Glucosatrin® Bone & Joint Health

Primary Benefits of Glucosatrin® Bone and Joint Formula*:

·         Helps regulate the immune response to stimuli

·         Promotes skeletal health

·         Helps maintain strong bones

·         Promotes normal movement and flexibility of joints

·         Promotes the retention and normal regeneration of cartilage

·         Helps maintain joint comfort

·         Promotes joint health and flexibility as you age

·         Supports normal, healthy 5-LOX and COX-2 levels

Key Ingredients Found In Glucosatrin® Bone and Joint Formula:

Glucosamine
Glucosamine is an aminopolysaccharide (a combination of the amino acid — glutamine and a sugar — glucose). Glucosamine is concentrated in joint cartilage where it is incorporated in longer chains known as glycosaminoglycans and finally into very large structures known as proteoglycans. Glucosamine is naturally produced by the body and is a key component of cartilage. Glucosamine supports healthy joint function and promotes the normal production of synovial fluid, which lubricates your joints and regenerates cartilage. 

There are numerous European studies showing a clear benefit of glucosamine supplements for promoting joint health.

Vitamin D3
Regular sunlight exposure is the primary means of attaining Vitamin D. Food sources of vitamin D include cod liver oil, fatty fish like salmon, egg yokes, liver and Vitamin D-fortified milk.

Vitamin D supports the absorption of calcium and phosphorus and promotes the production of several proteins involved in calcium absorption and storage.  Vitamin D works with calcium to promote hard, strong bones.  It promotes the normal transport of calcium out of the osteoblasts into the extra-cellular fluid and in the kidneys and promotes calcium and phosphate re-uptake by renal tubules.  Vitamin D also promotes the absorption of dietary calcium and phosphate uptake by the intestinal epithelium.

Vitamin C
Around 90 percent of vitamin C in the typical diet comes from fresh fruits and vegetables. Some of the best sources are peppers (sweet green and red peppers and hot red and green chili peppers), citrus fruits and juices, brussels sprouts, cauliflower, cabbage, kale, collards, mustard greens, broccoli, spinach and strawberries. Vitamin C is an antioxidant that promotes the normal growth and repair of tissue and supports adrenal gland function and gum health. It enhances immune function, supports the normal absorption of iron and supports cardiovascular health. It has been shown to operate as a signaling molecule to support the normal regulation of the synaptic efficiency of neurotransmitters dopamine and glutamic acid.

Manganese
The richest dietary sources of manganese include whole grains, nuts, leafy vegetables and teas. The efficiency of the absorption of manganese is low — around five percent. It may also help to alleviate some PMS symptoms and mood swings.

Low levels of manganese in the body can contribute to weakness. Manganese deficiencies are considered rare since it is relatively easy to obtain adequate amounts of manganese through the diet. Interestingly, some experts estimate that as many as 37 percent of Americans do not get the recommended daily amounts of manganese in their diet. This may be due to the fact that whole grains are a major source of dietary manganese, and many Americans consume refined grains more often than whole grains. Refined grains provide only half the amount of manganese as whole grains.

Additional benefits of manganese include: supporting calcium absorption, helping to maintain healthy blood pressure, promoting the normal formation of bones, supporting fat and carbohydrate metabolism and promoting the normal formation of sex hormones.

Boswellia Resin
The boswellia plant produces a resin that has been used in traditional Indian medicine as a support for joint health. The plant has a long history of safe and effective use for promoting joint comfort.  It supports normal mobility.

Boswellia Resin contains active boswellic acids which have been shown to support healthy cartilage and joint health.

Scutellaria Root
Scutellaria is also called Scullcap and is a member of the mint family. There are more than 100 related species of scutellaria throughout North America, Europe and China. In traditional Chinese medicine, scutellaria has been used for supporting healthy joints.

Three bioactive flavonoids — baicalin, baicalein and wogonin — have been extracted from scutellaria and are thought to contribute to the major activities of the plant. All three flavonoids have been shown to support healthy joints.

Oleanolic Acid
Oleanolic acid is found in numerous herbs used in Chinese and Ayurvedic medicine. Oleanolic Acid is isolated from the seeds of the plant Randia dumetornm (Rubiaceae). The compound promotes healthy joints.

Hops Extract
Hops (Humulus lupulus) have long been associated with beer and ale, but the beverage originally called ale in English was made from fermented malt only and contained no Hops. Although hops’ confirmed value lies in its use for sleep aid, this herb has also been used to stimulate the appetite, support the flow of digestive juices and promote bone health. 

Scientific Studies Which Support Glucosatrin^® Bone and Joint Formula:

·         Ammon HP. Salai Guggai - Boswellia serrata: from herbal medicine to a non-redox inhibitor of leukotriene biosynthesis. Eur J Med Res 1:369-70, 1996.

·         Anonymous. Boswellia seratta. Alternative Medicine Review 3:306-7, 1998.

·         Bowman BA and Russell RM. Present Knowledge in Nutrition, International Life Sciences Institute, 2001.

·         Cheryl Hawk, D.C.  Manganese Deficiency and its Role in Structural Balance.  The American Chiropractor, March/April, 1982.

·         Chi YS, et al. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem Pharmacol. 2003 Oct 1:66(7): 127-8.

·         Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia.  Biochemical Pharmacology, 66 (2003) 1271-1278.

·         Giner-Larza EM, et al. Oleanolic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity. Eur J Pharmacol 428:137-43, 2001.

·         Glucosamine Sulfate Significantly Reduces Progression Of Knee Osteoarthritis Over 3 Years: A Large, Randomized, Placebo-Controlled, Double-Blind, Prospective Trial. J Y Reginster, R Deroisy, I Paul, R L Lee, Y Henrotin, G Giacovelli, J Dacre, L C Rovati, C Gosset. Source: American College of Rheumatology 1999 Annual Meeting, Boston, MA.

·         Hawk C. Manganese Deficiency and its Role in Structural Balance. The American Chiropractor, March/April, 1982.

·         Holick M, et al. Vitamin D: importance in the prevention of cancers, type I diabetes, heart disease and osteoporosis. Am J Clin Nutr 79:362-71, 2004.

·         Lemay M, Murray MA, et al. In vitro and ex vivo cyclooxygenase inhibition by a hops extract. Asia Pacific J Clin Nutr 13 (Suppl): S110, 2004.

·         Majeed, M. Boswellin: The Anti-inflammatory Phytonutrient. Piscataway, NJ: Nutri-science Publishers, Inc. 1996.

·         Manez, S., MC Recio, RM Giner and JL Rios.  Effect of selected triterpenoids on chronic dermal inflammation.  European Journal of Pharmacology, 1997, 334: 103-105.

·         Matheson AJ, et al. Glucosamine: a review of its use in the management of osteoarthritis. Drugs Aging: 20:1041-60, 2003.

·         Reginster JY, et al. Glucosamine sulfate significantly reduces progression of knee osteoarthritis over 3 years: A large, randomized, placebo-controlled, double-blind, prospective trial. American College of Rheumatology Annual Meeting, Boston MA, 1999.

·         Ricciardelli C, et al. Elevated stromal chondroitin sulfate gycosaminoglycan predicts progression in early-stage prostate cancer. Clin Cancer Res 3:983-92, 1997.

·         Shimamura, M. et al.  Inhibition of Angiogenesis by humulone, a bitter acid from beer hop.  Biochem Biophys Res Commun.  2001, Nov 23: 289 (1):220-4. 

·         Survey: Arthritis grips 25 percent of Americans  Crippling disease drains national health care system Friday, May 14, 2004 Posted: 9:43 AM EDT (1343 GMT)

·         Van Etten E, et al. 1,25-dihydroxycholecalciferol: endocrinology meets the immune system. Proc Nutrition Society 61:375-80, 2002.

·         Zerkak D. et al. The use of glucosamine therapy in osteoarthritis. Curr Rheumatol Rep 6:41-5, 2004.

What Makes Glucosatrin® Bone and Joint Formula Unique?

Few people consider the health and well-being of their bones and joints. Throughout a lifetime, the body’s joints sustain significant physical stress from everyday activities like walking, bending and lifting. Under normal conditions, the body is able to accomplish all of these activities with no problem because of the existence of cartilage. Cartilage is the smooth elastic tissue that covers the ends of bones, allowing them to glide across and cushion each other as the body moves. Bones and joints are intended to work synergistically to provide structure and flexibility.

The body sustains healthy joint maintenance by continually rebuilding and regenerating cartilage. This is what allows the bones and joints to uphold their shock-absorbing capabilities. However, as the body ages or incurs injuries, it is sometimes more difficult to sustain healthy cartilage regeneration. Glucosatrin® contains various key ingredients, such as vitamins, minerals and herbs that support healthy bones and joints. Glucosatrin promotes the retention and normal regeneration of cartilage and helps maintain joint comfort.*  

Frequently Asked Questions About Glucosatrin® Bone and Joint Formula:

Most bone and joint formulas contain chondroitin sulfate. Why doesn’t Glucosatrin® have this ingredient?
Chondroitin acts in a similar way to glucosamine; however, many studies performed on Chondroitin have had inconclusive results regarding its effectiveness. In one study, Chondroitin was linked to poor prostate health. Glucosamine is the safe, effective ingredient with no known side effects.

Can I take Glucosatrin® with other vitamin and mineral supplements?
Yes, you can take Glucosatrin with other products, including Isotonix OPC-3®, Isotonix® Multivitamin, Isotonix Calcium Plus, and Isotonix Advanced B-Complex.

If I am healthy and active, do I need Glucosatrin®?
Yes. Glucosatrin should be taken for its ability to help maintain proper joint function.*

Primary Benefits of Glucosatrin® Bone and Joint Formula*:

·         Helps regulate the immune response to stimuli

·         Promotes skeletal health

·         Helps maintain strong bones

·         Promotes normal movement and flexibility of joints

·         Promotes the retention and normal regeneration of cartilage

·         Helps maintain joint comfort

·         Promotes joint health and flexibility as you age

·         Supports normal, healthy 5-LOX and COX-2 levels

Key Ingredients Found In Glucosatrin® Bone and Joint Formula:

Glucosamine
Glucosamine is an aminopolysaccharide (a combination of the amino acid — glutamine and a sugar — glucose). Glucosamine is concentrated in joint cartilage where it is incorporated in longer chains known as glycosaminoglycans and finally into very large structures known as proteoglycans. Glucosamine is naturally produced by the body and is a key component of cartilage. Glucosamine supports healthy joint function and promotes the normal production of synovial fluid, which lubricates your joints and regenerates cartilage. 

There are numerous European studies showing a clear benefit of glucosamine supplements for promoting joint health.

Vitamin D3
Regular sunlight exposure is the primary means of attaining Vitamin D. Food sources of vitamin D include cod liver oil, fatty fish like salmon, egg yokes, liver and Vitamin D-fortified milk.

Vitamin D supports the absorption of calcium and phosphorus and promotes the production of several proteins involved in calcium absorption and storage.  Vitamin D works with calcium to promote hard, strong bones.  It promotes the normal transport of calcium out of the osteoblasts into the extra-cellular fluid and in the kidneys and promotes calcium and phosphate re-uptake by renal tubules.  Vitamin D also promotes the absorption of dietary calcium and phosphate uptake by the intestinal epithelium.

Vitamin C
Around 90 percent of vitamin C in the typical diet comes from fresh fruits and vegetables. Some of the best sources are peppers (sweet green and red peppers and hot red and green chili peppers), citrus fruits and juices, brussels sprouts, cauliflower, cabbage, kale, collards, mustard greens, broccoli, spinach and strawberries. Vitamin C is an antioxidant that promotes the normal growth and repair of tissue and supports adrenal gland function and gum health. It enhances immune function, supports the normal absorption of iron and supports cardiovascular health. It has been shown to operate as a signaling molecule to support the normal regulation of the synaptic efficiency of neurotransmitters dopamine and glutamic acid.

Manganese
The richest dietary sources of manganese include whole grains, nuts, leafy vegetables and teas. The efficiency of the absorption of manganese is low — around five percent. It may also help to alleviate some PMS symptoms and mood swings.

Low levels of manganese in the body can contribute to weakness. Manganese deficiencies are considered rare since it is relatively easy to obtain adequate amounts of manganese through the diet. Interestingly, some experts estimate that as many as 37 percent of Americans do not get the recommended daily amounts of manganese in their diet. This may be due to the fact that whole grains are a major source of dietary manganese, and many Americans consume refined grains more often than whole grains. Refined grains provide only half the amount of manganese as whole grains.

Additional benefits of manganese include: supporting calcium absorption, helping to maintain healthy blood pressure, promoting the normal formation of bones, supporting fat and carbohydrate metabolism and promoting the normal formation of sex hormones.

Boswellia Resin
The boswellia plant produces a resin that has been used in traditional Indian medicine as a support for joint health. The plant has a long history of safe and effective use for promoting joint comfort.  It supports normal mobility.

Boswellia Resin contains active boswellic acids which have been shown to support healthy cartilage and joint health.

Scutellaria Root
Scutellaria is also called Scullcap and is a member of the mint family. There are more than 100 related species of scutellaria throughout North America, Europe and China. In traditional Chinese medicine, scutellaria has been used for supporting healthy joints.

Three bioactive flavonoids — baicalin, baicalein and wogonin — have been extracted from scutellaria and are thought to contribute to the major activities of the plant. All three flavonoids have been shown to support healthy joints.

Oleanolic Acid
Oleanolic acid is found in numerous herbs used in Chinese and Ayurvedic medicine. Oleanolic Acid is isolated from the seeds of the plant Randia dumetornm (Rubiaceae). The compound promotes healthy joints.

Hops Extract
Hops (Humulus lupulus) have long been associated with beer and ale, but the beverage originally called ale in English was made from fermented malt only and contained no Hops. Although hops’ confirmed value lies in its use for sleep aid, this herb has also been used to stimulate the appetite, support the flow of digestive juices and promote bone health. 

Scientific Studies Which Support Glucosatrin^® Bone and Joint Formula:

·         Ammon HP. Salai Guggai - Boswellia serrata: from herbal medicine to a non-redox inhibitor of leukotriene biosynthesis. Eur J Med Res 1:369-70, 1996.

·         Anonymous. Boswellia seratta. Alternative Medicine Review 3:306-7, 1998.

·         Bowman BA and Russell RM. Present Knowledge in Nutrition, International Life Sciences Institute, 2001.

·         Cheryl Hawk, D.C.  Manganese Deficiency and its Role in Structural Balance.  The American Chiropractor, March/April, 1982.

·         Chi YS, et al. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem Pharmacol. 2003 Oct 1:66(7): 127-8.

·         Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia.  Biochemical Pharmacology, 66 (2003) 1271-1278.

·         Giner-Larza EM, et al. Oleanolic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity. Eur J Pharmacol 428:137-43, 2001.

·         Glucosamine Sulfate Significantly Reduces Progression Of Knee Osteoarthritis Over 3 Years: A Large, Randomized, Placebo-Controlled, Double-Blind, Prospective Trial. J Y Reginster, R Deroisy, I Paul, R L Lee, Y Henrotin, G Giacovelli, J Dacre, L C Rovati, C Gosset. Source: American College of Rheumatology 1999 Annual Meeting, Boston, MA.

·         Hawk C. Manganese Deficiency and its Role in Structural Balance. The American Chiropractor, March/April, 1982.

·         Holick M, et al. Vitamin D: importance in the prevention of cancers, type I diabetes, heart disease and osteoporosis. Am J Clin Nutr 79:362-71, 2004.

·         Lemay M, Murray MA, et al. In vitro and ex vivo cyclooxygenase inhibition by a hops extract. Asia Pacific J Clin Nutr 13 (Suppl): S110, 2004.

·         Majeed, M. Boswellin: The Anti-inflammatory Phytonutrient. Piscataway, NJ: Nutri-science Publishers, Inc. 1996.

·         Manez, S., MC Recio, RM Giner and JL Rios.  Effect of selected triterpenoids on chronic dermal inflammation.  European Journal of Pharmacology, 1997, 334: 103-105.

·         Matheson AJ, et al. Glucosamine: a review of its use in the management of osteoarthritis. Drugs Aging: 20:1041-60, 2003.

·         Reginster JY, et al. Glucosamine sulfate significantly reduces progression of knee osteoarthritis over 3 years: A large, randomized, placebo-controlled, double-blind, prospective trial. American College of Rheumatology Annual Meeting, Boston MA, 1999.

·         Ricciardelli C, et al. Elevated stromal chondroitin sulfate gycosaminoglycan predicts progression in early-stage prostate cancer. Clin Cancer Res 3:983-92, 1997.

·         Shimamura, M. et al.  Inhibition of Angiogenesis by humulone, a bitter acid from beer hop.  Biochem Biophys Res Commun.  2001, Nov 23: 289 (1):220-4. 

·         Survey: Arthritis grips 25 percent of Americans  Crippling disease drains national health care system Friday, May 14, 2004 Posted: 9:43 AM EDT (1343 GMT)

·         Van Etten E, et al. 1,25-dihydroxycholecalciferol: endocrinology meets the immune system. Proc Nutrition Society 61:375-80, 2002.

·         Zerkak D. et al. The use of glucosamine therapy in osteoarthritis. Curr Rheumatol Rep 6:41-5, 2004.

What Makes Glucosatrin® Bone and Joint Formula Unique?

Few people consider the health and well-being of their bones and joints. Throughout a lifetime, the body’s joints sustain significant physical stress from everyday activities like walking, bending and lifting. Under normal conditions, the body is able to accomplish all of these activities with no problem because of the existence of cartilage. Cartilage is the smooth elastic tissue that covers the ends of bones, allowing them to glide across and cushion each other as the body moves. Bones and joints are intended to work synergistically to provide structure and flexibility.

The body sustains healthy joint maintenance by continually rebuilding and regenerating cartilage. This is what allows the bones and joints to uphold their shock-absorbing capabilities. However, as the body ages or incurs injuries, it is sometimes more difficult to sustain healthy cartilage regeneration. Glucosatrin® contains various key ingredients, such as vitamins, minerals and herbs that support healthy bones and joints. Glucosatrin promotes the retention and normal regeneration of cartilage and helps maintain joint comfort.*  

Frequently Asked Questions About Glucosatrin® Bone and Joint Formula:

Most bone and joint formulas contain chondroitin sulfate. Why doesn’t Glucosatrin® have this ingredient?
Chondroitin acts in a similar way to glucosamine; however, many studies performed on Chondroitin have had inconclusive results regarding its effectiveness. In one study, Chondroitin was linked to poor prostate health. Glucosamine is the safe, effective ingredient with no known side effects.

Can I take Glucosatrin® with other vitamin and mineral supplements?
Yes, you can take Glucosatrin with other products, including Isotonix OPC-3®, Isotonix® Multivitamin, Isotonix Calcium Plus, and Isotonix Advanced B-Complex.

If I am healthy and active, do I need Glucosatrin®?
Yes. Glucosatrin should be taken for its ability to help maintain proper joint function.*