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Primary Benefits*:
§ CoQ10 concentrations naturally diminish with age and deficiency has been associated with certain health concerns; the body’s ability to synthesize normal amounts of CoQ10 is inhibited by one class of cholesterol-lowering drugs § CoQ10 is a fat-soluble coenzyme, which is a substance that is necessary to, or supports the action of an enzyme § CoQ10 is a potent antioxidant that is known to scavenge oxygen radicals in the mitochondria during oxidative phosphorylation § CoQ10 is essential for the production of energy in every cell of the human body; CoQ10 is a component of the electron-transport that is required to manufacture adenosine triphosphate (ATP) § CoQ10 is known as “ubiquinone”, a substance that is similar in structure to a vitamin and is found mainly in mitochondria throughout the body § CoQ10 resides in the membranes of the cells’ mitochondria
These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease. Key Ingredients: Coenzyme Q10 (CoQSol-CF™) 102 mg Coenzyme Q10 belongs to a family of substances called ubiquinones, and is a water-insoluble, wax-like substance that is part of the respiratory chain. Since it is a coenzyme, it is necessary to support the action of an enzyme, and it has a similar structure to vitamin K. CoQ10 is found in each of the 50-75 trillion cells throughout the body, except for mature red blood cells. It has a multitude of health benefits at the cellular level, in the cardiovascular system, and with the body’s metabolism. It serves to revitalize and energize the body’s cells and immune system and contributes to increases in stamina and endurance by fueling the body’s energy production (ATP) cycle. It is beneficial to the cardiovascular system because it helps to protect the heart, maintain normal blood pressure, and promotes mental alertness and brain activity.* The mechanism of action of supplemental coenzyme Q10 has yet to be clarified, and is a matter of much speculation. However, much is known about the biochemistry of CoQ10. Coenzyme Q10 is a two-part compound that is composed of a long, fat-soluble isoprenoid tail that anchors the molecule in the inner membrane of the mitochondria, and quinine that is capable of accepting and transferring electrons through a portion of the respiratory chain. The “Q” stands for quinine and the “10” stands for the number of isoprenoid units in the tail portion of the molecule. It is synthesized in the cells, and is involved in electron transport and energy production in mitochondria. In the cellular system, it functions to generate energy from oxygen, in the form of ATP, for bodily processes. It serves as a free radical scavenger and an antioxidant. The antioxidant activity in the mitochondria and cell membranes promotes the stability and health of lipid membranes. Combining CoQ10 with vitamin E generates a synergistic antioxidant effect on lipoprotein and spares the vitamin E.* Coenzyme Q10 can be found in spinach, broccoli, nuts, soy, organ and muscle meats, and fish. In 1977, a Japanese company succeeded in synthesizing coenzyme Q10, which made the nutrient available to the world. CoQ10 is absorbed in the small intestine and a steady-state concentration can be attained in the body in five to six weeks. In the body, it is found in the highest concentration in the cells of the heart, liver, kidney and pancreas. The liver produces small amounts of CoQ10, and then it is distributed to the rest of the body. Vitamin E (d-alpha-Tocopherol): The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup) and there are trace amounts in corn oil and soybean oil. Vitamin E is actually a family of related compounds called tocopherols and tocotrienols. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. The natural form of alpha-tocopherol is known as "d-alpha tocopherol." The synthetic "dl-" form is the most common form found in dietary supplements. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content.* The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It also promotes the normal healing of wounds and is known to promote cardiovascular health. Vitamin E is one of the most powerful fat-soluble antioxidants in the body. Vitamin E protects cell membranes from free radical damage.*
These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease. In the News: Body's Energy-Producing Component May Serve As an Antioxidant
A Supplement for Your Heart Can the supplement coenzyme Q10 help my heart problems? May 22, 2000 Coenzyme Q10 May Slow Parkinson's High Doses of Popular Supplement Delays Deterioration
More support for CoQ10's benefits for heart health Nutraingredients.com Women on the pill could benefit from Q10, vit E Nutraingredients.com Coenzyme Q10: It May Just Be the Miracle Vitamin of the 1990s Coenzyme Q10 2005 - www.aafp.org CoQ10 boosts vitamin E's anti-inflammatory action
These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease. Scientific Studies: ° Kagan, V, et al. Coenzyme Q: Its role in scavenging and generation of radicals in membranes. In Handbook of Antioxidants, eds. Enrique Cadenas and Lester Packer, New York, Marcel Dekker, Inc., 1996, pp. 157-201. ° Littarru, G.P. et al. Clinical aspects of coenzyme Q: Improvement of cellular bioenergetics or antioxidant protection? In Handbook of Antioxidants, eds. ° Greenberg, S. and Frishman, W.H. Coenzyme Q10: A new drug for cardiovascular disease. Journal of Clinical Pharmacology 30: 596-608, 1990. ° Chello, M, et al. Protection of coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Annals of Thoracic Surgery 58: 1427-1432, 1994. ° Lansjoen, P.H. et al. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind crossover trial with coenzyme Q10. Proceedings of the National ° Stryer, L. Biochemistry, 2nd ed. New York, W.H. Freeman and Company, 1981. ° Firstein, R. The Nutraceutical Revolution. ° Frei, B, et al. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proceedings of the National ° Hanaki, Y. et al. Ratio of low-density lipoprotein cholesterol to ubiquinone as a coronary risk factor: New England Journal of Medicine, 325: 814-815, 1991. ° Singh R.B. and Singh M.M. Effects of coenzyme Q10 in new indications with antioxidant vitamin deficiency. Journal of Nutritional and Environmental Medicine 9: 223-228, 1999. ° Greenburg S. and Frishman W. Coenzyme Q10: A new drug from myocardial ischemia? Medical Clinics of ° Langsjoen, P.H. et al. Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy. International Journal of Tissue Reactions 12: 163-168, 1990. ° Digiesi, V. et al. Mechanism of action of coenzyme Q10 in essential hypertension. Current Therapy and Research 51: 668-672, 1992. ° Sunamori, M. et al. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovascular Drugs and Therapy 5: 297-300, 1991. ° Langsjoen, P.H. et al. A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10. International Journal of Tissue Reactions 12: 169-71, 199. ° Stocker, R. et al. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proceedings of the National ° Shi, H. and Noguchi, N. Dynamics of antioxidant action of ubiquinol: A reappraisal. Biofactors 9: 141-148, 1999. ° Folkers, K. et al. Effect of coenzyme Q10 on serum levels of creatine phosphokinase in preclinical muscular dystrophy. Proceedings of the National ° Folkers, K. et al. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proceedings of the National ° Chen Y.F., Lin Y.T. and Wu S.C. Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest. Journal of Thoracic and Cardiovascular Surgery 107: 242-247, 1994. ° Murray, M.T. Encyclopedia of Natural Medicine, ° Folkers, K et al. The activities of coenzyme and vitamin B6 for immune responses. Biochemical and Biophysical Research Communications 193: 88-92, 1993. ° Folkers, K et al. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS-related complex. Biochemical and Biophysical Research Communications 176: 25. ° Lockwood, K. et al. Partial and complete regression of breast cancer in patients in relation to dosage of Coenzyme Q10. Biomedical and Biophysical Research Communications 199: 1504-1508, 1994. ° Nakamura, R. et al. Study of Co Q10-enzymes in gingival tissues from patients with periodontal disease and evidence for a deficiency of coenzyme Q10. Proceedings of the National ° Littarru, G.P. et al. Deficiency of coenzyme Q10 in gingival tissue from patients with periodontal disease. Proceedings of National
These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease. What Makes This Product Unique? Poor cardiovascular health is one of the leading causes of death and illness in the All cellular functions depend upon the production of adenosine triphosphate (ATP). ATP is a molecule with three high-energy phosphate bonds, which exist in all of our cells. It is the primary energy source for many metabolic processes. Coenzyme Q10 is essential to the ATP production process, and the heart has a high metabolic demand, which is why normal levels of CoQ10 are associated with good cardiovascular health. As part of the energy production process CoQ10 exists in the inner mitochondrial membrane as part of the electron transport chain. CoQ10 transports the electrons and protons through the membranes to make the energy production process possible. The lysosomal membranes that separate digestive enzymes from the rest of the cell contain relatively high concentrations of Coenzyme Q10. Recent research suggests that Coenzyme Q10 plays an important role in the transport of protons across lysosomal membranes to maintain the optimal pH for cellular recycling. Within a cell, it serves as a carrier of electrons in the electron transport chain, neutralizes free radicals, and helps maintain the integrity of the mitochondrial membrane. Throughout the aging process, the body’s ability to synthesize Coenzyme Q10 begins to decline. Sometimes this is due to stress or infections, but the main challenge is a poor diet. Heart Health™ Advanced Co-Q10 is a blend of CoQSol-CF™ and vitamin E, designed to promote overall cardiovascular health. CoQSol-CF™ is a unique, patent-pending formula of CoQ10, food grade d-limonene (which serves as a non-polar, organic solvent), and tocopherol (vitamin E). This combination creates a liquid, crystal-free solution of CoQ10 that provides enhanced bioavailability. By improving dissolution, absorption is enhanced. Heart Health™ Advanced Co-Q10 helps maintain normal blood pressure, helps maintain healthy cholesterol levels, provides antioxidant protection for the cardiovascular system, helps maintain heart muscle strength, helps maintain cognitive health and promotes cellular energy production.*
These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease. Frequently Asked Questions: What type of vitamin E is in Advanced Coenzyme Q10? The natural form of vitamin E, d-Alpha-Tocopherol, is in Advance Coenzyme Q10. It is far superior to synthetic in terms of retention in the body and absorption. If my body makes CoQ10, why should I take a supplement? What is the recommended serving size of Coenzyme Q10? Coenzyme Q10 has been used in maintenance servings of 30-60 mg, but can go up to Is there a certain time I should take CoQ10? Coenzyme Q10 should be taken with a meal containing some fat. However, taking it in combination with soy or vegetable oil substantially enhances it absorption. Is it okay to take a CoQ10 supplement while pregnant or nursing? No. The safety of coenzyme Q10 has not been established in pregnancy and lactation. Is it safe to take CoQ10? Yes, it is safe to take CoQ10; it does not produce any toxic side effects when ingested by humans or animals. It is listed in the 42nd edition of the Physicians Desk Reference as replacement therapy for a nutrient, and no adverse reactions are listed.
These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.
These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease. Primary Benefits*:
§ CoQ10 concentrations naturally diminish with age and deficiency has been associated with certain health concerns; the body’s ability to synthesize normal amounts of CoQ10 is inhibited by one class of cholesterol-lowering drugs § CoQ10 is a fat-soluble coenzyme, which is a substance that is necessary to, or supports the action of an enzyme § CoQ10 is a potent antioxidant that is known to scavenge oxygen radicals in the mitochondria during oxidative phosphorylation § CoQ10 is essential for the production of energy in every cell of the human body; CoQ10 is a component of the electron-transport that is required to manufacture adenosine triphosphate (ATP) § CoQ10 is known as “ubiquinone”, a substance that is similar in structure to a vitamin and is found mainly in mitochondria throughout the body § CoQ10 resides in the membranes of the cells’ mitochondria
Key Ingredients: Coenzyme Q10 (CoQSol-CF™) 102 mg Coenzyme Q10 belongs to a family of substances called ubiquinones, and is a water-insoluble, wax-like substance that is part of the respiratory chain. Since it is a coenzyme, it is necessary to support the action of an enzyme, and it has a similar structure to vitamin K. CoQ10 is found in each of the 50-75 trillion cells throughout the body, except for mature red blood cells. It has a multitude of health benefits at the cellular level, in the cardiovascular system, and with the body’s metabolism. It serves to revitalize and energize the body’s cells and immune system and contributes to increases in stamina and endurance by fueling the body’s energy production (ATP) cycle. It is beneficial to the cardiovascular system because it helps to protect the heart, maintain normal blood pressure, and promotes mental alertness and brain activity.* The mechanism of action of supplemental coenzyme Q10 has yet to be clarified, and is a matter of much speculation. However, much is known about the biochemistry of CoQ10. Coenzyme Q10 is a two-part compound that is composed of a long, fat-soluble isoprenoid tail that anchors the molecule in the inner membrane of the mitochondria, and quinine that is capable of accepting and transferring electrons through a portion of the respiratory chain. The “Q” stands for quinine and the “10” stands for the number of isoprenoid units in the tail portion of the molecule. It is synthesized in the cells, and is involved in electron transport and energy production in mitochondria. In the cellular system, it functions to generate energy from oxygen, in the form of ATP, for bodily processes. It serves as a free radical scavenger and an antioxidant. The antioxidant activity in the mitochondria and cell membranes promotes the stability and health of lipid membranes. Combining CoQ10 with vitamin E generates a synergistic antioxidant effect on lipoprotein and spares the vitamin E.* Coenzyme Q10 can be found in spinach, broccoli, nuts, soy, organ and muscle meats, and fish. In 1977, a Japanese company succeeded in synthesizing coenzyme Q10, which made the nutrient available to the world. CoQ10 is absorbed in the small intestine and a steady-state concentration can be attained in the body in five to six weeks. In the body, it is found in the highest concentration in the cells of the heart, liver, kidney and pancreas. The liver produces small amounts of CoQ10, and then it is distributed to the rest of the body. Vitamin E (d-alpha-Tocopherol): The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup) and there are trace amounts in corn oil and soybean oil. Vitamin E is actually a family of related compounds called tocopherols and tocotrienols. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. The natural form of alpha-tocopherol is known as "d-alpha tocopherol." The synthetic "dl-" form is the most common form found in dietary supplements. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content.* The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It also promotes the normal healing of wounds and is known to promote cardiovascular health. Vitamin E is one of the most powerful fat-soluble antioxidants in the body. Vitamin E protects cell membranes from free radical damage.*
In the News: Body's Energy-Producing Component May Serve As an Antioxidant
A Supplement for Your Heart Can the supplement coenzyme Q10 help my heart problems? May 22, 2000 Coenzyme Q10 May Slow Parkinson's High Doses of Popular Supplement Delays Deterioration
More support for CoQ10's benefits for heart health Nutraingredients.com Women on the pill could benefit from Q10, vit E Nutraingredients.com Coenzyme Q10: It May Just Be the Miracle Vitamin of the 1990s Coenzyme Q10 2005 - www.aafp.org CoQ10 boosts vitamin E's anti-inflammatory action Scientific Studies: ° Kagan, V, et al. Coenzyme Q: Its role in scavenging and generation of radicals in membranes. In Handbook of Antioxidants, eds. Enrique Cadenas and Lester Packer, New York, Marcel Dekker, Inc., 1996, pp. 157-201. ° Littarru, G.P. et al. Clinical aspects of coenzyme Q: Improvement of cellular bioenergetics or antioxidant protection? In Handbook of Antioxidants, eds. ° Greenberg, S. and Frishman, W.H. Coenzyme Q10: A new drug for cardiovascular disease. Journal of Clinical Pharmacology 30: 596-608, 1990. ° Chello, M, et al. Protection of coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Annals of Thoracic Surgery 58: 1427-1432, 1994. ° Lansjoen, P.H. et al. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind crossover trial with coenzyme Q10. Proceedings of the National ° Stryer, L. Biochemistry, 2nd ed. New York, W.H. Freeman and Company, 1981. ° Firstein, R. The Nutraceutical Revolution. ° Frei, B, et al. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proceedings of the National ° Hanaki, Y. et al. Ratio of low-density lipoprotein cholesterol to ubiquinone as a coronary risk factor: New England Journal of Medicine, 325: 814-815, 1991. ° Singh R.B. and Singh M.M. Effects of coenzyme Q10 in new indications with antioxidant vitamin deficiency. Journal of Nutritional and Environmental Medicine 9: 223-228, 1999. ° Greenburg S. and Frishman W. Coenzyme Q10: A new drug from myocardial ischemia? Medical Clinics of ° Langsjoen, P.H. et al. Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy. International Journal of Tissue Reactions 12: 163-168, 1990. ° Digiesi, V. et al. Mechanism of action of coenzyme Q10 in essential hypertension. Current Therapy and Research 51: 668-672, 1992. ° Sunamori, M. et al. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovascular Drugs and Therapy 5: 297-300, 1991. ° Langsjoen, P.H. et al. A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10. International Journal of Tissue Reactions 12: 169-71, 199. ° Stocker, R. et al. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proceedings of the National ° Shi, H. and Noguchi, N. Dynamics of antioxidant action of ubiquinol: A reappraisal. Biofactors 9: 141-148, 1999. ° Folkers, K. et al. Effect of coenzyme Q10 on serum levels of creatine phosphokinase in preclinical muscular dystrophy. Proceedings of the National ° Folkers, K. et al. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proceedings of the National ° Chen Y.F., Lin Y.T. and Wu S.C. Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest. Journal of Thoracic and Cardiovascular Surgery 107: 242-247, 1994. ° Murray, M.T. Encyclopedia of Natural Medicine, ° Folkers, K et al. The activities of coenzyme and vitamin B6 for immune responses. Biochemical and Biophysical Research Communications 193: 88-92, 1993. ° Folkers, K et al. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS-related complex. Biochemical and Biophysical Research Communications 176: 25. ° Lockwood, K. et al. Partial and complete regression of breast cancer in patients in relation to dosage of Coenzyme Q10. Biomedical and Biophysical Research Communications 199: 1504-1508, 1994. ° Nakamura, R. et al. Study of Co Q10-enzymes in gingival tissues from patients with periodontal disease and evidence for a deficiency of coenzyme Q10. Proceedings of the National ° Littarru, G.P. et al. Deficiency of coenzyme Q10 in gingival tissue from patients with periodontal disease. Proceedings of National
What Makes This Product Unique? Poor cardiovascular health is one of the leading causes of death and illness in the All cellular functions depend upon the production of adenosine triphosphate (ATP). ATP is a molecule with three high-energy phosphate bonds, which exist in all of our cells. It is the primary energy source for many metabolic processes. Coenzyme Q10 is essential to the ATP production process, and the heart has a high metabolic demand, which is why normal levels of CoQ10 are associated with good cardiovascular health. As part of the energy production process CoQ10 exists in the inner mitochondrial membrane as part of the electron transport chain. CoQ10 transports the electrons and protons through the membranes to make the energy production process possible. The lysosomal membranes that separate digestive enzymes from the rest of the cell contain relatively high concentrations of Coenzyme Q10. Recent research suggests that Coenzyme Q10 plays an important role in the transport of protons across lysosomal membranes to maintain the optimal pH for cellular recycling. Within a cell, it serves as a carrier of electrons in the electron transport chain, neutralizes free radicals, and helps maintain the integrity of the mitochondrial membrane. Throughout the aging process, the body’s ability to synthesize Coenzyme Q10 begins to decline. Sometimes this is due to stress or infections, but the main challenge is a poor diet. Heart Health™ Advanced Co-Q10 is a blend of CoQSol-CF™ and vitamin E, designed to promote overall cardiovascular health. CoQSol-CF™ is a unique, patent-pending formula of CoQ10, food grade d-limonene (which serves as a non-polar, organic solvent), and tocopherol (vitamin E). This combination creates a liquid, crystal-free solution of CoQ10 that provides enhanced bioavailability. By improving dissolution, absorption is enhanced. Heart Health™ Advanced Co-Q10 helps maintain normal blood pressure, helps maintain healthy cholesterol levels, provides antioxidant protection for the cardiovascular system, helps maintain heart muscle strength, helps maintain cognitive health and promotes cellular energy production.* Frequently Asked Questions: What type of vitamin E is in Advanced Coenzyme Q10? The natural form of vitamin E, d-Alpha-Tocopherol, is in Advance Coenzyme Q10. It is far superior to synthetic in terms of retention in the body and absorption. If my body makes CoQ10, why should I take a supplement? What is the recommended serving size of Coenzyme Q10? Coenzyme Q10 has been used in maintenance servings of 30-60 mg, but can go up to Is there a certain time I should take CoQ10? Coenzyme Q10 should be taken with a meal containing some fat. However, taking it in combination with soy or vegetable oil substantially enhances it absorption. Is it okay to take a CoQ10 supplement while pregnant or nursing? No. The safety of coenzyme Q10 has not been established in pregnancy and lactation. Is it safe to take CoQ10? Yes, it is safe to take CoQ10; it does not produce any toxic side effects when ingested by humans or animals. It is listed in the 42nd edition of the Physicians Desk Reference as replacement therapy for a nutrient, and no adverse reactions are listed.
These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.
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