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Key Ingredients: Grape Seed Extract 25 mg Grape seed extract are seeds typically from red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). The OPCs are also present in a wide variety of fruits and vegetables, including pine bark (Pycnogenol®) and green tea, where, like grape seed extract, they possess potent antioxidant properties. These antioxidants help protect cells from free-radical damage, and promote cardiovascular health and vision health. Grape seed extract is extremely rich in polyphenols, a compound that’s high in antioxidants. French research on grape seed antioxidant activity and safety is highly credible, because the French government actually categorizes the OPC from grape seed as a pharmaceutical product, like American drugs prescribed by a family doctor. Red Wine Extract 25 mg Red wine is a naturally occurring antioxidant. It occurs naturally in grape vines, roots, seeds and stalks, with its highest concentration in the skins. Red wine is significantly higher in antioxidant properties than in white wine. This brings up the concept of the French-paradox. In the late 1990s, scientists took note of a phenomenon among the French. There were and still are very high rates of heart health in the provinces where residents consistently ate high fat foods and drank red wine. The protective properties of red wine have protected the heart health of the French for years and subsequent scientific studies have proven the fact that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels. In test tube and animal studies, red wine extract helped blood vessels remain open and flexible. Pine Bark Extract 25 mg (Pycnogenol®) Pycnogenol® is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest The extract has three basic properties — it’s a powerful antioxidant, selectively binds to collagen and elastin, and finally, it aids in the production of endothelial nitric oxide which promotes healthy vasolikation of blood vessels. As one of the most potent natural scavenger of free radicals, Pycnogenol® mops-up all kinds of aggressive radicals before they cause any damage via oxidative stress. Its super-antioxidant capabilities help boost the immune system and it strengthens blood vessel walls and capillaries. It helps maintain healthy circulation and cell vitality. Today, Pycnogenol® is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol®’s beneficial effects in cardiovascular health, eye health, skincare, and sports nutrition, among others. Bilberry Extract 25mg Bilberry extract is derived from the leaves and berry like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins. They act as powerful antioxidants. Scientific studies confirm to promote vision and vein health. Bilberry extract strengthens capillaries and arteries. Bilberry is nontoxic. Citrus Extract (Bioflavonoids) 25 mg Bioflavonoids are found in certain plants and act as light filters protecting the delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. Bioflavonoids have been shown to support liver health. This product is not intended to diagnose, treat, cure or prevent any disease. In the News: Grape Seed Extract for Blood Pressure?
SOURCES: American Chemical Society National Meeting & Exposition,
Scientific Studies: o Bertelli AA, Giovanninni L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61–3. o Petri G, Krawczyk U, Kery A. Spectrophotometric and chromatographic investigation of bilberry anthocyanins for qualification purposes. Acta Pharm Hung. 1994 Jul;64(4):117-22. o Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol 1996;27:363–6. o Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163–82. o Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997;275:218–20. o Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Rohdewald, P. Pycnoge0nol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998. o Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002. o Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999. o Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997. o Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993. o Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004. o Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004. o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994. o Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000. o Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000. o Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY o Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh o Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000. o Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. o Huynh HT, Teel RW. Effects of pycnogenol on the microsomal metabolism of the tobacco-specific nitrosamine NNK as a function of age. Cancer Lett. 1998; 132:135-139. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002. o Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001. o Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996. o Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994. o Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998. o Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000. o Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY o Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998. o Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh o Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997. o Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994. o Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998. o Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000. o Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY o Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998. o Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh o Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997. o Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004. o Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003. o Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004. o Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004. o Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999. o Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002. o Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999. o Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004. o Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review. o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994. o Sato M, Maulik G, Ray PS, et al. Cardioprotective effects of grape seed proanthocyanidins against ischemic reperfusion injury. J Mol Cell Cardiol. 1999; 31:1289-1297 o Yamakoshi J, Kataoka S, Koga T, Ariga T. Proanthocyanidin-rich extract from grape seed attenuates the development of aortic atherosclerosis in cholesterol-fed rabbis. Atherosclerosis. 1999; 142:139-149. o Araghi-Niknam M, Hosseini S, Larson D, Rohdewald P, Watson RR. Pine bark extract reduces platelet aggregation. Integr. Med..2000 Mar 21;2(2):73-77 o Miztuani K, Ikeda K, Kawai Y, Yamori Y. Extract of wine phenolics improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats (SHRSP). J Nutr Sci Vitaminol ( What Makes This Product Unique? Isotonix OPC-3® is an isotonic-capable dietary supplement that is made from a combination of grape seed, red wine and pine bark extracts. To clarify, when speaking of isotonic supplements, we mean the way dietary supplements are absorbed by your body. Taken orally, Isotonic supplements bear chemical resemblance to your own tears, intravenous fluids and plasma, so in turn, your bodily systems welcome the assimilation and integration of this product. Next, Isotonix OPC-3 offers exclusive OPC ingredients, which are scientifically proven to be the most potent in antioxidant activity, which is vital for human health. In addition to being powerful antioxidants, the individual OPCs in Isotonix OPC-3 have been shown in humans to provide benefits for many various specific health concerns. This science-driven selection makes Isotonix OPC-3 the most powerful, natural free-radical scavenger, anti-aging and cardiovascular health protecting product ever created. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (or complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be up to many times more powerful than Vitamin C and Vitamin E. The purest and best researched OPCs chosen for Isotonix OPC-3 are prepared from grapes, bilberries, Pycnogenol® from pine bark and citrus fruit. At the top of the ingredient list, the grape seed extract is a superior source of OPC, containing 92 percent of active ingredients with pine bark containing 84 percent of active OPC ingredients. The red wine extract contains flavonoids called leucocyanidins from the skin of red grapes. These are the three best sources of oligometric proanthocyanidins available and are all contained in Isotonix OPC-3. Over 20,000 different flavonoids have been discovered, of which a select few are water-soluble and easily absorbed by the body. The bioflavonoids found in Isotonix OPC-3 are the most potent and bio-available. These are called Pycnogenol®, a name coined by scientist Dr. Jacques Masquelier, a professor at the University of Bordeaux, France. Isotonix OPC-3 also contains two additional sources of bioflavonoids: bilberry and citrus extracts. Isotonix OPC-3 is superior to any other OPC supplement in total polyphenol content, active ingredients quality and isotonic capability. Isotonix OPC-3 is the most powerful free radical neutralizer available. Isotonix OPC-3 has a pleasant, natural grape flavor and is a vegetarian product. This product is not intended to diagnose, treat, cure or prevent any disease. Frequently Asked Questions: What is Isotonix OPC-3®? Isotonix OPC-3 is a natural food supplement that bears as active ingredients the most powerful bioflavonoids currently known to research scientists. These bioflavonoids are scientifically termed "oligomeric proanthocyanidins", commonly abbreviated OPC. The purest and best-researched OPCs chosen for Isotonix OPC-3 are prepared from grapes, bilberries, Pycnogenol from pine bark and citrus fruit. They are rated the highest in terms of total polyphenol content. As well as being powerful antioxidants, scavenging free radicals, the individual OPCs are known to have special merits for certain parts of the body. These super powerful bioflavanoids are considered many times more potent than vitamins C and E as free-radical scavengers. They do, however, work with both vitamin C and E to form an effective antioxidant network within the membranes and cytoplasm of cells. It strengthens capillary, arteries, veins and promotes healthy circulation, making it easier for cells to assimilate food. This combination of potent OPCs is unique to Isotonix OPC-3, as is the Isotonix delivery system, which enables effective and highly efficient absorption of the OPCs. What is a bioflavonoid? Bioflavonoids are complex organic plant compounds which are found everywhere in the plant kingdom. These compounds are chemically related, yet their chemistry differs from one plant to another. This is obvious from the different colors of fruits and plants, which result from the specific bioflavonoid species they contain. Bioflavonoids have always played an important nutritional role for mankind. A rapidly increasing number of clinical studies show how versatile bioflavonoids support human health. Bioflavonoids, specifically found in OPCs, play a key role for cardiovascular health and vascular integrity. Clinical studies have demonstrated an improved blood flow and enhanced cell vitality. Collagen renewal is accelerated with great effects on firmness of the skin, joint cartilage and connective tissue. And, OPCs help the body's immune response to inflammation. What sets Isotonix OPC-3® apart from other bioflavonoid products? Isotonix OPC-3 offers exclusively those OPC species, which are scientifically proven to be the most potent for human health in the optimal serving size. In addition to being powerful antioxidants, the individual OPCs have been shown in humans to provide myriad health benefits. This science-driven selection of OPCs is unique to Isotonix OPC-3, as is the Isotonix delivery system, which enables effective and highly efficient absorption of the OPCs in just a few minutes. The potent nutrients in combination with the highly effective delivery system make Isotonix OPC-3 the most powerful natural free-radical scavenger, anti-aging and cardiovascular health protecting product ever created. Is Isotonix OPC-3®safe? Yes! OPCs are among the most valuable constituents of a healthy human diet. OPCs have been researched and used for over 30 years throughout How long does it take for me to benefit from Isotonix OPC-3®? Isotonix OPC-3 does not only provide the most potent OPCs available, the unique Isotonix delivery system ensures that the small intestine effectively absorbs the OPCs, which are available in the blood stream within minutes. This is because the OPCs are delivered in liquid form. More importantly the liquid is isotonic, which means it duplicates the environment as it prevails in all our cells and bloodstream in regard to pH, electrolytes, etc. This enables the OPCs to transit into our body without barriers and with a high level of bioavailability. Isotonix OPC-3 immediately begins to work to strengthen blood vessels, which helps maintain your circulation and cell vitality. What is the advantage of taking Isotonix OPC-3® regularly? Many effects of Isotonix OPC-3 start to work after a few servings. Studies with human volunteers have found that particular health merits of OPCs may take a while to develop until they reach full swing. The OPCs enhance the vitality of our cells, and these in turn will fulfill their individual tasks more efficiently. Take, for example, those cells producing collagen. They will continue normal collagen production, and with time skin will become more elastic, and the health of blood vessels and joint cartilage will be supported. OPC is all the while maintaining and enhancing overall cell vitality. Why should everyone take Isotonix OPC-3®? Free-radical damage and oxidative stress are reality. Everyone is subject to it. Free radicals develop as by-products when cells of the body generate energy from burning calories with oxygen. These molecules behave somewhat like hot sparks, which destroy any other cell matter they come into contact with by ridding the other cells of their excess energy. This damage doesn't cause noticeable harm at first, yet it adds up over the years. This process is largely responsible for the aging process itself. If you do not have adequate protection from free radicals, you could appear to age faster and experience health problems you could have avoided. Free radicals have been linked directly to premature aging. OPCs are the most powerful natural, free-radical neutralizers and antioxidants discovered and you get the best of all OPCs in Isotonix OPC-3. This product should be taken for a long healthy life. The regular use every day is vital to keep free radicals in check. Laboratory studies have shown that OPCs are several magnitudes more powerful antioxidants than vitamin C and vitamin E. Isotonix OPC-3® demonstrates benefits and helps strengthen capillaries and support healthy circulation and cell vitality. Can you take Isotonix OPC-3® in soda, juice, coffee, etc., rather than water? It is possible but not recommended. In order to keep the product in an isotonic form and to achieve the maximum delivery speed, it needs to be taken on an empty stomach with 2 oz. of water per capful. To mix the products with anything else slows down the delivery time and may also affect the percentage of uptake. I'm healthy and athletic, why should I take Isotonix OPC-3®? You are fortunate to enjoy good health and be in good shape. Yet, you are vulnerable to the aging process caused by continuous free radical damage as much as anybody else. And, more than that, athletes tend to be exposed to elevated levels of oxidative stress. Remember free radicals develop as by-products during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen over rest during physical activity and this goes along with a burst of extra free radicals. In fact these free radicals are known to also limit performance, as free radicals appear to take their toll also on muscle tissue. Studies on recreational athletes have shown a 20 percent endurance increase with OPCs, as compared to a control group receiving inactive look-alike dummies. Furthermore, Isotonix OPC-3® helps to maintain healthy circulation and cell vitality, and this supports oxygen supply to muscles. Does Isotonix OPC-3® have visible benefits? It is great to take care of your well being, but ultimately we wish other people to notice we are in great shape! As OPCs support collagen production in the skin, an increase of smoothness and elasticity is the natural consequence. Such an effect was indeed objectively measured in women aged 40 years and older. It requires patience until skin cells have renewed significant amounts of collagen to show visible effects. It is compulsory to continuously take Isotonix OPC-3® to keep skin cells at their peak vitality. On a short-term basis, many people notice a fresher-looking skin complexion. This is a result of healthy blood micro-circulation, which helps detoxify the skin and improves the nutrient supply. Does Isotonix OPC-3® have a rejuvenating effect? The damage caused by free radicals adds up with time. A cause for more worry is the fact that your body's own mechanisms to keep free radicals in check decline with increasing age when you need them the most. Suddenly, we find ourselves confronted with some typical age-related problems. And, apparently, some cells of our body are more vulnerable to free radicals than others. Isotonix OPC-3 has the ability to go in and do a knock-out job, cleaning and scavenging the free radicals that feast on cellular energy. What are the proven heart health benefits of OPCs? Initially, OPCs were discovered by the scientist who received the Nobel Prize for the discovery of vitamin C, Dr. Albert Szent-Györgyi. He realized that bleedings as they occur in the disease scurvy result from malnutrition, lacking vitamin C. Szent-Györgyi found that OPCs work in a similar fashion. They strengthen walls of arteries, veins and capillaries. In the past 20 years, scientists discovered that OPCs bear a whole lot more benefits for the cardiovascular system. Epidemiological studies have shown that regular intake of the powerful OPC antioxidants supports a healthy cardiovascular system. Specifically the Pycnogenol® in Isotonix OPC-3® plays a key role, as it stimulates an enzyme in the body to promote healthy nitric oxide (NO) levels. NO is a tiny molecule which serves as a key messenger molecule in the blood stream. It helps smooth muscle surrounding arteries to remain relaxed and maintain healthy blood flow. This benefit has been explicitly demonstrated with Pycnogenol® in two clinical studies. How can Isotonix OPC-3® help my eyes? Loss of eyesight is the disability people fear more than all others. Fortunately, there are specific OPCs, which have been successfully tested for eye health, and these have joined forces in Isotonix OPC-3. Bilberry OPCs were used by pilots of the Royal Air force during World War II, for support of night vision and adjustment to darkness. Pycnogenol® was tested in more than 1,200 people with retinopathy. Pycnogenol was demonstrated to support healthy capillaries in the eye. Isotoonix OPC-3 helps maintain visual health. What exactly is Pycnogenol®? Pycnogenol® is the trademark of Horphag Research (UK) Ltd. for a standardized extract of bark of the French maritime pine tree. Pycnogenol is particularly renowned for its extensive clinical research with more than 120 studies published in peer-reviewed medical journals. The flavonoids species in Pycnogenol are particularly powerful as antioxidants and, furthermore, promotes normal generation of nitric oxide (NO). NO plays a key role in regulating cardiovascular health. NO promotes relaxed arteries, thus supporting the normal diameter. This, in turn, supports healthy blood circulation Pycnogenol has been awarded various U.S.patents. Has this product been reviewed by the Department of Health (DOH)? Yes, this product was reviewed by DOH in This product is not intended to diagnose, treat, cure or prevent any disease. Primary Benefits:
Key Ingredients: Grape Seed Extract 25 mg Grape seed extract are seeds typically from red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). The OPCs are also present in a wide variety of fruits and vegetables, including pine bark (Pycnogenol®) and green tea, where, like grape seed extract, they possess potent antioxidant properties. These antioxidants help protect cells from free-radical damage, and promote cardiovascular health and vision health. Grape seed extract is extremely rich in polyphenols, a compound that’s high in antioxidants. French research on grape seed antioxidant activity and safety is highly credible, because the French government actually categorizes the OPC from grape seed as a pharmaceutical product, like American drugs prescribed by a family doctor. Red Wine Extract 25 mg Red wine is a naturally occurring antioxidant. It occurs naturally in grape vines, roots, seeds and stalks, with its highest concentration in the skins. Red wine is significantly higher in antioxidant properties than in white wine. This brings up the concept of the French-paradox. In the late 1990s, scientists took note of a phenomenon among the French. There were and still are very high rates of heart health in the provinces where residents consistently ate high fat foods and drank red wine. The protective properties of red wine have protected the heart health of the French for years and subsequent scientific studies have proven the fact that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels. In test tube and animal studies, red wine extract helped blood vessels remain open and flexible. Pine Bark Extract 25 mg (Pycnogenol®) Pycnogenol® is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest The extract has three basic properties — it’s a powerful antioxidant, selectively binds to collagen and elastin, and finally, it aids in the production of endothelial nitric oxide which promotes healthy vasolikation of blood vessels. As one of the most potent natural scavenger of free radicals, Pycnogenol® mops-up all kinds of aggressive radicals before they cause any damage via oxidative stress. Its super-antioxidant capabilities help boost the immune system and it strengthens blood vessel walls and capillaries. It helps maintain healthy circulation and cell vitality. Today, Pycnogenol® is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol®’s beneficial effects in cardiovascular health, eye health, skincare, and sports nutrition, among others. Bilberry Extract 25mg Bilberry extract is derived from the leaves and berry like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins. They act as powerful antioxidants. Scientific studies confirm to promote vision and vein health. Bilberry extract strengthens capillaries and arteries. Bilberry is nontoxic. Citrus Extract (Bioflavonoids) 25 mg Bioflavonoids are found in certain plants and act as light filters protecting the delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. Bioflavonoids have been shown to support liver health. This product is not intended to diagnose, treat, cure or prevent any disease. In the News: Grape Seed Extract for Blood Pressure?
SOURCES: American Chemical Society National Meeting & Exposition,
Scientific Studies: o Bertelli AA, Giovanninni L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61–3. o Petri G, Krawczyk U, Kery A. Spectrophotometric and chromatographic investigation of bilberry anthocyanins for qualification purposes. Acta Pharm Hung. 1994 Jul;64(4):117-22. o Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol 1996;27:363–6. o Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163–82. o Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997;275:218–20. o Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Rohdewald, P. Pycnoge0nol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998. o Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002. o Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999. o Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997. o Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993. o Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004. o Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004. o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994. o Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000. o Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000. o Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY o Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh o Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000. o Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. o Huynh HT, Teel RW. Effects of pycnogenol on the microsomal metabolism of the tobacco-specific nitrosamine NNK as a function of age. Cancer Lett. 1998; 132:135-139. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002. o Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001. o Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996. o Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994. o Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998. o Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000. o Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY o Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998. o Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh o Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997. o Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994. o Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998. o Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000. o Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY o Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998. o Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh o Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997. o Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004. o Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003. o Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004. o Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004. o Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999. o Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002. o Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999. o Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004. o Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review. o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994. o Sato M, Maulik G, Ray PS, et al. Cardioprotective effects of grape seed proanthocyanidins against ischemic reperfusion injury. J Mol Cell Cardiol. 1999; 31:1289-1297 o Yamakoshi J, Kataoka S, Koga T, Ariga T. Proanthocyanidin-rich extract from grape seed attenuates the development of aortic atherosclerosis in cholesterol-fed rabbis. Atherosclerosis. 1999; 142:139-149. o Araghi-Niknam M, Hosseini S, Larson D, Rohdewald P, Watson RR. Pine bark extract reduces platelet aggregation. Integr. Med..2000 Mar 21;2(2):73-77 o Miztuani K, Ikeda K, Kawai Y, Yamori Y. Extract of wine phenolics improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats (SHRSP). J Nutr Sci Vitaminol ( What Makes This Product Unique? Isotonix OPC-3® is an isotonic-capable dietary supplement that is made from a combination of grape seed, red wine and pine bark extracts. To clarify, when speaking of isotonic supplements, we mean the way dietary supplements are absorbed by your body. Taken orally, Isotonic supplements bear chemical resemblance to your own tears, intravenous fluids and plasma, so in turn, your bodily systems welcome the assimilation and integration of this product. Next, Isotonix OPC-3 offers exclusive OPC ingredients, which are scientifically proven to be the most potent in antioxidant activity, which is vital for human health. In addition to being powerful antioxidants, the individual OPCs in Isotonix OPC-3 have been shown in humans to provide benefits for many various specific health concerns. This science-driven selection makes Isotonix OPC-3 the most powerful, natural free-radical scavenger, anti-aging and cardiovascular health protecting product ever created. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (or complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be up to many times more powerful than Vitamin C and Vitamin E. The purest and best researched OPCs chosen for Isotonix OPC-3 are prepared from grapes, bilberries, Pycnogenol® from pine bark and citrus fruit. At the top of the ingredient list, the grape seed extract is a superior source of OPC, containing 92 percent of active ingredients with pine bark containing 84 percent of active OPC ingredients. The red wine extract contains flavonoids called leucocyanidins from the skin of red grapes. These are the three best sources of oligometric proanthocyanidins available and are all contained in Isotonix OPC-3. Over 20,000 different flavonoids have been discovered, of which a select few are water-soluble and easily absorbed by the body. The bioflavonoids found in Isotonix OPC-3 are the most potent and bio-available. These are called Pycnogenol®, a name coined by scientist Dr. Jacques Masquelier, a professor at the University of Bordeaux, France. Isotonix OPC-3 also contains two additional sources of bioflavonoids: bilberry and citrus extracts. Isotonix OPC-3 is superior to any other OPC supplement in total polyphenol content, active ingredients quality and isotonic capability. Isotonix OPC-3 is the most powerful free radical neutralizer available. Isotonix OPC-3 has a pleasant, natural grape flavor and is a vegetarian product. This product is not intended to diagnose, treat, cure or prevent any disease. Frequently Asked Questions: What is Isotonix OPC-3®? Isotonix OPC-3 is a natural food supplement that bears as active ingredients the most powerful bioflavonoids currently known to research scientists. These bioflavonoids are scientifically termed "oligomeric proanthocyanidins", commonly abbreviated OPC. The purest and best-researched OPCs chosen for Isotonix OPC-3 are prepared from grapes, bilberries, Pycnogenol from pine bark and citrus fruit. They are rated the highest in terms of total polyphenol content. As well as being powerful antioxidants, scavenging free radicals, the individual OPCs are known to have special merits for certain parts of the body. These super powerful bioflavanoids are considered many times more potent than vitamins C and E as free-radical scavengers. They do, however, work with both vitamin C and E to form an effective antioxidant network within the membranes and cytoplasm of cells. It strengthens capillary, arteries, veins and promotes healthy circulation, making it easier for cells to assimilate food. This combination of potent OPCs is unique to Isotonix OPC-3, as is the Isotonix delivery system, which enables effective and highly efficient absorption of the OPCs. What is a bioflavonoid? Bioflavonoids are complex organic plant compounds which are found everywhere in the plant kingdom. These compounds are chemically related, yet their chemistry differs from one plant to another. This is obvious from the different colors of fruits and plants, which result from the specific bioflavonoid species they contain. Bioflavonoids have always played an important nutritional role for mankind. A rapidly increasing number of clinical studies show how versatile bioflavonoids support human health. Bioflavonoids, specifically found in OPCs, play a key role for cardiovascular health and vascular integrity. Clinical studies have demonstrated an improved blood flow and enhanced cell vitality. Collagen renewal is accelerated with great effects on firmness of the skin, joint cartilage and connective tissue. And, OPCs help the body's immune response to inflammation. What sets Isotonix OPC-3® apart from other bioflavonoid products? Isotonix OPC-3 offers exclusively those OPC species, which are scientifically proven to be the most potent for human health in the optimal serving size. In addition to being powerful antioxidants, the individual OPCs have been shown in humans to provide myriad health benefits. This science-driven selection of OPCs is unique to Isotonix OPC-3, as is the Isotonix delivery system, which enables effective and highly efficient absorption of the OPCs in just a few minutes. The potent nutrients in combination with the highly effective delivery system make Isotonix OPC-3 the most powerful natural free-radical scavenger, anti-aging and cardiovascular health protecting product ever created. Is Isotonix OPC-3®safe? Yes! OPCs are among the most valuable constituents of a healthy human diet. OPCs have been researched and used for over 30 years throughout How long does it take for me to benefit from Isotonix OPC-3®? Isotonix OPC-3 does not only provide the most potent OPCs available, the unique Isotonix delivery system ensures that the small intestine effectively absorbs the OPCs, which are available in the blood stream within minutes. This is because the OPCs are delivered in liquid form. More importantly the liquid is isotonic, which means it duplicates the environment as it prevails in all our cells and bloodstream in regard to pH, electrolytes, etc. This enables the OPCs to transit into our body without barriers and with a high level of bioavailability. Isotonix OPC-3 immediately begins to work to strengthen blood vessels, which helps maintain your circulation and cell vitality. What is the advantage of taking Isotonix OPC-3® regularly? Many effects of Isotonix OPC-3 start to work after a few servings. Studies with human volunteers have found that particular health merits of OPCs may take a while to develop until they reach full swing. The OPCs enhance the vitality of our cells, and these in turn will fulfill their individual tasks more efficiently. Take, for example, those cells producing collagen. They will continue normal collagen production, and with time skin will become more elastic, and the health of blood vessels and joint cartilage will be supported. OPC is all the while maintaining and enhancing overall cell vitality. Why should everyone take Isotonix OPC-3®? Free-radical damage and oxidative stress are reality. Everyone is subject to it. Free radicals develop as by-products when cells of the body generate energy from burning calories with oxygen. These molecules behave somewhat like hot sparks, which destroy any other cell matter they come into contact with by ridding the other cells of their excess energy. This damage doesn't cause noticeable harm at first, yet it adds up over the years. This process is largely responsible for the aging process itself. If you do not have adequate protection from free radicals, you could appear to age faster and experience health problems you could have avoided. Free radicals have been linked directly to premature aging. OPCs are the most powerful natural, free-radical neutralizers and antioxidants discovered and you get the best of all OPCs in Isotonix OPC-3. This product should be taken for a long healthy life. The regular use every day is vital to keep free radicals in check. Laboratory studies have shown that OPCs are several magnitudes more powerful antioxidants than vitamin C and vitamin E. Isotonix OPC-3® demonstrates benefits and helps strengthen capillaries and support healthy circulation and cell vitality. Can you take Isotonix OPC-3® in soda, juice, coffee, etc., rather than water? It is possible but not recommended. In order to keep the product in an isotonic form and to achieve the maximum delivery speed, it needs to be taken on an empty stomach with 2 oz. of water per capful. To mix the products with anything else slows down the delivery time and may also affect the percentage of uptake. I'm healthy and athletic, why should I take Isotonix OPC-3®? You are fortunate to enjoy good health and be in good shape. Yet, you are vulnerable to the aging process caused by continuous free radical damage as much as anybody else. And, more than that, athletes tend to be exposed to elevated levels of oxidative stress. Remember free radicals develop as by-products during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen over rest during physical activity and this goes along with a burst of extra free radicals. In fact these free radicals are known to also limit performance, as free radicals appear to take their toll also on muscle tissue. Studies on recreational athletes have shown a 20 percent endurance increase with OPCs, as compared to a control group receiving inactive look-alike dummies. Furthermore, Isotonix OPC-3® helps to maintain healthy circulation and cell vitality, and this supports oxygen supply to muscles. Does Isotonix OPC-3® have visible benefits? It is great to take care of your well being, but ultimately we wish other people to notice we are in great shape! As OPCs support collagen production in the skin, an increase of smoothness and elasticity is the natural consequence. Such an effect was indeed objectively measured in women aged 40 years and older. It requires patience until skin cells have renewed significant amounts of collagen to show visible effects. It is compulsory to continuously take Isotonix OPC-3® to keep skin cells at their peak vitality. On a short-term basis, many people notice a fresher-looking skin complexion. This is a result of healthy blood micro-circulation, which helps detoxify the skin and improves the nutrient supply. Does Isotonix OPC-3® have a rejuvenating effect? The damage caused by free radicals adds up with time. A cause for more worry is the fact that your body's own mechanisms to keep free radicals in check decline with increasing age when you need them the most. Suddenly, we find ourselves confronted with some typical age-related problems. And, apparently, some cells of our body are more vulnerable to free radicals than others. Isotonix OPC-3 has the ability to go in and do a knock-out job, cleaning and scavenging the free radicals that feast on cellular energy. What are the proven heart health benefits of OPCs? Initially, OPCs were discovered by the scientist who received the Nobel Prize for the discovery of vitamin C, Dr. Albert Szent-Györgyi. He realized that bleedings as they occur in the disease scurvy result from malnutrition, lacking vitamin C. Szent-Györgyi found that OPCs work in a similar fashion. They strengthen walls of arteries, veins and capillaries. In the past 20 years, scientists discovered that OPCs bear a whole lot more benefits for the cardiovascular system. Epidemiological studies have shown that regular intake of the powerful OPC antioxidants supports a healthy cardiovascular system. Specifically the Pycnogenol® in Isotonix OPC-3® plays a key role, as it stimulates an enzyme in the body to promote healthy nitric oxide (NO) levels. NO is a tiny molecule which serves as a key messenger molecule in the blood stream. It helps smooth muscle surrounding arteries to remain relaxed and maintain healthy blood flow. This benefit has been explicitly demonstrated with Pycnogenol® in two clinical studies. How can Isotonix OPC-3® help my eyes? Loss of eyesight is the disability people fear more than all others. Fortunately, there are specific OPCs, which have been successfully tested for eye health, and these have joined forces in Isotonix OPC-3. Bilberry OPCs were used by pilots of the Royal Air force during World War II, for support of night vision and adjustment to darkness. Pycnogenol® was tested in more than 1,200 people with retinopathy. Pycnogenol was demonstrated to support healthy capillaries in the eye. Isotoonix OPC-3 helps maintain visual health. What exactly is Pycnogenol®? Pycnogenol® is the trademark of Horphag Research (UK) Ltd. for a standardized extract of bark of the French maritime pine tree. Pycnogenol is particularly renowned for its extensive clinical research with more than 120 studies published in peer-reviewed medical journals. The flavonoids species in Pycnogenol are particularly powerful as antioxidants and, furthermore, promotes normal generation of nitric oxide (NO). NO plays a key role in regulating cardiovascular health. NO promotes relaxed arteries, thus supporting the normal diameter. This, in turn, supports healthy blood circulation Pycnogenol has been awarded various U.S.patents. Has this product been reviewed by the Department of Health (DOH)? Yes, this product was reviewed by DOH in This product is not intended to diagnose, treat, cure or prevent any disease. |
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