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Primary Benefits of Heart Health™ Advanced CoEnzyme Q10: - Promotes cardiovascular health
- Helps boost the immune system
Key Ingredients found in Heart Health™ Advanced CoEnzyme Q10: Coenzyme Q10 Coenzyme Q10 belongs to a family of substances called ubiquinones, a wax-like substance, which is part of the respiratory chain. Since it is a coenzyme, it is necessary to support the action of an enzyme, and it has a similar structure to vitamin K. CoQ10 is found in each of the 50-75 trillion cells throughout the body, except for the mature red blood cells. It has a multitude of therapeutic benefits at the cellular level, in the cardiovascular system and with the body’s metabolism. It serves to revitalize and energize the body’s cells and immune system. It contributes to increases in stamina and endurance by fueling the body’s energy production (ATP) cycle. It is beneficial to the cardiovascular system because it helps to protect and strengthen the heart, normalizes blood pressure without side effects. Coenzyme Q10 is a two-part compound that is composed of a long, fat-soluble isoprenoid tail that anchors the molecule in the inner membrane of the mitochondria, and quinine that is capable of accepting and transferring electrons through a portion of the respiratory chain. The Q stands for quinine and the 10 stands for the number of isoprenoid units in the tail portion of the molecule. It is synthesized in the cells, and is involved in electron transport and energy production in mitochondria. In the cellular system, it functions to generate energy from oxygen, in the form of ATP, for bodily processes. According to many published monograph and articles, since ATP is known to generate many harmful oxygen radicals, CoQ10 serves as a free radical scavenger and an antioxidant. The antioxidant activity in the mitochondria and cell membranes protects against peroxidation of lipid membranes. In cholesterol patients, CoQ10 works with vitamin E outside the cell to restrain the oxidation of LDL-cholesterol, which plays a significant role in pathogenesis and atherosclerosis. Combining CoQ10 with vitamin E generates a synergistic antioxidant effect on lipoprotein and Q10 spares the vitamin E. Coenzyme Q10 can be found in spinach, broccoli, nuts, soy, organ and muscle meats, and fish. In 1977, a Japanese company succeeded in synthesizing coenzyme Q10, which made the nutrient available to the world. The recommended daily dose is 30 mg per day, however there have been no toxic effects should at daily doses as high as 390 mg. In the body, it is found in the highest concentration in the cells of the heart, liver, kidney and pancreas. The liver produces small amounts of CoQ10, and then this is distributed to the rest of the body. Supplementation of CoQ10 might be most beneficial to adults, because the levels of it in the body tend to peak around the age of 20 and then decline with age. It has been documented that those who have significantly lower tissue concentrations of CoQ10, have shown health problems such as congestive heart failure, cardiomyopathy, angina pectoris, and chronic gum disease. Also, cancer patients receiving the anti-cancer drug Adriamycin and people taking cholesterol-lowering drugs of the HMG-coenzyme A reductase class are at risk for coenzyme Q10 deficiency. Strenuous exercise reduces blood levels of CoQ10 and supplementation with 60 mg per day can improve athletic performance. Supplementation may also help many overweight individuals because it has been shown that they usually have low levels of coenzyme Q10. CoQ10 may help to maintain a normal body weight through enhanced metabolism of fat. Vitamin E Vitamin E is one of the most powerful, fat-soluble antioxidants in the body, and it helps protect cell membranes from the damage caused by free radicals. High doses of vitamin E have been found to reduce the risk of heart attacks. Vegetable oils, margarine, nuts, seeds, avocados, wheat germ and safflower oil are all good food sources of vitamin E. Those individuals who are watching their fat consumption are likely to have a low intake of vitamin E. Vitamin E is linked to improved cardiovascular health, enhanced immune system function and topical wound healing. Vitamin E is a family of related compounds known as tocopherols and tocotrienols. The most common form of the vitamin is alpha-tocopherol, which is found in dietary supplements. However, vitamin E also exists with a slightly different chemical structure as beta-, gamma- and delta-tocotrienols. Vitamin E was discovered in the early 1930s when rats that were fed a diet free of vegetable oils, which is a primary source of vitamin E, had reproductive problems. Vitamin E does not have the same effects in humans as it does in rats. Vitamin E can be obtained as a supplement in a natural or synthetic form, but the natural form is far more superior in terms of retention in the body and absorption.
In the News: Body's Energy-Producing Component May Serve As an Antioxidant By Michael Murray, N.D. WebMD |
A Supplement for Your Heart Can the supplement coenzyme Q10 help my heart problems? May 22, 2000 Coenzyme Q10 May Slow Parkinson's High Doses of Popular Supplement Delays Deterioration By Sid Kirchheimer
WebMD Medical News | Reviewed By Michael Smith, MD
on Monday, October 14, 2002 |
More support for CoQ10's benefits for heart health
By Stephen Daniells 12/09/2006 Nutraingredients.com Women on the pill could benefit from Q10, vit E
By Stephen Daniells 07/06/2006 Nutraingredients.com Coenzyme Q10: It May Just Be the Miracle Vitamin of the 1990s 12/04/96 ¡V www.thenutritionreporter.com Coenzyme Q10 American Academy of Family Physicians 2005 ¡V www.aafp.org CoQ10 boosts vitamin E's anti-inflammatory action 08/09/2004 ¡V www.nutraingredients.com
Scientific Support for Heart Health™ Advanced CoEnzyme Q10: o Kagan, V, et al. Coenzyme Q: Its role in scavenging and generation of radicals in membranes. In Handbook of Antioxidants, eds. Enrique Cadenas and Lester Packer, New York, Marcel Dekker, Inc., 1996, pp. 157-201. o Littarru, G.P. et al. Clinical aspects of coenzyme Q: Improvement of cellular bioenergetics or antioxidant protection? In Handbook of Antioxidants, eds.E. Cadenas and L. Packer: New York, Marcel Dekker, Inc., 1996, pp. 203-239. o Greenberg, S. and Frishman, W.H. Coenzyme Q10: A new drug for cardiovascular disease. Journal of Clinical Pharmacology 30: 596-608, 1990. o Chello, M, et al. Protection of coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Annals of Thoracic Surgery 58: 1427-1432, 1994. o Lansjoen, P.H. et al. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind crossover trial with coenzyme Q10. Proceedings of the National Academy of Sciences USA 82: 4240, 1985. o Stryer, L. Biochemistry, 2nd ed. New York, W.H. Freeman and Company, 1981. o Firstein, R. The Nutraceutical Revolution. New York, Riverhead Books, 1998. o Frei, B, et al. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proceedings of the National Academy of Sciences USA 87: 4879-4883, 1990. o Hanaki, Y. et al. Ratio of low-density lipoprotein cholesterol to ubiquinone as a coronary risk factor: New England Journal of Medicine, 325: 814-815, 1991. o Singh R.B. and Singh M.M. Effects of coenzyme Q10 in new indications with antioxidant vitamin deficiency. Journal of Nutritional and Environmental Medicine 9: 223-228, 1999. o Greenburg S. and Frishman W. Coenzyme Q10: A new drug from myocardial ischemia? Medical Clinics of North America 72: 243-58, 1998. o Langsjoen, P.H. et al. Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy. International Journal of Tissue Reactions 12: 163-168, 1990. o Digiesi, V. et al. Mechanism of action of coenzyme Q10 in essential hypertension. Current Therapy and Research 51: 668-672, 1992. o Sunamori, M. et al. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovascular Drugs and Therapy 5: 297-300, 1991. o Langsjoen, P.H. et al. A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10. International Journal of Tissue Reactions 12: 169-71, 199. o Stocker, R. et al. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proceedings of the National Academy of Sciences USA 88: 1646-1650, 1991. o Shi, H. and Noguchi, N. Dynamics of antioxidant action of ubiquinol: A reappraisal. Biofactors 9: 141-148, 1999. o Folkers, K. et al. Effect of coenzyme Q10 on serum levels of creatine phosphokinase in preclinical muscular dystrophy. Proceedings of the National Academy of Sciences USA 71: 2098, 1974. o Folkers, K. et al. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proceedings of the National Academy of Sciences USA 82: 4513, 1985. o Chen Y.F., Lin Y.T. and Wu S.C. Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest. Journal of Thoracic and Cardiovascular Surgery 107: 242-247, 1994. o Murray, M.T. Encyclopedia of Natural Medicine, Rocklin, CA, Prima Publishing, 1998. o Folkers, K et al. The activities of coenzyme and vitamin B6 for immune responses. Biochemical and Biophysical Research Communications 193: 88-92, 1993. o Folkers, K et al. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS-related complex. Biochemical and Biophysical Research Communications 176: 25. o Lockwood, K. et al. Partial and complete regression of breast cancer in patients in relation to dosage of Coenzyme Q10. Biomedical and Biophysical Research Communications 199: 1504-1508, 1994. o Nakamura, R. et al. Study of Co Q10-enzymes in gingival tissues from patients with periodontal disease and evidence for a deficiency of coenzyme Q10. Proceedings of the National Academy of Sciences USA 71: 1456, 1974. o Littarru, G.P. et al. Deficiency of coenzyme Q10 in gingival tissue from patients with periodontal disease. Proceedings of National Academy of Sciences USA 68: 2332, 1971.
What Makes Heart Health™ Advanced CoEnzyme Q10 Unique? Coenzyme Q10 is a nutrient that plays a vital role in health maintenance. It contributes to a healthy cardiovascular system, sustaining vitamin E levels in cell membranes, energizing the immune system and proper functions maintenance. A persons heart beats, on average, 100,000 times each day, which adds up to about 36 million times per year. CoQ10 is the vital nutrient that initiates the energy at the cellular level that powers the heart, the bodys energy production cycle. Thats why Advanced Coenzyme Q10 can help promote cardiovascular health and the immune system. As individuals age, the ability to synthesize coenzyme Q10 begins to decline. Sometimes this is due to poor eating habits, stress or infections, but the main challenge for most people is the ability to choose the right foods containing CoQ10, as well as the other nutrients needed to manufacture it in the body. It is a combination of both that provides the body with the best possible amount of CoQ10 for optimal health. Related terms: CoEnzyme Q10, CoQ10, heart health, immune system, cardiovascular health
Frequently Asked Questions about Heart Health™ Advanced CoEnzyme Q10 (FAQs): 1. What type of Vitamin E is in Advanced Coenzyme Q10? The natural form of vitamin E, d-Alpha-Tocopherol, is in Advanced Coenzyme Q10. It is far more superior in terms of retention in the body and absorption. 2. If my body makes CoQ10, why should I take a supplement?
When you are young, your body can produce adequate levels of CoQ10, but as you get older, your cells do not produce enough. Supplementation of CoQ10 has been shown to raise blood levels of this co-enzyme when the body's ability to synthesize it begins to decrease. 3. What is the recommended dosage of Coenzyme Q10? Coenzyme Q10 has been used in maintenance doses of 30-60 mg while therapeutic doses have gone up to 100 mg or more. Non-toxic effects have been reported for daily dosages as high 390 mg, but the recommended daily dose for health maintenance is 30 mg. 4. Is there a certain time I should take CoQ10? Coenzyme Q10 can be taken with a meal containing some fat. However, taking it in combination with soy or vegetable oil enhances it absorption substantially. 5. Is it okay to take a CoQ10 supplement while pregnant? The safety of coenzyme Q10 has not been established in pregnancy and lactation. Therefore, caution is advised in that area until more data becomes available. 6. Why don't more doctors use Coenzyme Q10? The reason why doctors don't use more coenzyme Q10, according to Dr. Peter Langsjoen, is due to politics and marketing, not because of science and medicine. 7. Is it safe to take CoQ10? Yes, it is safe to take CoQ10. It is safe and has not produced any toxic side effects when ingested by humans or animals. It is listed in the 42nd edition of the Physicians Desk Reference as replacement therapy for a nutrient and with no adverse reactions listed. 8. Are there any side effects reported from coenzyme Q10? No serious side effects have been reported, but some patients using coenzyme Q10 have experienced mild insomnia, elevated levels of liver enzymes, rashes, nausea, and upper abdominal pain. Other reported side effects include dizziness, visual sensitivity to light, irritability, headache, heartburn, and fatigue. If you take prescription drugs, you should speak with your doctor first, because there are certain drugs that may reduce the effects of CoQ10. It can also alter the body's response to warfarin and insulin. 9. Is it dangerous to have low levels of CoQ10 in your body? It can be dangerous to have lower levels of CoQ10 in your body. According to Dr. Karl Folkers, he has hypothesized that when CoQ10 levels drop below 75 percent, or a deficiency of 25 percent, the body would be more susceptible to illness and disease states. He also stated that when the levels drop below 25 percent, death would occur.
Primary Benefits of Heart Health™ Advanced CoEnzyme Q10: - Promotes cardiovascular health
- Helps boost the immune system
Key Ingredients found in Heart Health™ Advanced CoEnzyme Q10: Coenzyme Q10 Coenzyme Q10 belongs to a family of substances called ubiquinones, a wax-like substance, which is part of the respiratory chain. Since it is a coenzyme, it is necessary to support the action of an enzyme, and it has a similar structure to vitamin K. CoQ10 is found in each of the 50-75 trillion cells throughout the body, except for the mature red blood cells. It has a multitude of therapeutic benefits at the cellular level, in the cardiovascular system and with the body’s metabolism. It serves to revitalize and energize the body’s cells and immune system. It contributes to increases in stamina and endurance by fueling the body’s energy production (ATP) cycle. It is beneficial to the cardiovascular system because it helps to protect and strengthen the heart, normalizes blood pressure without side effects. Coenzyme Q10 is a two-part compound that is composed of a long, fat-soluble isoprenoid tail that anchors the molecule in the inner membrane of the mitochondria, and quinine that is capable of accepting and transferring electrons through a portion of the respiratory chain. The Q stands for quinine and the 10 stands for the number of isoprenoid units in the tail portion of the molecule. It is synthesized in the cells, and is involved in electron transport and energy production in mitochondria. In the cellular system, it functions to generate energy from oxygen, in the form of ATP, for bodily processes. According to many published monograph and articles, since ATP is known to generate many harmful oxygen radicals, CoQ10 serves as a free radical scavenger and an antioxidant. The antioxidant activity in the mitochondria and cell membranes protects against peroxidation of lipid membranes. In cholesterol patients, CoQ10 works with vitamin E outside the cell to restrain the oxidation of LDL-cholesterol, which plays a significant role in pathogenesis and atherosclerosis. Combining CoQ10 with vitamin E generates a synergistic antioxidant effect on lipoprotein and Q10 spares the vitamin E. Coenzyme Q10 can be found in spinach, broccoli, nuts, soy, organ and muscle meats, and fish. In 1977, a Japanese company succeeded in synthesizing coenzyme Q10, which made the nutrient available to the world. The recommended daily dose is 30 mg per day, however there have been no toxic effects should at daily doses as high as 390 mg. In the body, it is found in the highest concentration in the cells of the heart, liver, kidney and pancreas. The liver produces small amounts of CoQ10, and then this is distributed to the rest of the body. Supplementation of CoQ10 might be most beneficial to adults, because the levels of it in the body tend to peak around the age of 20 and then decline with age. It has been documented that those who have significantly lower tissue concentrations of CoQ10, have shown health problems such as congestive heart failure, cardiomyopathy, angina pectoris, and chronic gum disease. Also, cancer patients receiving the anti-cancer drug Adriamycin and people taking cholesterol-lowering drugs of the HMG-coenzyme A reductase class are at risk for coenzyme Q10 deficiency. Strenuous exercise reduces blood levels of CoQ10 and supplementation with 60 mg per day can improve athletic performance. Supplementation may also help many overweight individuals because it has been shown that they usually have low levels of coenzyme Q10. CoQ10 may help to maintain a normal body weight through enhanced metabolism of fat. Vitamin E Vitamin E is one of the most powerful, fat-soluble antioxidants in the body, and it helps protect cell membranes from the damage caused by free radicals. High doses of vitamin E have been found to reduce the risk of heart attacks. Vegetable oils, margarine, nuts, seeds, avocados, wheat germ and safflower oil are all good food sources of vitamin E. Those individuals who are watching their fat consumption are likely to have a low intake of vitamin E. Vitamin E is linked to improved cardiovascular health, enhanced immune system function and topical wound healing. Vitamin E is a family of related compounds known as tocopherols and tocotrienols. The most common form of the vitamin is alpha-tocopherol, which is found in dietary supplements. However, vitamin E also exists with a slightly different chemical structure as beta-, gamma- and delta-tocotrienols. Vitamin E was discovered in the early 1930s when rats that were fed a diet free of vegetable oils, which is a primary source of vitamin E, had reproductive problems. Vitamin E does not have the same effects in humans as it does in rats. Vitamin E can be obtained as a supplement in a natural or synthetic form, but the natural form is far more superior in terms of retention in the body and absorption. In the News: Body's Energy-Producing Component May Serve As an Antioxidant By Michael Murray, N.D. WebMD |
A Supplement for Your Heart Can the supplement coenzyme Q10 help my heart problems? May 22, 2000 Coenzyme Q10 May Slow Parkinson's High Doses of Popular Supplement Delays Deterioration By Sid Kirchheimer
WebMD Medical News | Reviewed By Michael Smith, MD
on Monday, October 14, 2002 |
More support for CoQ10's benefits for heart health
By Stephen Daniells 12/09/2006 Nutraingredients.com Women on the pill could benefit from Q10, vit E
By Stephen Daniells 07/06/2006 Nutraingredients.com Coenzyme Q10: It May Just Be the Miracle Vitamin of the 1990s 12/04/96 ¡V www.thenutritionreporter.com Coenzyme Q10 American Academy of Family Physicians 2005 ¡V www.aafp.org CoQ10 boosts vitamin E's anti-inflammatory action 08/09/2004 ¡V www.nutraingredients.com Scientific Support for Heart Health™ Advanced CoEnzyme Q10: o Kagan, V, et al. Coenzyme Q: Its role in scavenging and generation of radicals in membranes. In Handbook of Antioxidants, eds. Enrique Cadenas and Lester Packer, New York, Marcel Dekker, Inc., 1996, pp. 157-201. o Littarru, G.P. et al. Clinical aspects of coenzyme Q: Improvement of cellular bioenergetics or antioxidant protection? In Handbook of Antioxidants, eds.E. Cadenas and L. Packer: New York, Marcel Dekker, Inc., 1996, pp. 203-239. o Greenberg, S. and Frishman, W.H. Coenzyme Q10: A new drug for cardiovascular disease. Journal of Clinical Pharmacology 30: 596-608, 1990. o Chello, M, et al. Protection of coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Annals of Thoracic Surgery 58: 1427-1432, 1994. o Lansjoen, P.H. et al. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind crossover trial with coenzyme Q10. Proceedings of the National Academy of Sciences USA 82: 4240, 1985. o Stryer, L. Biochemistry, 2nd ed. New York, W.H. Freeman and Company, 1981. o Firstein, R. The Nutraceutical Revolution. New York, Riverhead Books, 1998. o Frei, B, et al. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proceedings of the National Academy of Sciences USA 87: 4879-4883, 1990. o Hanaki, Y. et al. Ratio of low-density lipoprotein cholesterol to ubiquinone as a coronary risk factor: New England Journal of Medicine, 325: 814-815, 1991. o Singh R.B. and Singh M.M. Effects of coenzyme Q10 in new indications with antioxidant vitamin deficiency. Journal of Nutritional and Environmental Medicine 9: 223-228, 1999. o Greenburg S. and Frishman W. Coenzyme Q10: A new drug from myocardial ischemia? Medical Clinics of North America 72: 243-58, 1998. o Langsjoen, P.H. et al. Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy. International Journal of Tissue Reactions 12: 163-168, 1990. o Digiesi, V. et al. Mechanism of action of coenzyme Q10 in essential hypertension. Current Therapy and Research 51: 668-672, 1992. o Sunamori, M. et al. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovascular Drugs and Therapy 5: 297-300, 1991. o Langsjoen, P.H. et al. A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10. International Journal of Tissue Reactions 12: 169-71, 199. o Stocker, R. et al. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proceedings of the National Academy of Sciences USA 88: 1646-1650, 1991. o Shi, H. and Noguchi, N. Dynamics of antioxidant action of ubiquinol: A reappraisal. Biofactors 9: 141-148, 1999. o Folkers, K. et al. Effect of coenzyme Q10 on serum levels of creatine phosphokinase in preclinical muscular dystrophy. Proceedings of the National Academy of Sciences USA 71: 2098, 1974. o Folkers, K. et al. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proceedings of the National Academy of Sciences USA 82: 4513, 1985. o Chen Y.F., Lin Y.T. and Wu S.C. Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest. Journal of Thoracic and Cardiovascular Surgery 107: 242-247, 1994. o Murray, M.T. Encyclopedia of Natural Medicine, Rocklin, CA, Prima Publishing, 1998. o Folkers, K et al. The activities of coenzyme and vitamin B6 for immune responses. Biochemical and Biophysical Research Communications 193: 88-92, 1993. o Folkers, K et al. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS-related complex. Biochemical and Biophysical Research Communications 176: 25. o Lockwood, K. et al. Partial and complete regression of breast cancer in patients in relation to dosage of Coenzyme Q10. Biomedical and Biophysical Research Communications 199: 1504-1508, 1994. o Nakamura, R. et al. Study of Co Q10-enzymes in gingival tissues from patients with periodontal disease and evidence for a deficiency of coenzyme Q10. Proceedings of the National Academy of Sciences USA 71: 1456, 1974. o Littarru, G.P. et al. Deficiency of coenzyme Q10 in gingival tissue from patients with periodontal disease. Proceedings of National Academy of Sciences USA 68: 2332, 1971. What Makes Heart Health™ Advanced CoEnzyme Q10 Unique? Coenzyme Q10 is a nutrient that plays a vital role in health maintenance. It contributes to a healthy cardiovascular system, sustaining vitamin E levels in cell membranes, energizing the immune system and proper functions maintenance. A persons heart beats, on average, 100,000 times each day, which adds up to about 36 million times per year. CoQ10 is the vital nutrient that initiates the energy at the cellular level that powers the heart, the bodys energy production cycle. Thats why Advanced Coenzyme Q10 can help promote cardiovascular health and the immune system. As individuals age, the ability to synthesize coenzyme Q10 begins to decline. Sometimes this is due to poor eating habits, stress or infections, but the main challenge for most people is the ability to choose the right foods containing CoQ10, as well as the other nutrients needed to manufacture it in the body. It is a combination of both that provides the body with the best possible amount of CoQ10 for optimal health. Related terms: CoEnzyme Q10, CoQ10, heart health, immune system, cardiovascular health Frequently Asked Questions about Heart Health™ Advanced CoEnzyme Q10 (FAQs): 1. What type of Vitamin E is in Advanced Coenzyme Q10? The natural form of vitamin E, d-Alpha-Tocopherol, is in Advanced Coenzyme Q10. It is far more superior in terms of retention in the body and absorption. 2. If my body makes CoQ10, why should I take a supplement?
When you are young, your body can produce adequate levels of CoQ10, but as you get older, your cells do not produce enough. Supplementation of CoQ10 has been shown to raise blood levels of this co-enzyme when the body's ability to synthesize it begins to decrease. 3. What is the recommended dosage of Coenzyme Q10? Coenzyme Q10 has been used in maintenance doses of 30-60 mg while therapeutic doses have gone up to 100 mg or more. Non-toxic effects have been reported for daily dosages as high 390 mg, but the recommended daily dose for health maintenance is 30 mg. 4. Is there a certain time I should take CoQ10? Coenzyme Q10 can be taken with a meal containing some fat. However, taking it in combination with soy or vegetable oil enhances it absorption substantially. 5. Is it okay to take a CoQ10 supplement while pregnant? The safety of coenzyme Q10 has not been established in pregnancy and lactation. Therefore, caution is advised in that area until more data becomes available. 6. Why don't more doctors use Coenzyme Q10? The reason why doctors don't use more coenzyme Q10, according to Dr. Peter Langsjoen, is due to politics and marketing, not because of science and medicine. 7. Is it safe to take CoQ10? Yes, it is safe to take CoQ10. It is safe and has not produced any toxic side effects when ingested by humans or animals. It is listed in the 42nd edition of the Physicians Desk Reference as replacement therapy for a nutrient and with no adverse reactions listed. 8. Are there any side effects reported from coenzyme Q10? No serious side effects have been reported, but some patients using coenzyme Q10 have experienced mild insomnia, elevated levels of liver enzymes, rashes, nausea, and upper abdominal pain. Other reported side effects include dizziness, visual sensitivity to light, irritability, headache, heartburn, and fatigue. If you take prescription drugs, you should speak with your doctor first, because there are certain drugs that may reduce the effects of CoQ10. It can also alter the body's response to warfarin and insulin. 9. Is it dangerous to have low levels of CoQ10 in your body? It can be dangerous to have lower levels of CoQ10 in your body. According to Dr. Karl Folkers, he has hypothesized that when CoQ10 levels drop below 75 percent, or a deficiency of 25 percent, the body would be more susceptible to illness and disease states. He also stated that when the levels drop below 25 percent, death would occur.
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