skeletal health and growth

·         Supports healthy teeth and gums

·         Supports growth and strength of teeth and bones

·         Supports cognitive health and development

·         Supports healthy vision and eyes

·         Supports a healthy heart

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Key Ingredients Found In Might-a-Mins^® Spectrum Isotonix^® Multivitamin:

Beta-Carotene: 3750 IU

Beta-carotene is a nutrient found in plants that the body converts into vitamin A. Vitamin A promotes normal cell growth and differentiation in the tissues of the gastrointestinal tract and brain. Children who need neurological, metabolic or digestive support may benefit from beta-carotene because of its ability to promote normal tissue and cell growth and promote healthy sensory development.* 

Vitamin B1 (Thiamin): 10 mg

Vitamin B1 is a water-soluble vitamin that promotes normal processing of carbohydrates, fat, and protein. Every cell of the body requires vitamin B1 to form the fuel the body runs on — adenosine triphosphate (ATP). Vitamin B1 promotes normal functioning of nerve cells and plays an important role in carbohydrate metabolism. B1 helps maintain a healthy nervous system by supporting the normal production of the neurotransmitters acetylcholine and gamma-aminobutyric acid (GABA).

Vitamin B2 (Riboflavin): 10 mg

Vitamin B2 is a water-soluble vitamin that promotes the normal processing of amino acids and fats, activation of vitamin B6 and folic acid, and supports the conversion of carbohydrates into the fuel the body runs on — adenosine triphosphate (ATP). It also promotes healthy red blood cell formation, supports the nervous system, respiration, antibody production and normal human growth.

Niacinamide: 20 mg

Niacin, also known as vitamin B3, supports energy production in the body. It works with vitamin B1 and vitamin B2 to support the release of energy from carbohydrates. Similar to vitamin B6 and folic acid, niacin supports many pathways which help renew the body’s tissues.

P5P (pyridoxal 5 phosphate): 37.5 mg

Pyridoxal-5-phosphate is the active form of vitamin B6. Vitamin B6 is the master vitamin for numerous metabolic pathways in the body. One specific function is that it supports the normal synthesis of neurotransmitters in the brain and peripheral nerve cells, which are critical for the development of language, attention and alertness. B6 also promotes the normal production of glutathione, which is essential for detoxification. P5P promotes healthy sensory development by supporting the normal synthesis of neurotransmitters in the brains of children who need neurological support.*

Pantothenic acid: 15 mg

Pantothenic acid, also called vitamin B5, is a water-soluble vitamin involved in energy production and the formation of the neurotransmitter acetylcholine, which is important for brain health. Pantothenic acid works together with vitamin B1, vitamin B2, and vitamin B3 to make the fuel our body runs on – ATP. It also promotes the normal production, transport, and release of energy from fats.

Vitamin B12 (Methylcobalamin): 10 mcg

Vitamin B12 is a water-soluble vitamin that supports normal nerve cell activity, DNA replication, and production of the mood-affecting substance SAMe (S-adenosyl-L-methionine). B12 promotes normal conversion of sulfur-containing compounds to glutathione, a powerful antioxidant in the body. B12 provides strong antioxidant defense and combats free radicals in children who need neurological, metabolic or digestive support.*

Folinic acid: 300 mcg

Folinic acid is the metabolically active form of folic acid. Folic acid is a B vitamin essential for numerous processes in the body and supports normal development of the nervous system. Additionally, folic acid supports the conversion of sulfur-containing compounds to glutathione. Children who need neurological support can benefit from folic acid’s ability to help maintain the normal production of neurotransmitters and promotes a healthy nervous system.*

Biotin: 150 mcg

Biotin, a water-soluble B vitamin, acts as a coenzyme in the metabolism of protein, fats, and carbohydrates. Biotin also supports various metabolic chemical conversions. Children get the energy they need from food through metabolism, the chemical reactions in the body's cells that convert the fuel from food into the energy needed to do everything from moving to thinking to growing.

Vitamin C: 300 mg

Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that has a number of biological functions. It supports normal tissue repair, healing and immune function. It is also a cofactor for dopamine production. Supplementing with a proven antioxidant, like vitamin C, is helpful in combating free radicals, especially in children who need neurological, metabolic or digestive support. Vitamin C supports glutathione levels, another important antioxidant in the body. Vitamin C’s strong antioxidant protection can support optimal immune function in children who need neurological, metabolic or digestive support.* 

Vitamin D3 (Cholecalciferol): 200 IU

Vitamin D, a powerful antioxidant, promotes proper brain development. It is also helpful promoting normal glutathione levels which assist in detoxification of the body. In addition to supporting strong bone, vitamin D promotes muscle strength and neuromuscular function. The main function of vitamin D is to support normal regulation of serum calcium concentrations. Children who need neurological, metabolic or digestive support have growing bodies that can benefit from Vitamin D3 because it promotes calcium absorption and retention, supports growth and strength of teeth and bones, and supports skeletal health and growth.*

Vitamin E (D-alpha-tocopheryl acetate): 33 IU

Vitamin E is a fat-soluble vitamin proven to be a strong antioxidant. It supports the structural and functional maintenance of skeletal, cardiac and smooth muscle. It also promotes normal formation of red blood cells, supports cardiovascular function and promotes immune health.

Calcium (Carbonate): 100 mg

Calcium is an important mineral which supports numerous body processes including bone development and maintenance, nerve transmission, muscle contraction, vascular contraction, vasodilation, glandular secretion, cell membrane and capillary permeability, enzymatic reactions, respiration, renal function, and blood coagulation. Children who need neurological, metabolic or digestive support have growing bodies that can benefit from calcium because it supports growth and strength of teeth and bones, skeletal health and growth, and healthy teeth and gums.*

Chromium (Amino Acid Chelate): 25 mcg – Chromium is an essential trace mineral that helps maintain normal glucose metabolism and helps maintain normal insulin and serum cholesterol levels. Chromium combines to form glucose tolerance factor or GTF in the body, which supports the actions of insulin in helping to maintain healthy blood sugar levels.

Iodine: 50 mcg

The trace element is also present in more than a hundred enzyme systems such as energy production, nerve function and hair and skin growth. One of iodine’s main functions includes supporting the thyroid gland in producing thyroid hormones thyroxin and tri-iodothyronine, which support the regulation of metabolic rate.

Magnesium (Lactate): 200 mg

Magnesium, an essential mineral, promotes normal function of over 300 enzymes, specifically those enzymes responsible for the production of neurotransmitters in the brain. Magnesium supports a number of other metabolic pathways including bone, protein and fatty acid formation, B vitamin activation, muscle relaxation, blood clotting and formation of adenosine triphosphate. Children who need neurological, metabolic or digestive support have growing bodies that can benefit from magnesium. Not only does it support bone formation, it promotes normal production of neurotransmitters.*

Manganese (Sulfate): 1 mg

Manganese supports normal formation of connective tissue, bones, and blood-clotting factors. It supports fat and carbohydrate metabolism, calcium absorption, and blood sugar regulation. Manganese also promotes normal brain and nerve function. Manganese may promote the normal use of nutrients including biotin, thiamin, ascorbic acid, and choline.

Selenium (Selenomethionine): 55 mcg

In the body, selenium functions as part of an antioxidant enzyme called glutathione peroxidase, as well as supporting normal growth and proper usage of iodine in thyroid functioning. Selenium also supports the antioxidant effect of vitamin E.

Zinc (Sulfate): 15 mg

Zinc is an essential mineral that is a cofactor in nearly 100 enzymes. It supports healing, protein synthesis, brain maintenance and development, cell reproduction, vision, immunity, and protects against free radicals in children who need neurological, metabolic or and digestive support.*

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Scientific Studies Which Support Might-a-Mins^® Spectrum Isotonix^® Multivitamin:

• Adams J et al.  Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder.  Journal of Alternative and Complementary Medicine.  10(6):1033-1039, 2004.
• Adams J et al. Analyses of toxic metals and essential minerals in the hair of Arizona children with autism and associated conditions, and their mothers. Biology Trace Element Research. 110(3):193-209, 2006.
• Adams J. Summary of Biomedical Treatments for Autism. Autism Research Institute Publication. 40 (April), 2007.
• Ah Kang-Yoon S et al.  Relation of short-term pyridoxine-hydrochloride supplementation to plasma vitamin-B6 vitamers and amino acid concentrations in young women.  American Journal of Clinical Nutrition.  55(4):865-872, 1992.
• Ahmed, F., et al. Efficacy of Twice-Weekly Multiple Micronutrient Supplementation for Improving the Hemoglobin and Micronutrient Status of Anemic Adolescent Schoolgirls in Bangladesh. American Journal of Clinical Nutrition. 82:  829 – 835, 2005.
• Alarcon, K., et al. Effects of Separate Delivery of Zinc or Zinc and Vitamin A on Hemoglobin Response, Growth, and Diarrhea in Young Peruvian Children Receiving Iron Therapy for Anemia.  American Journal of Clinical Nutrition. 80: 1276 – 1282, 2004.
• Angley M et al. Children and autism--Part 2--management with complementary medicines and dietary interventions. Australian Family Physician. 36(10):827-30, 2007.
• Anonymous. Vitamin B6 (pyridoxine and pyridoxal 5'-phosphate) - monograph. Alternative Medicine Review. 6(1):87-92, 2001. Review.
• Audhya T. (2002, October).  Laboratory indices of vitamin and mineral deficiency in autism.  Paper presented at the Defeat Autism Now! Conference, San Diego, California.
• Autism Research Institute. http://www.autism.com/ari/. Accessed May and June 2008.
• Baez-Saldana A et al.  Biotin deficiency induces changes in subpopulations of spleen lymphocytes in mice.  American Journal of Clinical Nutrition.  67(3):431-437, 1998.
• Balogh, K., et al. Inhibition of Bacterial Growth in Human Saliva by Vitamins B1, B2, and B6. Journal of Dental Research. 36 (5): 886-891, 1960.
• Baqui, A., et al. Simultaneous Weekly Supplementation of Iron and Zinc Is Associated with Lower Morbidity Due to Diarrhea and Acute Lower Respiratory Infection in Bangladeshi Infants. Journal of Nutrition. 133: 4150-4157, 2003.
• Benton, D., et al.  Thiamine supplementation mood and cognitive functioning.  Psychopharmacology (Berlin).  129(1):66-71, 1997.
• Bhandari, N., et al. Effect of Routine Zinc Supplementation on Pneumonia in Children Aged 6 Months to 3 Years: Randomized Controlled Trial in an Urban Slum. British Medical Journal. 324: 1358-1362, 2002.
• Bhandari, N., et al. Substantial Reduction in Severe Diarrheal Morbidity by Daily Zinc Supplementation in Young North Indian Children.  Pediatrics.  109: 86-92, 2002.
• Black, M., et al. Iron and Zinc Supplementation Promote Motor Development and Exploratory Behavior Among Bangladeshi Infants. American Journal of Clinical Nutrition. 80: 903 – 910, 2004.
• Brouwer, I., et al. Dietary Folate from Vegetables and Citrus Fruit Decreases Plasma Homocysteine Concentrations in Humans in a Dietary Controlled Trial.  Journal of Nutrition. 129: 1135-1139, 1999.
• Bryan, J., et al. Short-Term Folate, Vitamin B-12 or Vitamin B-6 Supplementation Slightly Affects Memory Performance But Not Mood in Women of Various Ages. Journal of Nutrition. 132: 1345-1356, 2002.
• Burton G et al.  Vitamin E:  Antioxidant activity, biokinetics, and bioavailability.  Annual Review Nutrition.  10:357-382, 1992.
• Carter, l., et al. Self-Reported Calcium Intake and Bone Mineral Content in Children and Adolescents. Journal of the American College of Nutrition.  20: 502-509, 2001. 
• Chitchumroonchokchai, C., et al. Xanthophylls and  -Tocopherol Decrease UVB-Induced Lipid Peroxidation and Stress Signaling in Human Lens Epithelial Cells. Journal of Nutrition. 134: 3225-3232, 2004.
• Clark J et al. Symptomatic vitamin A and D deficiencies in an eight-year-old with autism. JPEN Journal of Parenteral and Enteral Nutrition. 17:284-6. 1993.
• DeAnn J et al.  Gut restoration and chronic disease.  Journal of the American Nutraceutical Association.  5(4):20-33, 2002.
• Dietrich, T., et al. Association between Serum Concentrations of 25-Hydroxyvitamin D and Gingival Inflammation. American Journal of Clinical Nutrition. 82: 575 – 580, 2005.
• Diliberto E et al. Multicompartmental secretion of ascorbate and its dual role in dopamine b-hydroxylation.  American Journal of Clinical Nutrition.  54(6 Supplement):1163S-72S, 1991.
• Dodiuk-Gad, R. P., et al. Sustained Effect of Short-term Calcium Supplementation on Bone Mass in Adolescent Girls with Low Calcium Intake. American Journal of Clinical Nutrition. 81: 168 – 174, 2005.
• Dolske M. et al.  A preliminary trial of ascorbic acid as supplemental therapy for autism.  Progress in Neuropsycho-pharmacology and Biological Psychiatry.  17(2):765-774, 1993.
• Earnest, C., et al. Complex Multivitamin Supplementation Improves Homocysteine and Resistance to LDL-C Oxidation. Journal of the American College of Nutrition. 22: 400-407, 2003.
• Engler, M. M., et al. Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation. 108: 1059 – 1063, 2003.
• Etten, E., et al. 1,25-Dihydroxycholecalciferol: Endocrinology Meets the Immune System.  Proceedings of the Nutrition Society.  61: 375-380, 2002.
• Fernandez-Robredo, P., et al. Vitamins C and E Reduce Retinal Oxidative Stress and Nitric Oxide Metabolites and Prevent Ultrastructural Alterations in Porcine Hyperscholesterolemia. Investigative Ophthalmology and Visual Science. 46 (4): 1140-1146, 2005.
• Frei B et al. Ascorbate is an outstanding antioxidant in human blood plasma.  Proceedings of the National Academy of Sciences USA.  86(16):6377-6381, 1989.
• Gardner, J., et al. Zinc Supplementation and Psychosocial Stimulation: Effects on the Development of Undernourished Jamaican Children. American Journal of Clinical Nutrition. 82: 399 – 405, 2005.
• Hall, S. and Greendale, G.  The Relation of Dietary Vitamin C Intake to Bone Mineral Density: Results from the PEPI Study.  Calcified Tissue International. 63: 183-189, 1998.
• Halterman, J., et al. Iron Deficiency and Cognitive Achievement among School-Aged Children and Adolescents in the United States. Pediatrics. 107: 1381 – 1386, 2001.
• Henning S et al.  Glutathione blood levels and other oxidant defense indexes in men fed diets low in vitamin C.  Journal of Nutrition.  121:169-175, 1991.
• Holick, M. Resurrection of Vitamin D Deficiency and Rickets. Journal of Clinical Investigation. 116: 2062-2072, 2006.
• Holick, M. Vitamin D: Importance in the Prevention of Cancers, Type 1 Diabetes, Heart Disease, and Osteoporosis. American Journal of Clinical Nutrition. 79: 362 – 371, 2004.
• James S et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. American Journal of Clinical Nutrition. 80(6):1611-7, 2004.
• Johnston C et al. Vitamin C elevates red blood cell glutathione in healthy adults.  American Journal of Clinical Nutrition.  58(1):103-105, 1993.
• Kelly G. Folates: supplemental forms and therapeutic applications. Alternative Medicine Review. 3:208-20, 1998. Review.
• Kidd P. Autism, an extreme challenge to integrative medicine.  Part II: medical management. Alternative Medicine Review. 7(6):472-499, 2002.
• Kimura,  M., et al.  Methylenetetrahydrofolate Reductase C677T Polymorphism, Folic Acid and Riboflavin are Important Determinants of Genome Stability in Cultured Human Lymphocytes. Journal of  Nutrition. 134(1):48-56, 2004.
• Kirsch M et al. Ascorbate is a potent antioxidant against peroxynitrite-induced oxidation reactions. Evidence that ascorbate acts by re-reducing substrate radicals produced by peroxynitrite.  J Biol Chem.  275(22):16702-16708, 2000.
• Kleijnen J and Knipschild P. Niacin and vitamin B6 in mental functioning: a review of controlled trials in humans. Biological Psychiatry. 29(9):931-41, 1991.
• Kotsanis C et al. Autism – A multidisciplinary approach to treatment. Study Profile, DFW Ear, Nose & Throat Associates. Grapevine TX. No date given.
• Kraus, A., et al. Supplementation with Vitamin C, Vitamin E or ß-Carotene Influences Osmotic Fragility and Oxidative Damage of Erythrocytes of Zinc-Deficient Rats. Journal of Nutrition. 127: 1290-1296, 1997.
• Kuo C et al.  Ascorbic acid, an endogenous factor required for acetylcholine release from the synaptic vesicles.  Japan Journal of Pharmacology.  30(4):481-492, 1980.
• Leggott, P., et al. Effects of Ascorbic Acid Depletion and Supplementation on Periodontal Health and Subgingival Microflora in Humans. Journal of Dental Research. 70: 1531-1536, 1991.
• Lelord G et al.  Effects of pyridoxine and magnesium on autistic symptoms:  initial observations.  Journal of Autism Developmental Disorders.  11(2):219-229, 1981.
• Lenton, Kevin J., et al.  Vitamin C Augments Lymphocyte Glutathione in Subjects with Ascorbate Deficiency. American Journal of Clinical Nutrition. 77: 189 – 195, 2003.
• Levy A and Hyman S. Use of complementary and alternative treatments for children with autistic spectrum disorders is increasing. Pediatric Annals. 32:685-91, 2003.
• Levy S et al. Novel treatments for autistic spectrum disorders. Mental Retardation and Developmental Disabilities Research Reviews. 11(2):131-42, 2005. Review.
• LimeBack, H., et al.  The effects of Hypocalcemia/Hypophosphatemia on Porcine Bone and Dental Hard tissues in an Inherited Form of Type 1 Pseudo-Vitamin D Deficiency Rickets. Journal of Dental Research. 71:346-352, 1992.
• Lonsdale D et al. Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: A pilot study.  Neuroendocrinology Letters.  23(4):303-308, 2002.
• Marlow M et al.  Decreased magnesium in the hair of autistic children.  Journal of Orthomolecular Psychiatry.  13(2):117-122, 1984.
• Martineau J et al.  Vitamin B6, magnesium, and combined B6-Mg:  therapeutic effects in childhood autism.  Biological Psychiatry.  20(5):467-478, 1985.
• Martineau J et al. Brief report: an open middle-term study of combined vitamin B6-magnesium in a subgroup of autistic children selected on their sensitivity to this treatment.  Journal of Autism and Developmental Disorders. 18:435-447, 1988.
• Martineau J et al. Effects of vitamin B6 on averaged evoked potential in infantile autism.  Biological Psychiatry.  16(7):627-641, 1981.
• Martineau J et al. Electrophysiological effects of fenfluramine or combined vitamin B6 and magnesium on children with autistic behavior. Developmental Medicine and Child Neurology. 31:728-736, 1989.
• Matkovic, V., et al.  Calcium Supplementation and Bone Mineral Density in Females from Childhood to Young Adulthood: A Randomized Controlled Trial. American Journal of Clinical Nutrition. 81: 175 – 188, 2005.
• Matsuda, T. and Toda, T. Effects of Vitamin B6 on Dental Caries in Rats.  Journal of Dental Research.  46(6): 1460-1464, 1967.
• McGinnis W. Oxidative stress in autism. Alternative Therapies in Health and Medicine. 10(6):22-36, 2004. Review.
• Megson M. Is autism a G-alpha protein defect reversible with natural vitamin A?  Medical Hypotheses.  54(6):979-983, 2000.
• Meisel, P., et al. Magnesium Deficiency is Associated with Periodontal Disease. Journal of Dental Research. 84(10): 937-941, 2005.
• Methylcobalamin. Alternative Medicine Review. 3:461-3, 1998.
• Meydani M.  Protective role of dietary vitamin E on oxidative stress in ageing.  Age.  15:89-93, 1992.
• Misner, D., et al. Vitamin A Deprivation Results in Reversible Loss of Hippocampal Long-term Synaptic Plasticity. Proceedings of the National Academy of Sciences. 98(20): 11714-11719, 2001.
• Moretti P et al. Cerebral folate deficiency with developmental delay, autism, and response to folinic acid. Neurology. 64(6):1088-90, 2005.
• Mousain-Bosc M et al. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. Magnesium Research. 19(1):53-62, 2006.
• Mousain-Bosc, M., et al. Magnesium, Vitamin B6 Intake Reduces Central Nervous System Hyperexcitability in Children. Journal of the American College of Nutrition.  23: 545S-548S, 2004.
• Nanci, A., et al. Morphological and Immunocytochemical Analyses on the Effects of Diet-induced Hypocalcemia on Enamel Maturation in the Rat Incisor.  Journal of Histochemistry and Cytochemistry. 48(8): 1043-1057, 2000.
• Numakawa Y et al.  Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.  Journal of Neurochemistry.  97(4):1191-1202, 2006.
• Osendarp S et al. Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia. American Journal of Clinical Nutrition. 86(4):1082-93, 2007.
• Outila, T., et al.  Vitamin D Status Affects Serum Parathyroid Hormone Concentrations during Winter in Female Adolescents: Associations with Forearm Bone Mineral Density.  American Journal of Clinical Nutrition. 74: 206 – 210, 2001.
• Paleologos M et al. Cohort Study of Vitamin C Intake and Cognitive Impairment. American Journal of Epidemiology. 148(1):45-50, 1998.
• Pfeiffer S et al. Efficacy of vitamin B6 and magnesium in the treatment of autism: a methodology review and summary of outcomes. Journal of Autism and Developmental Disorders. 25(5):481-93, 1995.
• Pussinen, P., et al. Periodontitis Is Associated with a Low Concentration of Vitamin C in Plasma. Clinical and Vaccine Immunology. 10(5): 897 – 902, 2003.
• Qing Shi, H., et al.  Host Nutritional Selenium Status as a Driving Force for Influenza Virus Mutations. The Federation of American Societies for Experimental Biology. Express Article published online, 2001.
• Rahman, J., et al. Effects of Zinc Supplementation as Adjunct Therapy on the Systemic Immune Responses in Shigellosis. American Journal of Clinical Nutrition. 81:  495 – 502, 2005.
• Raslova K., et al.  Effect of Diet and 677 C-->T 5, 10-Methylenetetrahydrofolate Reductase Genotypes on Plasma Homocyst(e)ine Concentrations in Slovak Adolescent Population. Physiological Research. 49(6): 651-8, 2000.
• Riggs, K. M., et al.  Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study.  American Journal of Clinical Nutrition.  63(3):306-314, 1996.
• Rimland B et al. The effect of high doses of vitamin B6 on autistic children:  a double-blind cross-over study.  American Journal of Psychiatry.  135(4):472, 1978.
• Rimland B. Controversies in the treatment of autistic children: vitamin and drug therapy. Journal of Child Neurology. 3 Suppl:S68-72, 1988.
• Rimland B. Vitamin B6 (and magnesium) in the treatment of autism.  Autism Research Review International.  1(4), 1987.
• Rimland B. Vitamin C in the Prevention and Treatment of Autism. Autism Research Review International. 12:3, 1998.
• Rink, L. and Kirchner, H.  Zinc-Altered Immune Function and Cytokine Production. Journal of Nutrition. 130: 1407S-1411S, 2000.
• Sasaki H et al.  Vitamin B12 improves cognitive disturbance in rodents fed a choline-deficient diet.  Pharmacology Biochemistry and Behavior.  43(2):635-639, 1992.
• Sasazuki, S., et al. Effect of Vitamin C on Common Cold: Randomized Controlled Trial.  European Journal of Clinical Nutrition.  60: 9-17, 2006.
• Sedgh, G., et al. Dietary Vitamin A Intake and Nondietary Factors Are Associated with Reversal of Stunting in Children. Journal of Nutrition. 130: 2520-2526, 2000.
• Slyshenkov V et al.  Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics.  FEBS Lett.  569(1-3):169-172, 2004.
• Taylor, A, et al. Rat Intestinal Vitamin D-dependent Calcium-binding Protein: Immunocytochemical Localization in Incisor Ameloblasts.  Journal of Dental Research.  63(2): 94-96, 1984.
• Thiamine - Monograph.  Alternative Medicine Review.  8(1):59-62, 2003.
• Tylavsky, F., et al. Fruit and Vegetable Intakes are an Independent Predictor of Bone Size in Early Pubertal Children. American Journal of Clinical Nutrition. 79: 311 – 317, 2004.
• Uauy, R., et al. Essentiality of Copper in Humans. American Journal of Clinical Nutrition. 67:  952 – 959, 1998.
• Udomkesmalee, E., et al. Effect of Vitamin A and Zinc Supplementation on the Nutriture of Children in Northeast Thailand. American Journal of Clinical Nutrition. 56: 50 – 57, 1992.
• Valero, M., et al. Vitamin C Is Associated with Reduced Risk of Cataract in a Mediterranean Population. Journal of Nutrition. 132: 1299-1306, 2002.
• Van Stuijvenberg, E., et al. Effect of Iron-, Iodine-, and ß-carotene–Fortified Biscuits on the Micronutrient Status of Primary School Children: a Randomized Controlled Trial. American Journal of Clinical Nutrition. 69:  497 – 503, 1999.
• Vatanparast, H., et al.  Positive Effects of Vegetable and Fruit Consumption and Calcium Intake on Bone Mineral Accrual in Boys during Growth from Childhood to Adolescence: the University of Saskatchewan Pediatric Bone Mineral Accrual Study.  American Journal of Clinical Nutrition.  82: 700-706, 2005.
• Villamor, E. and Fawzi, W. Effects of Vitamin A Supplementation on Immune Response and Correlation with Clinical Outcomes. Clinical Microbiology Reviews. 18: 446-464, 2005.
• Vitamin B6 (pyridoxine and pyridoxal 5'-phosphate) - monograph. Alternative Medicine Review. 6:87-92, 2001. Review.
• Werbach M.  Nutritional treatments for autism - nutritional influences on illness.  Townsend Letter for Doctors and Patients.  October 2003.
• Whiting, S., et al. Dietary Protein, Phosphorus and Potassium Are Beneficial to Bone Mineral Density in Adult Men Consuming Adequate Dietary Calcium. Journal of the American College of Nutrition.  21: 402-409, 2002.
• Yao Y et al. Altered vascular phenotype in autism: correlation with oxidative stress. Archives of Neurology. 63(8):1161-4, 2006.

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Understanding the Need for a Multivitamin

This product was designed to serve children in need of digestive, metabolic or neurological support. For many reasons, it is very important for such children to take a multivitamin. Children often have very particular tastes in food and are unlikely to eat a wide variety of items. It is crucial that children in need of digestive, metabolic or neurological support consume a specially formulated multivitamin.

What Makes Might-a-Mins^® Spectrum Isotonix^® Multivitamin Unique?

Might-a-Mins^® Spectrum Isotonix^® Multivitamin provides children with the vitamins and minerals they need for optimal health. Many children do not obtain the necessary amounts of vitamins and minerals due to high consumption of processed foods, poor nutrient absorption and exposure to environmental toxins. Might-a-Mins Spectrum Isotonix Multivitamin provides children in need of neurological, metabolic or digestive support with a strong micronutrient foundation which promotes healthy development and supports optimal immune functions.*

Might-a-Mins Spectrum Isotonix Multivitamin provides children in need of neurological, metabolic or digestive support with a carefully selected blend of vitamins and minerals chosen for their exceptional bioavailability. Ingredients such as folinic acid and P5P (pyridoxal 5 phosphate) are included as the forms of folic acid and vitamin B6, respectively, because they are the metabolically active forms of these vitamins. Another benefit of Might-a-Mins Spectrum Isotonix Multivitamin is that it is delivered in an isotonic solution. Isotonic solutions bear the same chemical resemblance to blood and tears, allowing for superior delivery and complete absorption.

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Frequently Asked Questions About Might-a-Mins^® Spectrum Isotonix^® Multivitamin:

Why an Isotonix® formula better than standard  children’s  multivitamin?

Isotonix formulas are more effective than standard children’s multivitamin formulas because they offer the best way to get the maximum delivery of vitamins and minerals into the bloodstream. Isotonix formulas are also the fastest and most effective way to receive multivitamins. The stomach has very little work to do because the pH and tonicity are carefully designed to allow the stomach to quickly release all the nutrients into the small intestine. With the Isotonix Might-A-Mins formula, this process takes about five minutes, where a standard vitamin tablet can take up to four hours.

Does Isotonix Might-A-Mins contain artificial ingredients?

Isotonix Might-A-Mins does not contain any artificial sweeteners, such as saccharin or aspartame. Like all other Isotonix products, there are also no artificial preservatives or colors.

Do kids like the taste of Isotonix Might-A-Mins?

Isotonix Might-A-Mins contains fructose and glucose, which are both naturally occurring sugars. The sugars are also blended with a delicious, natural Mandarin orange flavor. The vitamins come in a fun, fast and easy-to-prepare powder, which will make your kids look forward to taking their vitamins every day.

Why do children need to take a multivitamin?

Everyone needs vitamins and minerals, because they help release energy from our food and help build muscle, bone, blood and other vital tissue. Children need vitamins and minerals to maintain good health and normal growth. It is important to ensure that children receive all the vitamins and minerals they need every day, especially during their growing years. The body does not store all essential vitamins and minerals, therefore some need to be supplied on a regular basis through the use of a multivitamin.

Is there a specific time of day that is recommended for taking a multivitamin?

In general, any time of day is fine for taking a multivitamin. However it is good practice to take it at the same time each day to develop a routine.

What are common vitamins and minerals that kids don’t get enough of through their diets?

            Calcium, Zinc and vitamins A, C and E, are some common vitamins and minerals that children generally don’t get enough of through dietary intake. Calcium is needed to form growing bones and a proper calcium intake beginning at childhood can help maintain normal bone mass later in life. Zinc is a vital nutrient for proper growth and development. Vitamins A, C and E are also important vitamins during childhood and throughout life.

     Is it safe to take this with the other Might-a-Mins Spectrum products?

     Yes, these products complement each other and are safe and effective

     when taken together.

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Primary Benefits of Might-a-Mins® Spectrum Isotonix® Multivitamin*:

·         Helps promote normal levels of vitamins and minerals in individuals who need neurological, digestive or metabolic support

·         Helps maintain normal production of neurotransmitters

·         Promotes/supports a healthy nervous system

·         Helps maintain brain health

·         Promotes healthy sensory development

·         Provides strong antioxidant defense

·         Combats free radicals

·         Promotes normal tissue and cell growth

·         Provides nutrients essential for numerous body processes

·         Supports optimal immune functions

·         Supports skeletal health and growth

·         Supports healthy teeth and gums

·         Supports growth and strength of teeth and bones

·         Supports cognitive health and development

·         Supports healthy vision and eyes

·         Supports a healthy heart

Key Ingredients Found In Might-a-Mins^® Spectrum Isotonix^® Multivitamin:

Beta-Carotene: 3750 IU

Beta-carotene is a nutrient found in plants that the body converts into vitamin A. Vitamin A promotes normal cell growth and differentiation in the tissues of the gastrointestinal tract and brain. Children who need neurological, metabolic or digestive support may benefit from beta-carotene because of its ability to promote normal tissue and cell growth and promote healthy sensory development.* 

Vitamin B1 (Thiamin): 10 mg

Vitamin B1 is a water-soluble vitamin that promotes normal processing of carbohydrates, fat, and protein. Every cell of the body requires vitamin B1 to form the fuel the body runs on — adenosine triphosphate (ATP). Vitamin B1 promotes normal functioning of nerve cells and plays an important role in carbohydrate metabolism. B1 helps maintain a healthy nervous system by supporting the normal production of the neurotransmitters acetylcholine and gamma-aminobutyric acid (GABA).

Vitamin B2 (Riboflavin): 10 mg

Vitamin B2 is a water-soluble vitamin that promotes the normal processing of amino acids and fats, activation of vitamin B6 and folic acid, and supports the conversion of carbohydrates into the fuel the body runs on — adenosine triphosphate (ATP). It also promotes healthy red blood cell formation, supports the nervous system, respiration, antibody production and normal human growth.

Niacinamide: 20 mg

Niacin, also known as vitamin B3, supports energy production in the body. It works with vitamin B1 and vitamin B2 to support the release of energy from carbohydrates. Similar to vitamin B6 and folic acid, niacin supports many pathways which help renew the body’s tissues.

P5P (pyridoxal 5 phosphate): 37.5 mg

Pyridoxal-5-phosphate is the active form of vitamin B6. Vitamin B6 is the master vitamin for numerous metabolic pathways in the body. One specific function is that it supports the normal synthesis of neurotransmitters in the brain and peripheral nerve cells, which are critical for the development of language, attention and alertness. B6 also promotes the normal production of glutathione, which is essential for detoxification. P5P promotes healthy sensory development by supporting the normal synthesis of neurotransmitters in the brains of children who need neurological support.*

Pantothenic acid: 15 mg

Pantothenic acid, also called vitamin B5, is a water-soluble vitamin involved in energy production and the formation of the neurotransmitter acetylcholine, which is important for brain health. Pantothenic acid works together with vitamin B1, vitamin B2, and vitamin B3 to make the fuel our body runs on – ATP. It also promotes the normal production, transport, and release of energy from fats.

Vitamin B12 (Methylcobalamin): 10 mcg

Vitamin B12 is a water-soluble vitamin that supports normal nerve cell activity, DNA replication, and production of the mood-affecting substance SAMe (S-adenosyl-L-methionine). B12 promotes normal conversion of sulfur-containing compounds to glutathione, a powerful antioxidant in the body. B12 provides strong antioxidant defense and combats free radicals in children who need neurological, metabolic or digestive support.*

Folinic acid: 300 mcg

Folinic acid is the metabolically active form of folic acid. Folic acid is a B vitamin essential for numerous processes in the body and supports normal development of the nervous system. Additionally, folic acid supports the conversion of sulfur-containing compounds to glutathione. Children who need neurological support can benefit from folic acid’s ability to help maintain the normal production of neurotransmitters and promotes a healthy nervous system.*

Biotin: 150 mcg

Biotin, a water-soluble B vitamin, acts as a coenzyme in the metabolism of protein, fats, and carbohydrates. Biotin also supports various metabolic chemical conversions. Children get the energy they need from food through metabolism, the chemical reactions in the body's cells that convert the fuel from food into the energy needed to do everything from moving to thinking to growing.

Vitamin C: 300 mg

Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that has a number of biological functions. It supports normal tissue repair, healing and immune function. It is also a cofactor for dopamine production. Supplementing with a proven antioxidant, like vitamin C, is helpful in combating free radicals, especially in children who need neurological, metabolic or digestive support. Vitamin C supports glutathione levels, another important antioxidant in the body. Vitamin C’s strong antioxidant protection can support optimal immune function in children who need neurological, metabolic or digestive support.* 

Vitamin D3 (Cholecalciferol): 200 IU

Vitamin D, a powerful antioxidant, promotes proper brain development. It is also helpful promoting normal glutathione levels which assist in detoxification of the body. In addition to supporting strong bone, vitamin D promotes muscle strength and neuromuscular function. The main function of vitamin D is to support normal regulation of serum calcium concentrations. Children who need neurological, metabolic or digestive support have growing bodies that can benefit from Vitamin D3 because it promotes calcium absorption and retention, supports growth and strength of teeth and bones, and supports skeletal health and growth.*

Vitamin E (D-alpha-tocopheryl acetate): 33 IU

Vitamin E is a fat-soluble vitamin proven to be a strong antioxidant. It supports the structural and functional maintenance of skeletal, cardiac and smooth muscle. It also promotes normal formation of red blood cells, supports cardiovascular function and promotes immune health.

Calcium (Carbonate): 100 mg

Calcium is an important mineral which supports numerous body processes including bone development and maintenance, nerve transmission, muscle contraction, vascular contraction, vasodilation, glandular secretion, cell membrane and capillary permeability, enzymatic reactions, respiration, renal function, and blood coagulation. Children who need neurological, metabolic or digestive support have growing bodies that can benefit from calcium because it supports growth and strength of teeth and bones, skeletal health and growth, and healthy teeth and gums.*

Chromium (Amino Acid Chelate): 25 mcg – Chromium is an essential trace mineral that helps maintain normal glucose metabolism and helps maintain normal insulin and serum cholesterol levels. Chromium combines to form glucose tolerance factor or GTF in the body, which supports the actions of insulin in helping to maintain healthy blood sugar levels.

Iodine: 50 mcg

The trace element is also present in more than a hundred enzyme systems such as energy production, nerve function and hair and skin growth. One of iodine’s main functions includes supporting the thyroid gland in producing thyroid hormones thyroxin and tri-iodothyronine, which support the regulation of metabolic rate.

Magnesium (Lactate): 200 mg

Magnesium, an essential mineral, promotes normal function of over 300 enzymes, specifically those enzymes responsible for the production of neurotransmitters in the brain. Magnesium supports a number of other metabolic pathways including bone, protein and fatty acid formation, B vitamin activation, muscle relaxation, blood clotting and formation of adenosine triphosphate. Children who need neurological, metabolic or digestive support have growing bodies that can benefit from magnesium. Not only does it support bone formation, it promotes normal production of neurotransmitters.*

Manganese (Sulfate): 1 mg

Manganese supports normal formation of connective tissue, bones, and blood-clotting factors. It supports fat and carbohydrate metabolism, calcium absorption, and blood sugar regulation. Manganese also promotes normal brain and nerve function. Manganese may promote the normal use of nutrients including biotin, thiamin, ascorbic acid, and choline.

Selenium (Selenomethionine): 55 mcg

In the body, selenium functions as part of an antioxidant enzyme called glutathione peroxidase, as well as supporting normal growth and proper usage of iodine in thyroid functioning. Selenium also supports the antioxidant effect of vitamin E.

Zinc (Sulfate): 15 mg

Zinc is an essential mineral that is a cofactor in nearly 100 enzymes. It supports healing, protein synthesis, brain maintenance and development, cell reproduction, vision, immunity, and protects against free radicals in children who need neurological, metabolic or and digestive support.*

Scientific Studies Which Support Might-a-Mins^® Spectrum Isotonix^® Multivitamin:

• Adams J et al.  Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder.  Journal of Alternative and Complementary Medicine.  10(6):1033-1039, 2004.
• Adams J et al. Analyses of toxic metals and essential minerals in the hair of Arizona children with autism and associated conditions, and their mothers. Biology Trace Element Research. 110(3):193-209, 2006.
• Adams J. Summary of Biomedical Treatments for Autism. Autism Research Institute Publication. 40 (April), 2007.
• Ah Kang-Yoon S et al.  Relation of short-term pyridoxine-hydrochloride supplementation to plasma vitamin-B6 vitamers and amino acid concentrations in young women.  American Journal of Clinical Nutrition.  55(4):865-872, 1992.
• Ahmed, F., et al. Efficacy of Twice-Weekly Multiple Micronutrient Supplementation for Improving the Hemoglobin and Micronutrient Status of Anemic Adolescent Schoolgirls in Bangladesh. American Journal of Clinical Nutrition. 82:  829 – 835, 2005.
• Alarcon, K., et al. Effects of Separate Delivery of Zinc or Zinc and Vitamin A on Hemoglobin Response, Growth, and Diarrhea in Young Peruvian Children Receiving Iron Therapy for Anemia.  American Journal of Clinical Nutrition. 80: 1276 – 1282, 2004.
• Angley M et al. Children and autism--Part 2--management with complementary medicines and dietary interventions. Australian Family Physician. 36(10):827-30, 2007.
• Anonymous. Vitamin B6 (pyridoxine and pyridoxal 5'-phosphate) - monograph. Alternative Medicine Review. 6(1):87-92, 2001. Review.
• Audhya T. (2002, October).  Laboratory indices of vitamin and mineral deficiency in autism.  Paper presented at the Defeat Autism Now! Conference, San Diego, California.
• Autism Research Institute. http://www.autism.com/ari/. Accessed May and June 2008.
• Baez-Saldana A et al.  Biotin deficiency induces changes in subpopulations of spleen lymphocytes in mice.  American Journal of Clinical Nutrition.  67(3):431-437, 1998.
• Balogh, K., et al. Inhibition of Bacterial Growth in Human Saliva by Vitamins B1, B2, and B6. Journal of Dental Research. 36 (5): 886-891, 1960.
• Baqui, A., et al. Simultaneous Weekly Supplementation of Iron and Zinc Is Associated with Lower Morbidity Due to Diarrhea and Acute Lower Respiratory Infection in Bangladeshi Infants. Journal of Nutrition. 133: 4150-4157, 2003.
• Benton, D., et al.  Thiamine supplementation mood and cognitive functioning.  Psychopharmacology (Berlin).  129(1):66-71, 1997.
• Bhandari, N., et al. Effect of Routine Zinc Supplementation on Pneumonia in Children Aged 6 Months to 3 Years: Randomized Controlled Trial in an Urban Slum. British Medical Journal. 324: 1358-1362, 2002.
• Bhandari, N., et al. Substantial Reduction in Severe Diarrheal Morbidity by Daily Zinc Supplementation in Young North Indian Children.  Pediatrics.  109: 86-92, 2002.
• Black, M., et al. Iron and Zinc Supplementation Promote Motor Development and Exploratory Behavior Among Bangladeshi Infants. American Journal of Clinical Nutrition. 80: 903 – 910, 2004.
• Brouwer, I., et al. Dietary Folate from Vegetables and Citrus Fruit Decreases Plasma Homocysteine Concentrations in Humans in a Dietary Controlled Trial.  Journal of Nutrition. 129: 1135-1139, 1999.
• Bryan, J., et al. Short-Term Folate, Vitamin B-12 or Vitamin B-6 Supplementation Slightly Affects Memory Performance But Not Mood in Women of Various Ages. Journal of Nutrition. 132: 1345-1356, 2002.
• Burton G et al.  Vitamin E:  Antioxidant activity, biokinetics, and bioavailability.  Annual Review Nutrition.  10:357-382, 1992.
• Carter, l., et al. Self-Reported Calcium Intake and Bone Mineral Content in Children and Adolescents. Journal of the American College of Nutrition.  20: 502-509, 2001. 
• Chitchumroonchokchai, C., et al. Xanthophylls and  -Tocopherol Decrease UVB-Induced Lipid Peroxidation and Stress Signaling in Human Lens Epithelial Cells. Journal of Nutrition. 134: 3225-3232, 2004.
• Clark J et al. Symptomatic vitamin A and D deficiencies in an eight-year-old with autism. JPEN Journal of Parenteral and Enteral Nutrition. 17:284-6. 1993.
• DeAnn J et al.  Gut restoration and chronic disease.  Journal of the American Nutraceutical Association.  5(4):20-33, 2002.
• Dietrich, T., et al. Association between Serum Concentrations of 25-Hydroxyvitamin D and Gingival Inflammation. American Journal of Clinical Nutrition. 82: 575 – 580, 2005.
• Diliberto E et al. Multicompartmental secretion of ascorbate and its dual role in dopamine b-hydroxylation.  American Journal of Clinical Nutrition.  54(6 Supplement):1163S-72S, 1991.
• Dodiuk-Gad, R. P., et al. Sustained Effect of Short-term Calcium Supplementation on Bone Mass in Adolescent Girls with Low Calcium Intake. American Journal of Clinical Nutrition. 81: 168 – 174, 2005.
• Dolske M. et al.  A preliminary trial of ascorbic acid as supplemental therapy for autism.  Progress in Neuropsycho-pharmacology and Biological Psychiatry.  17(2):765-774, 1993.
• Earnest, C., et al. Complex Multivitamin Supplementation Improves Homocysteine and Resistance to LDL-C Oxidation. Journal of the American College of Nutrition. 22: 400-407, 2003.
• Engler, M. M., et al. Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation. 108: 1059 – 1063, 2003.
• Etten, E., et al. 1,25-Dihydroxycholecalciferol: Endocrinology Meets the Immune System.  Proceedings of the Nutrition Society.  61: 375-380, 2002.
• Fernandez-Robredo, P., et al. Vitamins C and E Reduce Retinal Oxidative Stress and Nitric Oxide Metabolites and Prevent Ultrastructural Alterations in Porcine Hyperscholesterolemia. Investigative Ophthalmology and Visual Science. 46 (4): 1140-1146, 2005.
• Frei B et al. Ascorbate is an outstanding antioxidant in human blood plasma.  Proceedings of the National Academy of Sciences USA.  86(16):6377-6381, 1989.
• Gardner, J., et al. Zinc Supplementation and Psychosocial Stimulation: Effects on the Development of Undernourished Jamaican Children. American Journal of Clinical Nutrition. 82: 399 – 405, 2005.
• Hall, S. and Greendale, G.  The Relation of Dietary Vitamin C Intake to Bone Mineral Density: Results from the PEPI Study.  Calcified Tissue International. 63: 183-189, 1998.
• Halterman, J., et al. Iron Deficiency and Cognitive Achievement among School-Aged Children and Adolescents in the United States. Pediatrics. 107: 1381 – 1386, 2001.
• Henning S et al.  Glutathione blood levels and other oxidant defense indexes in men fed diets low in vitamin C.  Journal of Nutrition.  121:169-175, 1991.
• Holick, M. Resurrection of Vitamin D Deficiency and Rickets. Journal of Clinical Investigation. 116: 2062-2072, 2006.
• Holick, M. Vitamin D: Importance in the Prevention of Cancers, Type 1 Diabetes, Heart Disease, and Osteoporosis. American Journal of Clinical Nutrition. 79: 362 – 371, 2004.
• James S et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. American Journal of Clinical Nutrition. 80(6):1611-7, 2004.
• Johnston C et al. Vitamin C elevates red blood cell glutathione in healthy adults.  American Journal of Clinical Nutrition.  58(1):103-105, 1993.
• Kelly G. Folates: supplemental forms and therapeutic applications. Alternative Medicine Review. 3:208-20, 1998. Review.
• Kidd P. Autism, an extreme challenge to integrative medicine.  Part II: medical management. Alternative Medicine Review. 7(6):472-499, 2002.
• Kimura,  M., et al.  Methylenetetrahydrofolate Reductase C677T Polymorphism, Folic Acid and Riboflavin are Important Determinants of Genome Stability in Cultured Human Lymphocytes. Journal of  Nutrition. 134(1):48-56, 2004.
• Kirsch M et al. Ascorbate is a potent antioxidant against peroxynitrite-induced oxidation reactions. Evidence that ascorbate acts by re-reducing substrate radicals produced by peroxynitrite.  J Biol Chem.  275(22):16702-16708, 2000.
• Kleijnen J and Knipschild P. Niacin and vitamin B6 in mental functioning: a review of controlled trials in humans. Biological Psychiatry. 29(9):931-41, 1991.
• Kotsanis C et al. Autism – A multidisciplinary approach to treatment. Study Profile, DFW Ear, Nose & Throat Associates. Grapevine TX. No date given.
• Kraus, A., et al. Supplementation with Vitamin C, Vitamin E or ß-Carotene Influences Osmotic Fragility and Oxidative Damage of Erythrocytes of Zinc-Deficient Rats. Journal of Nutrition. 127: 1290-1296, 1997.
• Kuo C et al.  Ascorbic acid, an endogenous factor required for acetylcholine release from the synaptic vesicles.  Japan Journal of Pharmacology.  30(4):481-492, 1980.
• Leggott, P., et al. Effects of Ascorbic Acid Depletion and Supplementation on Periodontal Health and Subgingival Microflora in Humans. Journal of Dental Research. 70: 1531-1536, 1991.
• Lelord G et al.  Effects of pyridoxine and magnesium on autistic symptoms:  initial observations.  Journal of Autism Developmental Disorders.  11(2):219-229, 1981.
• Lenton, Kevin J., et al.  Vitamin C Augments Lymphocyte Glutathione in Subjects with Ascorbate Deficiency. American Journal of Clinical Nutrition. 77: 189 – 195, 2003.
• Levy A and Hyman S. Use of complementary and alternative treatments for children with autistic spectrum disorders is increasing. Pediatric Annals. 32:685-91, 2003.
• Levy S et al. Novel treatments for autistic spectrum disorders. Mental Retardation and Developmental Disabilities Research Reviews. 11(2):131-42, 2005. Review.
• LimeBack, H., et al.  The effects of Hypocalcemia/Hypophosphatemia on Porcine Bone and Dental Hard tissues in an Inherited Form of Type 1 Pseudo-Vitamin D Deficiency Rickets. Journal of Dental Research. 71:346-352, 1992.
• Lonsdale D et al. Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: A pilot study.  Neuroendocrinology Letters.  23(4):303-308, 2002.
• Marlow M et al.  Decreased magnesium in the hair of autistic children.  Journal of Orthomolecular Psychiatry.  13(2):117-122, 1984.
• Martineau J et al.  Vitamin B6, magnesium, and combined B6-Mg:  therapeutic effects in childhood autism.  Biological Psychiatry.  20(5):467-478, 1985.
• Martineau J et al. Brief report: an open middle-term study of combined vitamin B6-magnesium in a subgroup of autistic children selected on their sensitivity to this treatment.  Journal of Autism and Developmental Disorders. 18:435-447, 1988.
• Martineau J et al. Effects of vitamin B6 on averaged evoked potential in infantile autism.  Biological Psychiatry.  16(7):627-641, 1981.
• Martineau J et al. Electrophysiological effects of fenfluramine or combined vitamin B6 and magnesium on children with autistic behavior. Developmental Medicine and Child Neurology. 31:728-736, 1989.
• Matkovic, V., et al.  Calcium Supplementation and Bone Mineral Density in Females from Childhood to Young Adulthood: A Randomized Controlled Trial. American Journal of Clinical Nutrition. 81: 175 – 188, 2005.
• Matsuda, T. and Toda, T. Effects of Vitamin B6 on Dental Caries in Rats.  Journal of Dental Research.  46(6): 1460-1464, 1967.
• McGinnis W. Oxidative stress in autism. Alternative Therapies in Health and Medicine. 10(6):22-36, 2004. Review.
• Megson M. Is autism a G-alpha protein defect reversible with natural vitamin A?  Medical Hypotheses.  54(6):979-983, 2000.
• Meisel, P., et al. Magnesium Deficiency is Associated with Periodontal Disease. Journal of Dental Research. 84(10): 937-941, 2005.
• Methylcobalamin. Alternative Medicine Review. 3:461-3, 1998.
• Meydani M.  Protective role of dietary vitamin E on oxidative stress in ageing.  Age.  15:89-93, 1992.
• Misner, D., et al. Vitamin A Deprivation Results in Reversible Loss of Hippocampal Long-term Synaptic Plasticity. Proceedings of the National Academy of Sciences. 98(20): 11714-11719, 2001.
• Moretti P et al. Cerebral folate deficiency with developmental delay, autism, and response to folinic acid. Neurology. 64(6):1088-90, 2005.
• Mousain-Bosc M et al. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. Magnesium Research. 19(1):53-62, 2006.
• Mousain-Bosc, M., et al. Magnesium, Vitamin B6 Intake Reduces Central Nervous System Hyperexcitability in Children. Journal of the American College of Nutrition.  23: 545S-548S, 2004.
• Nanci, A., et al. Morphological and Immunocytochemical Analyses on the Effects of Diet-induced Hypocalcemia on Enamel Maturation in the Rat Incisor.  Journal of Histochemistry and Cytochemistry. 48(8): 1043-1057, 2000.
• Numakawa Y et al.  Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.  Journal of Neurochemistry.  97(4):1191-1202, 2006.
• Osendarp S et al. Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia. American Journal of Clinical Nutrition. 86(4):1082-93, 2007.
• Outila, T., et al.  Vitamin D Status Affects Serum Parathyroid Hormone Concentrations during Winter in Female Adolescents: Associations with Forearm Bone Mineral Density.  American Journal of Clinical Nutrition. 74: 206 – 210, 2001.
• Paleologos M et al. Cohort Study of Vitamin C Intake and Cognitive Impairment. American Journal of Epidemiology. 148(1):45-50, 1998.
• Pfeiffer S et al. Efficacy of vitamin B6 and magnesium in the treatment of autism: a methodology review and summary of outcomes. Journal of Autism and Developmental Disorders. 25(5):481-93, 1995.
• Pussinen, P., et al. Periodontitis Is Associated with a Low Concentration of Vitamin C in Plasma. Clinical and Vaccine Immunology. 10(5): 897 – 902, 2003.
• Qing Shi, H., et al.  Host Nutritional Selenium Status as a Driving Force for Influenza Virus Mutations. The Federation of American Societies for Experimental Biology. Express Article published online, 2001.
• Rahman, J., et al. Effects of Zinc Supplementation as Adjunct Therapy on the Systemic Immune Responses in Shigellosis. American Journal of Clinical Nutrition. 81:  495 – 502, 2005.
• Raslova K., et al.  Effect of Diet and 677 C-->T 5, 10-Methylenetetrahydrofolate Reductase Genotypes on Plasma Homocyst(e)ine Concentrations in Slovak Adolescent Population. Physiological Research. 49(6): 651-8, 2000.
• Riggs, K. M., et al.  Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study.  American Journal of Clinical Nutrition.  63(3):306-314, 1996.
• Rimland B et al. The effect of high doses of vitamin B6 on autistic children:  a double-blind cross-over study.  American Journal of Psychiatry.  135(4):472, 1978.
• Rimland B. Controversies in the treatment of autistic children: vitamin and drug therapy. Journal of Child Neurology. 3 Suppl:S68-72, 1988.
• Rimland B. Vitamin B6 (and magnesium) in the treatment of autism.  Autism Research Review International.  1(4), 1987.
• Rimland B. Vitamin C in the Prevention and Treatment of Autism. Autism Research Review International. 12:3, 1998.
• Rink, L. and Kirchner, H.  Zinc-Altered Immune Function and Cytokine Production. Journal of Nutrition. 130: 1407S-1411S, 2000.
• Sasaki H et al.  Vitamin B12 improves cognitive disturbance in rodents fed a choline-deficient diet.  Pharmacology Biochemistry and Behavior.  43(2):635-639, 1992.
• Sasazuki, S., et al. Effect of Vitamin C on Common Cold: Randomized Controlled Trial.  European Journal of Clinical Nutrition.  60: 9-17, 2006.
• Sedgh, G., et al. Dietary Vitamin A Intake and Nondietary Factors Are Associated with Reversal of Stunting in Children. Journal of Nutrition. 130: 2520-2526, 2000.
• Slyshenkov V et al.  Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics.  FEBS Lett.  569(1-3):169-172, 2004.
• Taylor, A, et al. Rat Intestinal Vitamin D-dependent Calcium-binding Protein: Immunocytochemical Localization in Incisor Ameloblasts.  Journal of Dental Research.  63(2): 94-96, 1984.
• Thiamine - Monograph.  Alternative Medicine Review.  8(1):59-62, 2003.
• Tylavsky, F., et al. Fruit and Vegetable Intakes are an Independent Predictor of Bone Size in Early Pubertal Children. American Journal of Clinical Nutrition. 79: 311 – 317, 2004.
• Uauy, R., et al. Essentiality of Copper in Humans. American Journal of Clinical Nutrition. 67:  952 – 959, 1998.
• Udomkesmalee, E., et al. Effect of Vitamin A and Zinc Supplementation on the Nutriture of Children in Northeast Thailand. American Journal of Clinical Nutrition. 56: 50 – 57, 1992.
• Valero, M., et al. Vitamin C Is Associated with Reduced Risk of Cataract in a Mediterranean Population. Journal of Nutrition. 132: 1299-1306, 2002.
• Van Stuijvenberg, E., et al. Effect of Iron-, Iodine-, and ß-carotene–Fortified Biscuits on the Micronutrient Status of Primary School Children: a Randomized Controlled Trial. American Journal of Clinical Nutrition. 69:  497 – 503, 1999.
• Vatanparast, H., et al.  Positive Effects of Vegetable and Fruit Consumption and Calcium Intake on Bone Mineral Accrual in Boys during Growth from Childhood to Adolescence: the University of Saskatchewan Pediatric Bone Mineral Accrual Study.  American Journal of Clinical Nutrition.  82: 700-706, 2005.
• Villamor, E. and Fawzi, W. Effects of Vitamin A Supplementation on Immune Response and Correlation with Clinical Outcomes. Clinical Microbiology Reviews. 18: 446-464, 2005.
• Vitamin B6 (pyridoxine and pyridoxal 5'-phosphate) - monograph. Alternative Medicine Review. 6:87-92, 2001. Review.
• Werbach M.  Nutritional treatments for autism - nutritional influences on illness.  Townsend Letter for Doctors and Patients.  October 2003.
• Whiting, S., et al. Dietary Protein, Phosphorus and Potassium Are Beneficial to Bone Mineral Density in Adult Men Consuming Adequate Dietary Calcium. Journal of the American College of Nutrition.  21: 402-409, 2002.
• Yao Y et al. Altered vascular phenotype in autism: correlation with oxidative stress. Archives of Neurology. 63(8):1161-4, 2006.

Understanding the Need for a Multivitamin

This product was designed to serve children in need of digestive, metabolic or neurological support. For many reasons, it is very important for such children to take a multivitamin. Children often have very particular tastes in food and are unlikely to eat a wide variety of items. It is crucial that children in need of digestive, metabolic or neurological support consume a specially formulated multivitamin.

What Makes Might-a-Mins^® Spectrum Isotonix^® Multivitamin Unique?

Might-a-Mins^® Spectrum Isotonix^® Multivitamin provides children with the vitamins and minerals they need for optimal health. Many children do not obtain the necessary amounts of vitamins and minerals due to high consumption of processed foods, poor nutrient absorption and exposure to environmental toxins. Might-a-Mins Spectrum Isotonix Multivitamin provides children in need of neurological, metabolic or digestive support with a strong micronutrient foundation which promotes healthy development and supports optimal immune functions.*

Might-a-Mins Spectrum Isotonix Multivitamin provides children in need of neurological, metabolic or digestive support with a carefully selected blend of vitamins and minerals chosen for their exceptional bioavailability. Ingredients such as folinic acid and P5P (pyridoxal 5 phosphate) are included as the forms of folic acid and vitamin B6, respectively, because they are the metabolically active forms of these vitamins. Another benefit of Might-a-Mins Spectrum Isotonix Multivitamin is that it is delivered in an isotonic solution. Isotonic solutions bear the same chemical resemblance to blood and tears, allowing for superior delivery and complete absorption.

Frequently Asked Questions About Might-a-Mins^® Spectrum Isotonix^® Multivitamin:

Why an Isotonix® formula better than standard  children’s  multivitamin?

Isotonix formulas are more effective than standard children’s multivitamin formulas because they offer the best way to get the maximum delivery of vitamins and minerals into the bloodstream. Isotonix formulas are also the fastest and most effective way to receive multivitamins. The stomach has very little work to do because the pH and tonicity are carefully designed to allow the stomach to quickly release all the nutrients into the small intestine. With the Isotonix Might-A-Mins formula, this process takes about five minutes, where a standard vitamin tablet can take up to four hours.

Does Isotonix Might-A-Mins contain artificial ingredients?

Isotonix Might-A-Mins does not contain any artificial sweeteners, such as saccharin or aspartame. Like all other Isotonix products, there are also no artificial preservatives or colors.

Do kids like the taste of Isotonix Might-A-Mins?

Isotonix Might-A-Mins contains fructose and glucose, which are both naturally occurring sugars. The sugars are also blended with a delicious, natural Mandarin orange flavor. The vitamins come in a fun, fast and easy-to-prepare powder, which will make your kids look forward to taking their vitamins every day.

Why do children need to take a multivitamin?

Everyone needs vitamins and minerals, because they help release energy from our food and help build muscle, bone, blood and other vital tissue. Children need vitamins and minerals to maintain good health and normal growth. It is important to ensure that children receive all the vitamins and minerals they need every day, especially during their growing years. The body does not store all essential vitamins and minerals, therefore some need to be supplied on a regular basis through the use of a multivitamin.

Is there a specific time of day that is recommended for taking a multivitamin?

In general, any time of day is fine for taking a multivitamin. However it is good practice to take it at the same time each day to develop a routine.

What are common vitamins and minerals that kids don’t get enough of through their diets?

            Calcium, Zinc and vitamins A, C and E, are some common vitamins and minerals that children generally don’t get enough of through dietary intake. Calcium is needed to form growing bones and a proper calcium intake beginning at childhood can help maintain normal bone mass later in life. Zinc is a vital nutrient for proper growth and development. Vitamins A, C and E are also important vitamins during childhood and throughout life.

     Is it safe to take this with the other Might-a-Mins Spectrum products?

     Yes, these products complement each other and are safe and effective

     when taken together.

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.