Heart Health™ Chewable CoQ10

Primary Benefits of Heart Health™ Chewable CoQ10*:

·        Enhances support of cardiovascular health

·        Helps maintain healthy blood sugar levels

·        Helps maintain heart muscle strength

·        Helps maintain normal blood pressure

·        Promotes/boosts the immune system

·        Promotes cardiovascular health

·        Promotes gum health

·        Promotes head comfort

·        Helps maintain healthy cholesterol levels

·        Provides antioxidant protection for the cardiovascular system

·        Supports/helps maintain brain health

·        Vital for ATP production and supports muscle endurance

Key Ingredients Found In Heart Health™ Chewable CoQ10:

Natural Coenzyme Q10: 100 mg

Coenzyme Q10 belongs to a family of substances called ubiquinones, and is a water-insoluble, wax-like substance that is part of the respiratory chain. Since it is a coenzyme, it is necessary to support the action of an enzyme, and it has a similar structure to vitamin K. CoQ10 is found in each of the 50-75 trillion cells throughout the body, except for mature red blood cells. It has a multitude of health benefits at the cellular level, in the cardiovascular system, and in metabolic processes. It serves to revitalize and energize the body’s cells and immune system and contributes to increases in stamina and endurance by fueling the body’s energy production (ATP) cycle. It is beneficial to the cardiovascular system because it helps to protect the heart, helps maintain normal blood pressure, and promotes mental alertness and normal brain activity.*

The mechanism of action of supplemental coenzyme Q10 has yet to be clarified, and is a matter of much speculation. However, much is known about the biochemistry of CoQ10. Coenzyme Q10 is a two-part compound that is composed of a long, fat-soluble isoprenoid tail that anchors the molecule in the inner membrane of the mitochondria, and quinine that is capable of accepting and transferring electrons through a portion of the respiratory chain. The “Q” stands for quinine and the “10” stands for the number of isoprenoid units in the tail portion of the molecule. It is synthesized in the cells, and is involved in electron transport and energy production in mitochondria. In the cellular system, it functions to generate energy from oxygen, in the form of ATP, for bodily processes. It serves as a free-radical scavenger and an antioxidant. The antioxidant activity in the mitochondria and cell membranes promotes the stability and health of lipid membranes.*

Heart Health™ Chewable CoQ10 supplies naturally fermented coenzyme Q10 in a great tasting, natural citrus-flavored chewable tablet.  It is formulated using patented fast melt technology designed to allow the tablet to begin dissolving immediately upon contact with saliva.  As the tablet melts the liquid is swallowed and it’s rapidly delivered into the blood stream so that your cardiovascular system, immune system, and more importantly, your body receives the great benefits of CoQ10.*

Scientific Studies Which Support Heart Health™ Chewable CoQ10:

·         Kagan, V, et al.  Coenzyme Q: Its role in scavenging and generation of radicals in membranes.  In Handbook of Antioxidants, eds.  Enrique Cadenas and Lester Packer, New York, Marcel Dekker, Inc., 1996, pp. 157-201.

·         Littarru, G.P. et al.  Clinical aspects of coenzyme Q: Improvement of cellular bioenergetics or antioxidant protection?  In Handbook of Antioxidants, eds. E. Cadenas and L. Packer: New York, Marcel Dekker, Inc., 1996, pp. 203-239.

·         Greenberg, S. and Frishman, W.H.  Coenzyme Q10: A new drug for cardiovascular disease.  Journal of Clinical Pharmacology 30: 596-608, 1990.

·         Chello, M, et al.  Protection of coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting.  Annals of Thoracic Surgery 58: 1427-1432, 1994.

·         Lansjoen, P.H. et al.  Response of patients in classes III and IV of cardiomyopathy to therapy in a blind crossover trial with coenzyme Q10.  Proceedings of the National Academy of Sciences USA 82: 4240, 1985.

·         Stryer, L. Biochemistry, 2nd ed. New York, W.H. Freeman and Company, 1981.

·         Firstein, R. The Nutraceutical Revolution. New York, Riverhead Books, 1998.

·         Frei, B, et al. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.  Proceedings of the National Academy of Sciences USA 87: 4879-4883, 1990.

·         Hanaki, Y. et al. Ratio of low-density lipoprotein cholesterol to ubiquinone as a coronary risk factor: New England Journal of Medicine, 325: 814-815, 1991.

·         Singh R.B. and Singh M.M.  Effects of coenzyme Q10 in new indications with antioxidant vitamin deficiency. Journal of Nutritional and Environmental Medicine 9: 223-228, 1999.

·         Greenburg S. and Frishman W. Coenzyme Q10: A new drug from myocardial ischemia? Medical Clinics of North America 72: 243-58, 1998.

·         Langsjoen, P.H. et al.  Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy.  International Journal of Tissue Reactions 12: 163-168, 1990.

·         Digiesi, V. et al. Mechanism of action of coenzyme Q10 in essential hypertension.  Current Therapy and Research 51: 668-672, 1992.

·         Sunamori, M. et al. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovascular Drugs and Therapy 5: 297-300, 1991.

·         Langsjoen, P.H. et al. A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10.  International Journal of Tissue Reactions 12: 169-71, 199.

·         Stocker, R. et al. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proceedings of the National Academy of Sciences USA 88: 1646-1650, 1991.

·         Shi, H. and Noguchi, N.  Dynamics of antioxidant action of ubiquinol: A reappraisal. Biofactors 9: 141-148, 1999.

·         Folkers, K. et al.  Effect of coenzyme Q10 on serum levels of creatine phosphokinase in preclinical muscular dystrophy.  Proceedings of the National Academy of Sciences USA 71: 2098, 1974.

·         Folkers, K. et al.  Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10.  Proceedings of the National Academy of Sciences USA 82: 4513, 1985.

·         Chen Y.F., Lin Y.T. and Wu S.C.  Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest.  Journal of Thoracic and Cardiovascular Surgery 107: 242-247, 1994.

·         Murray, M.T.  Encyclopedia of Natural Medicine, Rocklin, CA, Prima Publishing, 1998.

·         Folkers, K et al. The activities of coenzyme and vitamin B6 for immune responses.  Biochemical and Biophysical Research Communications 193: 88-92, 1993.

·         Folkers, K et al. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS-related complex.  Biochemical and Biophysical Research Communications 176: 25.

·         Lockwood, K. et al. Partial and complete regression of breast cancer in patients in relation to dosage of Coenzyme Q10.  Biomedical and Biophysical Research Communications 199: 1504-1508, 1994.

·         Nakamura, R. et al. Study of Co Q10-enzymes in gingival tissues from patients with periodontal disease and evidence for a deficiency of coenzyme Q10.  Proceedings of the National Academy of Sciences USA 71: 1456, 1974.

·         Littarru, G.P. et al. Deficiency of coenzyme Q10 in gingival tissue from patients with periodontal disease. Proceedings of National Academy of Sciences USA 68: 2332, 1971.

What is CoQ10?

CoQ10 stands for coenzyme Q10 and can be found in all cells in the human body except mature red blood cells.  CoQ10 is a fat-soluble coenzyme and is an essential component in the action of enzymes.  CoQ10 is also a powerful antioxidant with a structure very similar to vitamins E and K.  As an antioxidant, CoQ10 scavenges oxygen radicals in the mitochondria, rendering them unable to do harm.  Additionally, CoQ10 plays an integral role in energy production in the body. Since nearly all cellular activities are dependent upon energy, coenzyme Q10 is essential for the health of all human tissues and organs. Unfortunately, CoQ10 concentrations within the body naturally decrease with age and can be maintained via supplementation.* 

What Makes Heart Health™ Chewable CoQ10 Unique?

Heart Health™ Chewable CoQ10 is formulated using technology that allows the tablet to begin dissolving immediately when placed in contact with saliva. As the tablet dissolves, the liquid is swallowed, resulting in rapid delivery of CoQ10 to the blood stream.  Heart Health Chewable CoQ10 delivers natural CoQ10 to the bloodstream over twice as fast as other forms.  All the benefits of coenzyme Q10 can be achieved through a chewable tablet. Many people who have difficulty swallowing pills will find Heart Health Chewable CoQ10 a convenient way to add this important nutrient to their diet.*

Frequently Asked Questions Found In Heart Health™ Chewable CoQ10:

If my body makes CoQ10, why should I take a supplement?
When you are young, your body can produce adequate levels of CoQ10. However, as you get older, your cells do not produce enough of the energy they need to function well. Supplementation of CoQ10 has been shown to raise blood levels of this coenzyme when the body’s ability to synthesize it begins to decrease.

What is the recommended serving size of Heart Health Chewable Q10?

CoQ10 has been used in maintenance servings of 30-60 mg, but can go up to 100 mg or more. 

Is there a certain time I should take Heart Health Chewable Q10 CoQ10?

Coenzyme Q10 should be taken with a meal containing some fat. However, taking it in combination with soy or vegetable oil substantially enhances it absorption. 

Is it okay to take a CoQ10 supplement while pregnant or nursing?

No. The safety of coenzyme Q10 has not been established in pregnancy and lactation.   

Is it safe to take CoQ10?

Yes, it is safe to take CoQ10; it does not produce any toxic side effects when ingested by humans or animals. It is listed in the 42nd edition of the Physicians’ Desk Reference as replacement therapy for a nutrient, and no adverse reactions are listed.

What are the benefits of taking Heart Health Chewable CoQ10?

With its rapid delivery system, Heart Health Chewable Q10 enhances traditional support of cardiovascular health, helps maintain healthy blood sugar levels, helps maintain heart muscle strength and helps maintain normal blood pressure.*

Are there any allergens associated with Heart Health Chewable CoQ10?

There are no known allergens or no adverse side effects reported with taking Heart Health Chewable CoQ10.

Primary Benefits of Heart Health™ Chewable CoQ10*:

·        Enhances support of cardiovascular health

·        Helps maintain healthy blood sugar levels

·        Helps maintain heart muscle strength

·        Helps maintain normal blood pressure

·        Promotes/boosts the immune system

·        Promotes cardiovascular health

·        Promotes gum health

·        Promotes head comfort

·        Helps maintain healthy cholesterol levels

·        Provides antioxidant protection for the cardiovascular system

·        Supports/helps maintain brain health

·        Vital for ATP production and supports muscle endurance

Key Ingredients Found In Heart Health™ Chewable CoQ10:

Natural Coenzyme Q10: 100 mg

Coenzyme Q10 belongs to a family of substances called ubiquinones, and is a water-insoluble, wax-like substance that is part of the respiratory chain. Since it is a coenzyme, it is necessary to support the action of an enzyme, and it has a similar structure to vitamin K. CoQ10 is found in each of the 50-75 trillion cells throughout the body, except for mature red blood cells. It has a multitude of health benefits at the cellular level, in the cardiovascular system, and in metabolic processes. It serves to revitalize and energize the body’s cells and immune system and contributes to increases in stamina and endurance by fueling the body’s energy production (ATP) cycle. It is beneficial to the cardiovascular system because it helps to protect the heart, helps maintain normal blood pressure, and promotes mental alertness and normal brain activity.*

The mechanism of action of supplemental coenzyme Q10 has yet to be clarified, and is a matter of much speculation. However, much is known about the biochemistry of CoQ10. Coenzyme Q10 is a two-part compound that is composed of a long, fat-soluble isoprenoid tail that anchors the molecule in the inner membrane of the mitochondria, and quinine that is capable of accepting and transferring electrons through a portion of the respiratory chain. The “Q” stands for quinine and the “10” stands for the number of isoprenoid units in the tail portion of the molecule. It is synthesized in the cells, and is involved in electron transport and energy production in mitochondria. In the cellular system, it functions to generate energy from oxygen, in the form of ATP, for bodily processes. It serves as a free-radical scavenger and an antioxidant. The antioxidant activity in the mitochondria and cell membranes promotes the stability and health of lipid membranes.*

Heart Health™ Chewable CoQ10 supplies naturally fermented coenzyme Q10 in a great tasting, natural citrus-flavored chewable tablet.  It is formulated using patented fast melt technology designed to allow the tablet to begin dissolving immediately upon contact with saliva.  As the tablet melts the liquid is swallowed and it’s rapidly delivered into the blood stream so that your cardiovascular system, immune system, and more importantly, your body receives the great benefits of CoQ10.*

Scientific Studies Which Support Heart Health™ Chewable CoQ10:

·         Kagan, V, et al.  Coenzyme Q: Its role in scavenging and generation of radicals in membranes.  In Handbook of Antioxidants, eds.  Enrique Cadenas and Lester Packer, New York, Marcel Dekker, Inc., 1996, pp. 157-201.

·         Littarru, G.P. et al.  Clinical aspects of coenzyme Q: Improvement of cellular bioenergetics or antioxidant protection?  In Handbook of Antioxidants, eds. E. Cadenas and L. Packer: New York, Marcel Dekker, Inc., 1996, pp. 203-239.

·         Greenberg, S. and Frishman, W.H.  Coenzyme Q10: A new drug for cardiovascular disease.  Journal of Clinical Pharmacology 30: 596-608, 1990.

·         Chello, M, et al.  Protection of coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting.  Annals of Thoracic Surgery 58: 1427-1432, 1994.

·         Lansjoen, P.H. et al.  Response of patients in classes III and IV of cardiomyopathy to therapy in a blind crossover trial with coenzyme Q10.  Proceedings of the National Academy of Sciences USA 82: 4240, 1985.

·         Stryer, L. Biochemistry, 2nd ed. New York, W.H. Freeman and Company, 1981.

·         Firstein, R. The Nutraceutical Revolution. New York, Riverhead Books, 1998.

·         Frei, B, et al. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.  Proceedings of the National Academy of Sciences USA 87: 4879-4883, 1990.

·         Hanaki, Y. et al. Ratio of low-density lipoprotein cholesterol to ubiquinone as a coronary risk factor: New England Journal of Medicine, 325: 814-815, 1991.

·         Singh R.B. and Singh M.M.  Effects of coenzyme Q10 in new indications with antioxidant vitamin deficiency. Journal of Nutritional and Environmental Medicine 9: 223-228, 1999.

·         Greenburg S. and Frishman W. Coenzyme Q10: A new drug from myocardial ischemia? Medical Clinics of North America 72: 243-58, 1998.

·         Langsjoen, P.H. et al.  Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy.  International Journal of Tissue Reactions 12: 163-168, 1990.

·         Digiesi, V. et al. Mechanism of action of coenzyme Q10 in essential hypertension.  Current Therapy and Research 51: 668-672, 1992.

·         Sunamori, M. et al. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovascular Drugs and Therapy 5: 297-300, 1991.

·         Langsjoen, P.H. et al. A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10.  International Journal of Tissue Reactions 12: 169-71, 199.

·         Stocker, R. et al. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proceedings of the National Academy of Sciences USA 88: 1646-1650, 1991.

·         Shi, H. and Noguchi, N.  Dynamics of antioxidant action of ubiquinol: A reappraisal. Biofactors 9: 141-148, 1999.

·         Folkers, K. et al.  Effect of coenzyme Q10 on serum levels of creatine phosphokinase in preclinical muscular dystrophy.  Proceedings of the National Academy of Sciences USA 71: 2098, 1974.

·         Folkers, K. et al.  Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10.  Proceedings of the National Academy of Sciences USA 82: 4513, 1985.

·         Chen Y.F., Lin Y.T. and Wu S.C.  Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest.  Journal of Thoracic and Cardiovascular Surgery 107: 242-247, 1994.

·         Murray, M.T.  Encyclopedia of Natural Medicine, Rocklin, CA, Prima Publishing, 1998.

·         Folkers, K et al. The activities of coenzyme and vitamin B6 for immune responses.  Biochemical and Biophysical Research Communications 193: 88-92, 1993.

·         Folkers, K et al. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS-related complex.  Biochemical and Biophysical Research Communications 176: 25.

·         Lockwood, K. et al. Partial and complete regression of breast cancer in patients in relation to dosage of Coenzyme Q10.  Biomedical and Biophysical Research Communications 199: 1504-1508, 1994.

·         Nakamura, R. et al. Study of Co Q10-enzymes in gingival tissues from patients with periodontal disease and evidence for a deficiency of coenzyme Q10.  Proceedings of the National Academy of Sciences USA 71: 1456, 1974.

·         Littarru, G.P. et al. Deficiency of coenzyme Q10 in gingival tissue from patients with periodontal disease. Proceedings of National Academy of Sciences USA 68: 2332, 1971.

What is CoQ10?

CoQ10 stands for coenzyme Q10 and can be found in all cells in the human body except mature red blood cells.  CoQ10 is a fat-soluble coenzyme and is an essential component in the action of enzymes.  CoQ10 is also a powerful antioxidant with a structure very similar to vitamins E and K.  As an antioxidant, CoQ10 scavenges oxygen radicals in the mitochondria, rendering them unable to do harm.  Additionally, CoQ10 plays an integral role in energy production in the body. Since nearly all cellular activities are dependent upon energy, coenzyme Q10 is essential for the health of all human tissues and organs. Unfortunately, CoQ10 concentrations within the body naturally decrease with age and can be maintained via supplementation.* 

What Makes Heart Health™ Chewable CoQ10 Unique?

Heart Health™ Chewable CoQ10 is formulated using technology that allows the tablet to begin dissolving immediately when placed in contact with saliva. As the tablet dissolves, the liquid is swallowed, resulting in rapid delivery of CoQ10 to the blood stream.  Heart Health Chewable CoQ10 delivers natural CoQ10 to the bloodstream over twice as fast as other forms.  All the benefits of coenzyme Q10 can be achieved through a chewable tablet. Many people who have difficulty swallowing pills will find Heart Health Chewable CoQ10 a convenient way to add this important nutrient to their diet.*

Frequently Asked Questions Found In Heart Health™ Chewable CoQ10:

If my body makes CoQ10, why should I take a supplement?
When you are young, your body can produce adequate levels of CoQ10. However, as you get older, your cells do not produce enough of the energy they need to function well. Supplementation of CoQ10 has been shown to raise blood levels of this coenzyme when the body’s ability to synthesize it begins to decrease.

What is the recommended serving size of Heart Health Chewable Q10?

CoQ10 has been used in maintenance servings of 30-60 mg, but can go up to 100 mg or more. 

Is there a certain time I should take Heart Health Chewable Q10 CoQ10?

Coenzyme Q10 should be taken with a meal containing some fat. However, taking it in combination with soy or vegetable oil substantially enhances it absorption. 

Is it okay to take a CoQ10 supplement while pregnant or nursing?

No. The safety of coenzyme Q10 has not been established in pregnancy and lactation.   

Is it safe to take CoQ10?

Yes, it is safe to take CoQ10; it does not produce any toxic side effects when ingested by humans or animals. It is listed in the 42nd edition of the Physicians’ Desk Reference as replacement therapy for a nutrient, and no adverse reactions are listed.

What are the benefits of taking Heart Health Chewable CoQ10?

With its rapid delivery system, Heart Health Chewable Q10 enhances traditional support of cardiovascular health, helps maintain healthy blood sugar levels, helps maintain heart muscle strength and helps maintain normal blood pressure.*

Are there any allergens associated with Heart Health Chewable CoQ10?

There are no known allergens or no adverse side effects reported with taking Heart Health Chewable CoQ10.